Molecular Pathology of Gastroenterological Cancer

1. Front Matter

   Pages II-VIII

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2. Experimental Stomach Carcinogenesis

   • Hiroko Ohgaki, Takashi Sugimura

   Pages 1-14

3. Multistep Carcinogenesis of Esophageal Carcinoma

   • Yusuke Nakamura, Takashi Tokino, Minoru Isomura, Johji Inazawa, Takahisa Aoki, Takahiro Mori et al.

   Pages 15-21

4. Oxidative Damage During the Gastric Precancerous Process

   • Pelayo Correa, Mark Miller, Elizabeth E. Mannick

   Pages 23-29

5. Multiple Genetic Alterations and Abnormal Growth Factor Network in Human Esophageal Carcinomas

   • Kazuhiro Yoshida, Wataru Yasui, Yoshihiro Kagawa, Eiichi Tahara

   Pages 31-41

6. Genetic Alterations in the Precursors of Gastric Cancer

   • Atsushi Ochiai, Setsuo Hirohashi

   Pages 43-53

7. Molecular Bases of Human Stomach Carcinogenesis

   • Hiroshi Yokozaki, Hiroki Kuniyasu, Shuho Semba, Wataru Yasui, Eiichi Tahara

   Pages 55-70

8. Galectins in Gastric and Colorectal Cancers: Implications for Tumor Progression and Metastasis

   • Reuben Lotan, Eiichi Tahara

   Pages 71-80

9. Stomach Cancer and Apoptosis: A Review

   • Hisao Ito, Masato Ishida, Satoshi Ohfuji, Mitsuhiko Osaki, Hisae Hayashi, Shigeru Tatebe

   Pages 81-92

10. Pathogenesis of Serrated Adenoma of the Colorectum: Implication for Malignant Progression

    • Fumio Shimamoto, Shinji Tanaka, Eiichi Tahara

    Pages 93-106

11. Carcinoma Cells at Deeply Infiltrated Sites: Role in Development of Metastases in Patients with Advanced Colorectal Adenocarcinomas

    • Kiyomi Taniyama, Naomi Sasaki, Hiroshi Maruyama, Hayao Nakai, Hirofumi Nakatsuka, Kazushige Toyama et al.

    Pages 107-127

12. Glycoprotein Histochemistry and the Histogenesis of Colorectal Cancer

    • Jeremy R. Jass

    Pages 129-146

13. Critical Determinants of Human Colon Cancer Metastasis

    • Isaiah J. Fidler

    Pages 147-169

14. Abnormal CD44 Gene Expression in Neoplasia: Biological and Clinical Implications

    • David Tarin

    Pages 171-185

15. Molecular Diagnosis of Gastrointestinal Cancer

    • Wataru Yasui, Hiroshi Yokozaki, Eiichi Tahara

    Pages 187-207

16. Interactive Effects of p53 Tumor Suppressor Gene and Hepatitis B Virus in Hepatocellular Carcinogenesis

    • Libin Jia, Xin Wei Wang, Zongtang Sun, Curtis C. Harris

    Pages 209-218

17. Molecular Genetics of Hepatocellular Carcinoma

    • Christopher J. Bakkenist, James O’D. McGee

    Pages 219-243

18. Telomeres and Telomerase in Gastrointestinal Cancers

    • Hidetoshi Tahara, Eiji Tahara, Eiichi Tahara, Toshinori Ide

    Pages 245-259

19. Back Matter

    Pages 261-267

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Twenty years have passed since I became a professor in the First Department of Pathology, Hiroshima University School of Medicine. It is my great pleas­ ure that Molecular Pathology o[ Gastroenterological Cancer-Application to Clinical Practice has been published by Springer-Verlag Tokyo to commemo­ rate the 20th anniversary of my professorship. Seeing the academic achievements of our department during these 20 years, I am confident that we could establish a department of oncology to research the pathogenesis of human cancer through systemic application of a variety of molecular techniques. We have demonstrated that the develop­ me nt and progression of esophageal, gastric, and colon cancer require mul­ tiple alterations affecting DNA mismatch repair genes, oncogenes, and tumorsuppressor genes, and that common and uncommon genetic changes exist for esophageal, gastric, and colorectal carcinomas. In addition to these genetic changes, the majority of gastrointestinal cancers express telomerase activity, with overexpression of telomerase RNA, indicating a powerful addi­ tional tool for early detection of gastrointestinal cancer. By transferring these basic observations to the clinic, we now are able to make accurate cancer diagnoses, thus determing the grade of malignancy and patient prognosis. We also can identify patients at high risk for developing cancer and create new therapeutic approaches. In fact, we have routinely implemented a new molecular diagnosis strategy at the Hiroshima City Medi­ cal Association Clinical Laboratory since August 1993.

• apoptosis
• cancer
• carcinogenesis
• carcinoma
• colon
• colorectal cancer
• gastric cancer
• gastroenterology
• gastrointestinal cancer
• genetics
• metastasis
• molecular genetics
• molecular pathology
• pathology
• stomach

• Faculty of Medicine, First Department of Pathology, Hiroshima University School of Medicine, Minami-ku, Hiroshima 734, Japan

  Eiichi Tahara

Policies and ethics