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Glycosignals in Cancer: Mechanisms of Malignant Phenotypes

  • Book
  • © 2016

Overview

Editors:
  1. Koichi Furukawa

    1. Biomedical Sciences, Chubu University, Kasugai, Japan

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    You can also search for this editor in PubMed   Google Scholar

  2. Minoru Fukuda

    1. Glycobiology Unit, Sanford-Burnham Med Res Inst, La Jolla, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Shows how sugar chains are critically involved in malignant phenotypes of cancers
  • Presents a variety of modes by which sugar chains modulate cell signals determining cell fates
  • Explains how up-to-date results of life technology and information are being applied in glycobiology research of cancers
  • Inspires the application of knowledge about signals generated via glycosylation for diagnosis and therapy of cancers

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-viii
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  2. Changes of Glycosylation Machineries in Cancer Cells

    1. Front Matter

      Pages 1-1
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    2. Roles of Fucosyltransferases in Cancer Phenotypes

      • Eiji Miyoshi, Naofumi Uozumi, Tomoaki Sobajima, Shinji Takamatsu, Yoshihiro Kamada
      Pages 3-16

    3. Glycosyltransferases and Gastric Cancer

      • Celso A. Reis, Ana Magalhães
      Pages 17-32

  3. Regulation of Cancer Phenotypes by Carbohydrates

    1. Front Matter

      Pages 33-33
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    2. Differential Roles of Mammalian Sialidases in Cancers

      • Taeko Miyagi
      Pages 35-53

  4. Altered Cell Signaling in Cancer Cells

    1. Front Matter

      Pages 55-55
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    2. Regulatory Mechanisms for Malignant Properties of Cancer Cells with Disialyl and Monosialyl Gangliosides

      • Koichi Furukawa, Yuki Ohkawa, Yasuyuki Matsumoto, Yuhsuke Ohmi, Noboru Hashimoto, Keiko Furukawa
      Pages 57-76

    3. Regulation of Growth Factor Receptors by Glycosphingolipids

      • Sen-itiroh Hakomori, Kazuko Handa
      Pages 77-93

    4. Nutrient Regulation of Cancer Cells by O-GlcNAcylation

      • Xin Liu, Gerald W. Hart
      Pages 95-108

  5. Regulation of Immune Systems and Cancers by Carbohydrates

    1. Front Matter

      Pages 109-109
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    2. Function of Unique O-Glycan Structures in Protecting Gastric Mucosa Against Helicobacter pylori Infection and Gastric Cancer Development

      • Jun Nakayama
      Pages 111-124

    3. Sialylation and Immune Surveillance of Cancer by Siglecs

      • Bindu Mohan, Paul R. Crocker
      Pages 125-138

  6. Changes in the Organization of Complex Carbohydrates in Cancers

    1. Front Matter

      Pages 139-139
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    2. Expression and Function of Poly-N-Acetyllactosamine Type Glycans in Cancer

      • Motohiro Nonaka, Minoru Fukuda
      Pages 141-161

    3. Role of Glycans in Cancer Cell Death: A Deadly Relationship

      • Inka Brockhausen
      Pages 163-193

  7. Implication of Sugars in Cancer Diagnostics and Therapeutics

    1. Front Matter

      Pages 195-195
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    2. Targeting Glycans for Immunotherapy of Human Cancers

      • Jung-Tung Hung, Alice L. Yu
      Pages 197-219
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Keywords

About this book

This book is a collection of cutting-edge studies on the functions and mechanisms of glycosylation in cancers. Along with progress in genomics and proteomics, new findings in the significance of these complex carbohydrates, through the regulation of cell signals, have been elucidated in a wide variety of biological events. This volume provides a comprehensive summary of glycosignals and their involvement in cancer, covering numerous topics such as glycosylation machineries, regulation of phenotypes, cell signaling, immune regulation, complex carbohydrate organization, and clinical applications. The contents have been organized to promote ready understanding, covering basic to clinical research and studies on micromolecules, to animal/human cells and tissues. This book is an essential read for students and young researchers interested in cancers and carbohydrates. Specialists in glycobiology will also benefit from the new results and approaches detailed here, which provide insights into future directions of functional studies of sugar chains in both basic and applied research.

Editors and Affiliations

  • Biomedical Sciences, Chubu University, Kasugai, Japan

    Koichi Furukawa

  • Glycobiology Unit, Sanford-Burnham Med Res Inst, La Jolla, USA

    Minoru Fukuda

Bibliographic Information

  • Book Title: Glycosignals in Cancer: Mechanisms of Malignant Phenotypes

  • Editors: Koichi Furukawa, Minoru Fukuda

  • DOI: https://doi.org/10.1007/978-4-431-55939-9

  • Publisher: Springer Tokyo

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Japan 2016

  • Softcover ISBN: 978-4-431-56732-5Published: 31 March 2018

  • eBook ISBN: 978-4-431-55939-9Published: 26 January 2016

  • Edition Number: 1

  • Number of Pages: VIII, 219

  • Number of Illustrations: 24 b/w illustrations, 10 illustrations in colour

  • Topics: Biochemistry, general, Cancer Research, Cell Biology, Oncology

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