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Essential Hypertension

Calcium Mechanisms and Treatment

  • Book
  • © 1986

Overview

Editors:
  1. Kyuzo Aoki

    1. 2nd Department of Internal Medicine, Nagoya City University Medical School, Mizuho-ku, Nagoya, 467, Japan

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xi
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  2. Introduction: Spontaneously Hypertensive Rats

    1. Front Matter

      Pages 1-1
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    2. Discovery of the Spontaneously Hypertensive Rat

      • K. Aoki
      Pages 3-7

  3. Classification of Hypertension

    1. Front Matter

      Pages 9-9
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    2. Etiological Classification of Hypertension

      • K. Aoki
      Pages 11-24

  4. Calcium Mechanism in the Spontaneously Hypertensive Rat

    1. Front Matter

      Pages 25-25
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    2. Membrane Ca2+ Permeability and Calcium Antagonistic Effects in Resistance Vessels of Spontaneously Hypertensive Rats

      • C. Cauvin, C. van Breemen
      Pages 27-33

    3. Actions of Calcium Agonists and Antagonists on Femoral Arteries of Spontaneously Hypertensive Rats

      • M. Asano, K. Aoki, T. Matsuda
      Pages 35-49

    4. Altered Vascular Calcium Metabolism As a Possible Cause of Increased Blood Pressure in Essential Hypertension

      • M. J. Mulvany
      Pages 51-65

    5. Calcium-Membrane Interactions in Smooth Muscle in Relation to Hypertension

      • C. Y. Kwan
      Pages 67-80

    6. Actions of Calcium Antagonists on Smooth Muscle Cells of Vascular Tissues

      • Y. Ohya, K. Terada, S. Satoh, T. Fujiwara, T. Nagao, K. Komori et al.
      Pages 81-94

    7. Myogenic Activity of Vascular Tissues and the Effects of Calcium Agonists and Antagonists

      • K. Nakayama
      Pages 95-105

    8. Effects of Diltiazem on Myogenic Tone in Pressurized Brain Arteries from Spontaneously Hypertensive Rats

      • G. Osol, R. Osol, W. Halpern
      Pages 107-113

    9. Growth Factors and Vascular Smooth Muscle Cells in Spontaneously Hypertensive Rats

      • Y. Hirata, M. Tomita, T. Fujita
      Pages 115-124

    10. Calcium and Calcium Antagonists on Vascular Damage in Spontaneously and Dahl Hypertensive Rats

      • S. Kazda
      Pages 125-134

    11. Use of Isolated Membranes of Smooth Muscle to Study Calcium Channels

      • C. Y. Kwan, A. K. Grover, E. E. Daniel
      Pages 135-144

  5. Calcium Antagonists for Essential Hypertension

    1. Front Matter

      Pages 145-145
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    2. Therapeutic Role of Calcium Antagonists in Essential Hypertension

      • A. E. Doyle
      Pages 147-148

    3. Effects of Calcium Antagonists in Essential Hypertension with Special Reference to Renal Function

      • O. Lederballe Pedersen, L. R. Krusell, C. K. Christensen, L. T. Jespersen, K. Thomsen
      Pages 149-160

    4. Dihydropyridines As Antihypertensive Agents

      • C. Rosendorff, C. Goodman
      Pages 161-170
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Keywords

About this book

This volume contains papers presented at the First International Symposium on Mechanism and Treatment in Essential Hyperten­ sion, which was held on October 23 and 24, 1985 in Nagoya, Japan. The meeting was an official satellite symposium to the meeting of the Fifth International Symposium on Rats with Spon­ taneous Hypertension and Related Studies in Kyoto, October 20-22, 1985. The Nagoya symposium was made possible by offi­ cial grants from the city of Nagoya and Aichi Prefecture and the generous financial support of many companies. The aim of the symposium was to provide a forum for presen­ tation and discussion of recent advances in the area of essential hypertension, particularly with regard to calcium mechanisms in vasoconstriction and vasodilation in arterial vessels and the func­ tion of arterial smooth muscle. The role of calcium ions in the function of arterial smooth muscle has attracted a great deal of attention in the last two decades. The mode of action of calcium ions was revealed at the molecular level. The hypertension model of the spontaneously hypertensive rat has been widely utilized for research into the fundamental mechanisms of genetic hyperten­ sion, stroke, and cardiovascular disease as well as into therapeutic measures. New tools of calcium agonists and antagonists have become available to research into the mechanism, prevention, and treatment of essential hypertension at the molecular, subcellular, and cellular levels of arterial smooth muscle, at the organ level of arterial vessels, as well as at the total systemic level.

Editors and Affiliations

  • 2nd Department of Internal Medicine, Nagoya City University Medical School, Mizuho-ku, Nagoya, 467, Japan

    Kyuzo Aoki

Bibliographic Information

  • Book Title: Essential Hypertension

  • Book Subtitle: Calcium Mechanisms and Treatment

  • Editors: Kyuzo Aoki

  • DOI: https://doi.org/10.1007/978-4-431-68048-2

  • Publisher: Springer Tokyo

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Tokyo 1986

  • Softcover ISBN: 978-4-431-68050-5Published: 21 December 2011

  • eBook ISBN: 978-4-431-68048-2Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XII, 244

  • Topics: Cardiology, Psychotherapy, General Practice / Family Medicine

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