Systemic Sclerosis

1. Front Matter

   Pages i-viii

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2. Fibrosis: Overview

   • Hironobu Ihn

   Pages 1-20

3. Autoimmunity in Systemic Sclerosis: Overview

   • Ayumi Yoshizaki, Shinichi Sato

   Pages 21-37

4. Endothelial Progenitor Cells

   • Masataka Kuwana

   Pages 39-56

5. Animal Models of Systemic Sclerosis

   • Toshiyuki Yamamoto

   Pages 57-79

6. Genetics of Systemic Sclerosis

   • Naoyuki Tsuchiya, Aya Kawasaki

   Pages 81-92

7. Role of the Interleukin-1 Family in the Fibrogenic Phenotype in Systemic Sclerosis

   • Yasushi Kawaguchi

   Pages 93-102

8. Interleukin-6 in the Pathogenesis of Systemic Sclerosis

   • Yoshihito Shima

   Pages 103-115

9. Epigenetics

   • Masatoshi Jinnin

   Pages 117-136

10. Transforming Growth Factor-ß and Connective Tissue Growth Factor

    • Manabu Fujimoto, Kazuhiko Takehara

    Pages 137-153

11. Endothelin

    • Sei-ichiro Motegi

    Pages 155-171

12. The Role of B Cells in Systemic Sclerosis

    • Takashi Matsushita, Kazuhiko Takehara

    Pages 173-185

13. Fli1

    • Yoshihide Asano

    Pages 187-209

14. Biomarker

    • Minoru Hasegawa

    Pages 211-229

15. Autoantibodies in Systemic Sclerosis

    • Yasuhito Hamaguchi

    Pages 231-247

This book provides a comprehensive review of the recent advances in the research of systemic sclerosis (scleroderma). Systemic sclerosis is a complex autoimmune disease characterized by vasculopathy, fibrosis, and immune activation. This disease is also associated with certain susceptibility genes and is affected by epigenetic regulation. Recent studies have revealed a variety of new evidence suggestive of the pathogenesis of the disease. These include endothelial progenitor cells, cytokines and growth factors, and B cells. Studies using animal models have also provided novel insight into the pathomechanisms. In addition to these topics, the book covers clinical research regarding biomarkers and autoantibodies. This volume will benefit all rheumatologists and dermatologists as well as basic scientists, especially immunologists, molecular biologists, and biochemists.

• Autoimmune disease
• Cytokine
• Fibrosis
• Immune activation
• Scleroderma
• Vasculopathy

• Department of Dermatology, Kanazawa University, Kanazawa, Japan

  Kazuhiko Takehara

• Department of Dermatology, University of Tsukuba, Tsukuba, Japan

  Manabu Fujimoto

• Department of Allergy and Rheumatology, Nippon Medical School, Tokyo, Japan

  Masataka Kuwana

Dr. Kazuhiko Takehara
Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan

Dr. Manabu Fujimoto
Department of Dermatology, University of Tsukuba, Japan

Dr. Masataka Kuwana
Department of Allergy and Rheumatology, Nippon Medical School, Japan

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