Overview
- Editors:
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Takeshi Watanabe
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Kitano Hospital, Kita-ku, Japan
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Yousuke Takahama
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Division of Experimental Immunology, University of Tokushima, Tokushima, Japan
principles of synthetic immunology versus classic studies in immunology
Covers development and
regeneration of T-cells
Examines tissue
reconstitution by 3D bio-printer
Includes supplementary material: sn.pub/extras
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Table of contents (9 chapters)
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- Daniel J. Wesche, Hiromitsu Nakauchi
Pages 1-30
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- Hiroshi Kawamoto, Tomokatsu Ikawa, Takuya Maeda, Kyoko Masuda
Pages 31-56
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- Marco Barsanti, Michael Hun, Richard Boyd, Ann Chidgey
Pages 57-94
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- Mahmood Mohtashami, Shreya Shukla, Peter Zandstra, Juan Carlos Zúñiga-Pflücker
Pages 95-120
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- Elisa Lenti, Andrea Brendolan
Pages 121-133
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- Sergio A. Lira, Glaucia C. Furtado
Pages 135-150
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- Yuka Kobayashi, Koichi Kato, Makoto Nakamura, Takeshi Watanabe
Pages 151-169
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- Makoto Nakamura, Kenichi Arai, Takahito Mimura, Jungo Tagawa, Hirotoshi Yoshida, Koichi Kato et al.
Pages 181-200
About this book
This book reviews the emerging studies of synthetic immunology, including the development and regeneration of immune cells, immune organ development and artificial regeneration, and the synthetic approach towards understanding human immune system.
Immunology has developed rapidly over the last 50 years through the incorporation of new methods and concepts in cell and molecular biology, genetics, genomics and proteomics. This progress is the result of works by many excellent researchers all over the world. Currently, immunological research has accumulated detailed knowledge on basic mechanisms of immunity and is in the process to change medical practices. Yet, due to the enormous complexity of the immune system, many aspects on the regulation and function of this system remain unknown. Synthetic biology uses gain-of-function rather than loss-of-function approaches. The goals of synthetic biology can be described in a simple phrase “rebuild, alter, and understand,” namely, to rebuild minimal functional systems using well-defined parts from nature and then to perturb the system to understand its working principles. Given the richness of accumulated knowledge in molecular and cellular mechanisms of the immune system, we now begin adapting the concepts of synthetic biology to immunology. An immune response is a spatiotemporal phenomenon occurring at a given time and at a specialized place in the body. One goal of synthetic immunology is to reconstruct artificial microenvironments for better understanding of an immune response. We hope this yet-to-be-experimental approach of synthetic immunology and the compilation of this book will aid our further understanding of the immune system and future devising the tools to manipulate the immune system for therapy and prevention of the diseases.
Editors and Affiliations
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Kitano Hospital, Kita-ku, Japan
Takeshi Watanabe
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Division of Experimental Immunology, University of Tokushima, Tokushima, Japan
Yousuke Takahama
About the editors
Takeshi Watanabe, MD, PhD., Emeritus Professor of Kyushu University, and Specially Appointed Research Instructor, The Tazuke-Kofukai Medical Research Institute/Kitano Hospital.
Yousuke Takahama, PhD., Professor of Experimental Immunology, Institute for Genome Research, University of Tokushima.
