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Slow Synaptic Responses and Modulation

  • Conference proceedings
  • © 2000

Overview

Editors:
  1. Kenji Kuba

    1. Department of Physiology, Nagoya University School of Medicine, Showa-ku, Nagoya, Aichi, Japan

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  2. Haruhiro Higashida

    1. Department of Biophysical Genetics, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan

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  3. David A. Brown

    1. Department of Pharmacology, University College London, London, England, UK

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  4. Tohru Yoshioka

    1. Department of Molecular Neurobiology, School of Human Science, Waseda University, Tokorozawa, Saitama, Japan

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  • To offer the basic concept and current understanding of slow synaptic responses, modulation and plasticity in nervous systems

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Table of contents (63 papers)

  1. Front Matter

    Pages II-XVI
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  2. The Dawn and Foundation of Slow Synaptic Potentials and Modulation

    1. The Dawn and Foundation of Slow Synaptic Potentials and Modulation

      • K. Koketsu
      Pages 1-14

  3. M-Currents and Modulation

    1. M-Current: From Discovery to Single Channel Currents

      • D. A. Brown
      Pages 15-26

    2. Properties of Muscarine-Sensitive Potassium Currents in Vertebrate Nerve Cells

      • T. Tokimasa, T. Nishimura
      Pages 27-34

    3. Slow Synaptic Responses in Neuronal Tumor Cells: Dual Regulation of ADP-Ribosyl Cyclase and Inhibition of M-Current by Muscarinic Receptor Stimulation

      • H. Higashida, S. Yokoyama, M. Hashii, M. Taketo
      Pages 35-41

    4. Acetylcholine-Like Effect of Sulfhydryl-Modifying Reagents on M-Current in Rodent NG108-15 Cells

      • A. B. Egorova, N. Hoshi, H. Higashida
      Pages 42-45

    5. Inhibition of M-Type K+ currents by Cognition Enhancers in NG108-15 Cells and Rat Cerebral Neurons in Culture

      • M. Noda, H. Higashida, N. Akaike
      Pages 46-48

    6. Muscarinic Inhibition of M-current in Bullfrog Sympathetic Neurones is Independent of Intracellular Ca2+ Release

      • T. Akita, K. Kuba
      Pages 49-51

  4. K+ Currents and Modulation

    1. Introductory Review: K Currents and Modulation

      • D. A. Brown
      Pages 52-58

    2. The Role of Mg2+ in the Modulation of IRK3 by M1 Acetylcholine Receptor

      • H. Chuang, L. Y. Jan, Y. N. Jan
      Pages 59-66

    3. Temporal Profile of Muscarinic Modulation of the Slow Ca2+-Dependent K+ Current (IsAHP) in Rat Hippocampal Neurons

      • L. Zhang, A. A. Velumian, P. S. Pennefather, P. L. Carlen
      Pages 67-77

    4. Modulation of K+ Channels in Hippocampal Neurons: Transmitters Acting via Cyclic AMP Enhance the Excitability of Hippocampal Neurons Through Kinase-Dependent and -Independent Modulation of AHP- and h-Channels

      • J. F. Storm, P. Pedarzani, T. Haug, T. Winther
      Pages 78-92

    5. Three Types of Cerebellar Voltage-Gated K+ Currents Expressed in Xenopus Oocytes

      • N. Hoshi, H. Takahashi, S. Yokoyama, H. Higashida
      Pages 93-96

    6. Facilitatory Effect of Calmodulin-Dependent Protein Kinase on the K+-Current Responses to Dopamine, Acetylcholine, and Phe-Met-Arg-Phe-NH2 in the Ganglion Cells of Aplysia

      • S. Kawasaki, S. Kimura, R. Fujita, K. Takashima, K. Sasaki, M. Sato
      Pages 97-100

  5. Ca2+ Currents and Modulation

    1. Introductory Review: Calcium Channels and Modulation

      • L. Gandía, A. Albillos, C. Montiel, A. G. García
      Pages 101-120

    2. Neuronal T-Type Calcium Channels: Pharmacology and Investigation of Subunit Composition

      • A. Meir, C. N. Wyatt, G. J. Stephens, A. C. Dolphin
      Pages 121-129

    3. Exocytosis Calcium Channels: Autocrine/Paracrine Modulation

      • A. G. García, J. M. Hernández-Guijo, I. Mayorgas, L. Gandía
      Pages 130-146

    4. Synaptic Modulation Mediated by G-Protein-Coupled Presynaptic Receptors

      • T. Takahashi
      Pages 147-153

    5. Presynaptic Glutamate Receptors in the Hippocampus

      • H. Kamiya
      Pages 154-157

    6. The α1-Subunit of the L-Type Ca2+ Channel Is Converted to a Long Open and Noninactivating State by Large Depolarization

      • S. Nakayama, M. Kuzuya, M. Miyoshi, K. Kuba, Y. Okamura
      Pages 158-160
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Keywords

About this book

Information flow as nerve impulses in neuronal circuits is regulated at synapses. The synapse is therefore a key element for information processing in the brain. Much attention has been given to fast synaptic transmission, which predominantly regulates impulse-to-impulse transmission. Slow synaptic transmission and modu­ lation, however, sometimes have been neglected in considering and attempting to understand brain function. Slow synaptic potentials and modulation occur with a considerable delay in response to the accumulation of synaptic and modulatory inputs. In these contexts, they are plastic in nature and play important roles in information processing in the brain. A symposium titled "Slow Synaptic Responses and Modulation" was held as the satellite symposium to the 75th Annual Meeting of the Physiological Society of Japan on March 30-31, 1998, in Kanazawa. The theme was selected not only for the reason mentioned above, but also because of the considerable involvement of many Japanese scholars in establishing the basic issues. Following the dawn of synaptic physiological research, as Sir John Eccles, Sir Bernard Katz, and Professor Stephen Kuffler carried out pioneer work, Professor Kyozou Koketsu and Professor Benjamin Libet, the students of Sir John Eccles, and their colleagues established the concept of slow synaptic responses and modulation by studying vertebrate sympathetic ganglia. Since then, the concept has been ex­ panded with detailed investigations of both peripheral and central synapses at the levels of single ion channels, intracellular Ca"+ dynamics, intracellular transduc­ tion mechanisms, and genes.

Editors and Affiliations

  • Department of Physiology, Nagoya University School of Medicine, Showa-ku, Nagoya, Aichi, Japan

    Kenji Kuba

  • Department of Biophysical Genetics, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan

    Haruhiro Higashida

  • Department of Pharmacology, University College London, London, England, UK

    David A. Brown

  • Department of Molecular Neurobiology, School of Human Science, Waseda University, Tokorozawa, Saitama, Japan

    Tohru Yoshioka

Bibliographic Information

  • Book Title: Slow Synaptic Responses and Modulation

  • Editors: Kenji Kuba, Haruhiro Higashida, David A. Brown, Tohru Yoshioka

  • DOI: https://doi.org/10.1007/978-4-431-66973-9

  • Publisher: Springer Tokyo

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Japan 2000

  • Hardcover ISBN: 978-4-431-70249-8Published: 01 November 1999

  • Softcover ISBN: 978-4-431-66975-3Published: 20 April 2014

  • eBook ISBN: 978-4-431-66973-9Published: 17 April 2013

  • Edition Number: 1

  • Number of Pages: XVI, 455

  • Topics: Neurosciences, Human Physiology, Pharmacology/Toxicology

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