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Photoaffinity Labeling for Structural Probing Within Protein

  • Book
  • © 2017

Overview

Editors:
  1. Yasumaru Hatanaka

    1. University of Toyama, Toyama, Japan

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  2. Makoto Hashimoto

    1. Graduate School of Agriculture, Hokkaido University, Sapporo, Japan

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    You can also search for this editor in PubMed   Google Scholar

  • Provides a reliable strategy to probe molecular targets during the early stages of drug discovery and development

  • Describes the potential of updated photoaffinity labeling among chemical methods for the structural elucidation of proteins

  • Clarifies the chemical biology for the design and development of high-performance photoaffinity probes

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. Multifunctional Photoprobes for Identification of Ligand Sites Within Biomolecules

    • Makoto Hashimoto
    Pages 1-11

  3. Tag-Creation Approaches for Highly Efficient Profiling of Interacting Proteins and Domains

    • Takenori Tomohiro
    Pages 13-43

  4. Recent Developments in Designing Compact Biological Photoprobes

    • Amberlyn M. Wands, Jennifer J. Kohler
    Pages 45-78

  5. Utilities of Anti-ligand Antibody and Mass Spectrum to Elucidate Photolabeled Sites

    • Kohichi Kawahara, Katsuyoshi Masuda, Masaji Ishiguro, Hitoshi Nakayama
    Pages 79-92

  6. Combination of Photoaffinity Label and Site-Directed Antibody for Target Proteins

    • Akihiko Kuniyasu, Hitoshi Nakayama
    Pages 93-110

  7. Synthesis of Diazirinyl Photophore and Optically Pure Diazirinylphenylalanines for Photoaffinity Labeling

    • Yuta Murai, Lei Wang, Makoto Hashimoto
    Pages 111-128

  8. Photoreactive Biomacromolecules: Installation of Photoreactive Units and Applications for Analyzing Biological Interfaces

    • Yutaka Sadakane, Isao Ohtsuka, Yasumaru Hatanaka
    Pages 129-157

  9. Covalently Capturing Protein Interactions in Living Cells by Site-Specific Incorporation of Photo-Cross-Linkable Amino Acids

    • Nobumasa Hino, Kensaku Sakamoto
    Pages 159-181

  10. Use of Hexose Photolabels to Reveal the Structure and Function of Glucose Transporters

    • Geoffrey D. Holman
    Pages 183-196

  11. Function of Peroxisome in Mammal and Analysis of the Fatty Acid Oxidation System by Photoaffinity Labeling

    • Tsuneo Imanaka, Kosuke Kawaguchi, Masashi Morita
    Pages 197-223

  12. Photoaffinity Labeling Methods to Explore Internalization Mechanisms of Arginine-Rich Cell-Penetrating Peptides

    • Gen Tanaka, Yoshimasa Kawaguchi, Keiko Kuwata, Toshihide Takeuchi, Ikuhiko Nakase, Shiroh Futaki
    Pages 225-240

  13. Photoaffinity Labeling in Drug Discovery Research

    • Hideyuki Muranaka, Takaki Momose, Chiaki Handa, Tomonaga Ozawa
    Pages 241-265
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Keywords

About this book

This book covers the most up-to-date photoaffinity labeling method to tackle the key loop module involved in the binding process of a bioactive small molecule to its host protein. The book introduces rational points for preparing powerful photoaffinity probes, keys for the efficient analysis of labeled products, and recent successful applications for protein probing. Regarding drug design, the unique topics of the book are the special consideration of the crosslinking potential of recent probes and their application of important receptor proteins . This book presents emerging technologies of photoaffinity labeling to readers who are working in the fields of proteomics, molecular recognition, and drug discovery and development.

Editors and Affiliations

  • University of Toyama, Toyama, Japan

    Yasumaru Hatanaka

  • Graduate School of Agriculture, Hokkaido University, Sapporo, Japan

    Makoto Hashimoto

About the editors

​Yasumaru Hatanaka, PhD
Executive Vice President, University of ToyamaToyama, Japan


Makoto Hashimoto, PhD
Graduate School of Agriculture, Hokkaido University
Sapporo, Japan

Bibliographic Information

  • Book Title: Photoaffinity Labeling for Structural Probing Within Protein

  • Editors: Yasumaru Hatanaka, Makoto Hashimoto

  • DOI: https://doi.org/10.1007/978-4-431-56569-7

  • Publisher: Springer Tokyo

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Japan KK 2017

  • Hardcover ISBN: 978-4-431-56568-0Published: 09 October 2017

  • Softcover ISBN: 978-4-431-56823-0Published: 22 August 2018

  • eBook ISBN: 978-4-431-56569-7Published: 25 September 2017

  • Edition Number: 1

  • Number of Pages: VIII, 265

  • Number of Illustrations: 100 b/w illustrations, 48 illustrations in colour

  • Topics: Pharmaceutical Sciences/Technology, Biochemical Engineering

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