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The Genetics of Complex Thyroid Diseases

  • Conference proceedings
  • © 2002

Overview

Editors:
  1. Takashi Akamizu

    1. Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan

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  2. Masato Kasuga

    1. Department of Internal Medicine, Kobe University School of Medicine, Chuo-ku, Kobe, Japan

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  3. Terry F. Davies

    1. Division of Endocrinology and Metabolism, Mount Sinai School of Medicine, New York, USA

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  • Focusing on the autoimmune thyroid diseases and familial thyroid cancers

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Table of contents (14 papers)

  1. Front Matter

    Pages II-XI
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  2. Autoimmune Thyroid Diseases

    1. Front Matter

      Pages 1-1
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    2. Genetic Dissection of Familial Autoimmune Thyroid Diseases Using Whole Genome Screening

      • Yaron Tomer
      Pages 3-22

    3. Genome Screening for Graves’ Disease Susceptibility Loci in U.K. Families

      • B. Vaidya, H. Imrie, P. Kendall-Taylor, S. H. S. Pearce
      Pages 23-41

    4. The Involvement of the HLA Region in Genetic susceptibility to Graves’ disease

      • J. M. Heward
      Pages 42-54

    5. HLA and Autoimmune Thyroid Diseases

      • Ken Yamamoto, Takehiko Sasazuki
      Pages 55-63

    6. What Can We Learn from the Genetics of Diabetes?

      • Donald W. Bowden
      Pages 64-80

    7. The Genomic Biology of the Human Chromosome 2q33 Costimulatory Receptor Region

      • Vincent Ling, Gregory J. Fisk
      Pages 81-102

    8. CTLA-4 Gene in the Pathogenesis of Graves’ Disease

      • Tatsuo Yanagawa, Tsuyoshi Kouki, Leslie J. DeGroot
      Pages 103-107

    9. The evolving role of CTLA-4 in the genetic predisposition to AITD

      • Giuseppe Barbesino
      Pages 108-122

    10. Association of AITD with Microsatellite Markers for TSHR and CTLA-4 in Japanese Patients

      • Takashi Akamizu
      Pages 123-136

  3. Familial Thyroid Cancers

    1. Front Matter

      Pages 137-137
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    2. Familial Non Medullary Thyroid Cancer

      • Orlo H. Clark
      Pages 139-150

    3. Cowden Disease and the PTEN/MMAC1 Gene

      • Bryan McIver, Norman L. Eberhardt
      Pages 151-175

    4. Molecular Mechanisms of RET Activation in Human Neoplasia

      • Massimo Santoro, Francesca Carlomagno, Rosa Marina Melillo, Giancarlo Vecchio, Alfredo Fusco
      Pages 176-183

    5. Lessons From Chernobyl; Need for Molecular Epidemiology of Childhood Thyroid Cancer

      • Shunichi Yamashita, Hiroyuki Namba, Noboru Takamura, Kiyoto Ashizawa, Yoshisada Shibata
      Pages 184-197

    6. Genetic Events in Radiation-Induced Thyroid Cancer

      • Yuri E. Nikiforov
      Pages 198-219

  4. Back Matter

    Pages 220-222
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Keywords

About this book

The rapid developments in molecular genetics have clarified many of the muta­ tions in monogenic thyroid diseases over the last two decades; now the target of molecular thyroid genetics has become the oligogenic thyroid diseases. These include the autoimmune thyroid diseases and familial thyroid cancers, both of which are much commoner than the monogenic diseases. However, the method­ ological approach to the genetics of these more complex diseases is still far from being well established. Although the discovery of susceptibility genes has been partially accomplished in complex diseases such as asthma, Crohn's dis­ ease, and types I and II diabetes mellitus, the elucidation of susceptibility genes in complex diseases remains a major challenge. This volume contains papers presented at the International Symposium on the Genetics of Complex Thyroid Diseases. This meeting was held in association with the International Thyroid Congress in Kyoto in October 2000 and sup­ ported in part by the Japan Intractable Diseases Research Foundation and Knoll Pharmaceuticals Inc. The symposium was the first international symposium con­ cerning the genetics of complex thyroid diseases and was restricted to the study of the autoimmune thyroid diseases and familial thyroid cancer. Twenty distin­ guished researchers from the United States, the United Kingdom, France, Ger­ many, Italy, and Japan were invited. Each presentation precipitated intense dis­ cussion and there was much consensus during the meeting. Nevertheless, this volume will leave the reader with a clear understanding of how little we still know.

Editors and Affiliations

  • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan

    Takashi Akamizu

  • Department of Internal Medicine, Kobe University School of Medicine, Chuo-ku, Kobe, Japan

    Masato Kasuga

  • Division of Endocrinology and Metabolism, Mount Sinai School of Medicine, New York, USA

    Terry F. Davies

Bibliographic Information

  • Book Title: The Genetics of Complex Thyroid Diseases

  • Editors: Takashi Akamizu, Masato Kasuga, Terry F. Davies

  • DOI: https://doi.org/10.1007/978-4-431-67885-4

  • Publisher: Springer Tokyo

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Japan 2002

  • Hardcover ISBN: 978-4-431-70325-9Published: 01 January 2002

  • Softcover ISBN: 978-4-431-68002-4Published: 20 November 2013

  • eBook ISBN: 978-4-431-67885-4Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XI, 222

  • Topics: Endocrinology

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