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Muse Cells

Endogenous Reparative Pluripotent Stem Cells

  • Book
  • © 2018

Overview

Editors:
  1. Mari Dezawa

    1. Tohoku University Graduate School of Medicine, Sendai, Japan

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  • Presents up-to-date knowledge on Muse cells, newly recognized pluripotent stem cells that will be vital for next-generation medical care
  • Covers all aspects from molecular and cellular properties to differentiation ability, tissue repair properties, and the diverse potential clinical applications of Muse cells
  • Provides a precise protocol for collection of Muse cells

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1103)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xii
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  2. The Muse Cell Discovery, Thanks to Wine and Science

    • Mari Dezawa
    Pages 1-11

  3. Basic Characteristics of Muse Cells

    • Shohei Wakao, Yoshihiro Kushida, Mari Dezawa
    Pages 13-41

  4. Muse Cells Are Endogenous Reparative Stem Cells

    • Yoshihiro Kushida, Shohei Wakao, Mari Dezawa
    Pages 43-68

  5. Protocols for Isolation and Evaluation of Muse Cells

    • Kazuki Tatsumi, Yoshihiro Kushida, Shohei Wakao, Yasumasa Kuroda, Mari Dezawa
    Pages 69-101

  6. Stem Cells and DNA Repair Capacity: Muse Stem Cells Are Among the Best Performers

    • Tiziana Squillaro, Nicola Alessio, Giovanni Di Bernardo, Servet Özcan, Gianfranco Peluso, Umberto Galderisi
    Pages 103-113

  7. Immunomodulatory Properties and Potential Therapeutic Benefits of Muse Cells Administration in Diabetes

    • Marcelo Javier Perone, María Laura Gimeno, Florencia Fuertes
    Pages 115-129

  8. The Role of the Mitochondria in the Evolution of Stem Cells, Including MUSE Stem Cells and Their Biology

    • James E. Trosko
    Pages 131-152

  9. Acute Myocardial Infarction, Cardioprotection, and Muse Cells

    • Shinya Minatoguchi, Atsushi Mikami, Toshiki Tanaka, Shingo Minatoguchi, Yoshihisa Yamada
    Pages 153-166

  10. Application of Muse Cell Therapy to Stroke

    • Kuniyasu Niizuma, Cesar V. Borlongan, Teiji Tominaga
    Pages 167-186

  11. Muse Cell: A New Paradigm for Cell Therapy and Regenerative Homeostasis in Ischemic Stroke

    • Satoshi Kuroda, Masaki Koh, Emiko Hori, Yumiko Hayakawa, Takuya Akai
    Pages 187-198

  12. Application of Muse Cell Therapy for Kidney Diseases

    • Nao Uchida, Naonori Kumagai, Yoshiaki Kondo
    Pages 199-218

  13. Liver Regeneration Supported by Muse Cells

    • Satoshi S. Nishizuka, Yuji Suzuki, Hirokatsu Katagiri, Yasuhiro Takikawa
    Pages 219-241

  14. Current Cell-Based Therapies in the Chronic Liver Diseases

    • Taketo Nishina, Kyoko Tomita Hoshikawa, Yoshiyuki Ueno
    Pages 243-253

  15. Artificial Pigmented Human Skin Created by Muse Cells

    • Takeshi Yamauchi, Kenshi Yamasaki, Kenichiro Tsuchiyama, Setsuya Aiba
    Pages 255-271

  16. Muse Cells and Aortic Aneurysm

    • Katsuhiro Hosoyama, Yoshikatsu Saiki
    Pages 273-291

  17. Muse Cells and Ischemia-Reperfusion Lung Injury

    • Hiroshi Yabuki, Tatsuaki Watanabe, Hisashi Oishi, Masato Katahira, Masahiko Kanehira, Yoshinori Okada
    Pages 293-303

  18. Clinical Trials of Muse Cells

    • Mari Dezawa
    Pages 305-307

  19. Future of Muse Cells

    • Wise Young
    Pages 309-315

  20. Correction to: Basic Characteristics of Muse Cells

    • Shohei Wakao, Yoshihiro Kushida, Mari Dezawa
    Pages C1-C1
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Keywords

About this book

This book provides the first comprehensive account of multilineage-differentiating stress-enduring (Muse) cells, a pluripotent and non-tumorigenic subpopulation of mesenchymal stem cells (MSCs) that have the ability to detect damage signals, migrate to damaged sites, and spontaneously differentiate into cells compatible with the affected tissue, thereby enabling repair of all tissue types. The coverage encompasses everything from the basic properties of Muse cells to their tissue repair effects and potential clinical applications—for example, in acute myocardial infarction, stroke, skin injuries and ulcers, renal failure, and liver disease. An important technical chapter provides a practical and precise protocol for the isolation of Muse cells, which will enable readers to use Muse cells in their own research. In offering fascinating insights into the strategic organization of the body’s reparative function and explaining how full utilization of Muse cells may significantly enhancethe effectiveness of MSC treatment, the book will be of high value for Ph.D. students, postdocs, basic researchers, clinical doctors, and industrial developers.

Editors and Affiliations

  • Tohoku University Graduate School of Medicine, Sendai, Japan

    Mari Dezawa

About the editor

Mari Dezawa, M.D., Ph.D., is professor and chairperson at the Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine (Japan). She has contributed to regenerative medicine by discovering non-tumorigenic reparative pluripotent stem cells, multilineage-differentiating stress-enduring (Muse) cells that naturally reside in the living body. Dr. Dezawa graduated from Chiba University School of Medicine in 1989 and gained her Ph.D. from the same university in 1995. In 2000 she joined Yokohama City University, where she started mesenchymal stem cell (MSC) research. After moving to Kyoto University Graduate School of Medicine as associate professor in 2003, she discovered methods to induce neurons and skeletal muscle cells from human MSCs by combining gene introduction and cytokine stimulation. In 2008, she became professor and chair of the Department of Stem Cell Biology and Histology at Tohoku University Graduate School of Medicine. She subsequently has published a number of articles in leading journals on Muse cells and their reparative functions in animal disease models. Dr. Dezawa is the author of more than 120 original articles in international journals and serves as an editorial board member of several international journals. She is a fellow of the National Academy of Inventors, USA.

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