Skip to main content
  • Book
  • © 2018

Bone Adaptation

In Silico Approach

  • Is the first book that describes theoretical approaches to bone functional adaptation
  • Provides multiscale modeling of trabecular bone remodelling and quantitative prediction of 3D hierarchical bone structure
  • Helps readers to understand bone morphology and metabolism based on mathematical approaches

Part of the book series: Frontiers of Biomechanics (FB, volume 2)

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

This is a preview of subscription content, log in via an institution to check for access.

Table of contents (14 chapters)

  1. Front Matter

    Pages i-xiv
  2. Overview: In Silico Approaches to Understand Bone Adaptation

    • Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi
    Pages 1-11
  3. Microscopic Fluid Flow Analysis in an Osteocyte Canaliculus

    • Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi
    Pages 13-24
  4. Macroscopic Fluid Flow Analysis in a Poroelastic Trabecula

    • Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi
    Pages 25-44
  5. Estimation of Bone Permeability for Poroelastic Analysis

    • Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi
    Pages 45-63
  6. Modeling Trabecular Bone Adaptation Induced by Flow Stimuli to Osteocytes

    • Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi
    Pages 65-81
  7. Effects of Local Bending Load on Trabecular Bone Adaptation

    • Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi
    Pages 83-90
  8. Cancellous Bone Adaptation Predicted by Remodeling Simulations

    • Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi
    Pages 91-101
  9. Trabecular Surface Remodeling Toward Uniform Local Stress State

    • Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi
    Pages 103-119
  10. Spatial and Temporal Regulation of Cancellous Bone Structure by Trabecular Surface Remodeling

    • Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi
    Pages 121-129
  11. Comparison of Mechanical Quantities as Bone Remodeling Stimuli

    • Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi
    Pages 131-144
  12. Functional Adaptation of Cancellous Bone in Human Proximal Femur

    • Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi
    Pages 163-175
  13. 3D Trabecular Remodeling in Human Proximal Femur: Approach to Understanding Wolff’s Law

    • Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi
    Pages 177-185
  14. Trabecular Structural Changes in a Vertebral Body with a Fixation Screw

    • Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi
    Pages 187-203
  15. Back Matter

    Pages 205-209

About this book

This book focuses on the systems biomechanics of bone remodeling that provide a multiscale platform for bone adaptation, spanning the cellular, tissue, and organ levels. The mathematical model explained in each section provides concrete examples of in silico approaches for bone adaptation. It will be immensely useful for readers interested in bone morphology and metabolism and will serve as an effective bridge connecting mechanics, cellular and molecular biology, and medical sciences. These in silico approaches towards exploring the mechanisms by which the functioning of dynamic living systems is established and maintained have potential for facilitating the efforts of graduate students and young researchers pioneering new frontiers of biomechanics.

Authors and Affiliations

  • Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan

    Yoshitaka Kameo, Taiji Adachi

  • Graduate School of Engineering, Chiba University, Chiba, Japan

    Ken-ichi Tsubota

Bibliographic Information

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access