Long Noncoding RNAs

1. Front Matter

   Pages i-viii

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2. Bioinformatics and Other Methodologies for lncRNAs

   1. Front Matter

      Pages 1-1

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   2. Complexity of Mammalian Transcriptome Analyzed by RNA Deep Sequencing

      • Aleks Schein, Piero Carninci

      Pages 3-22

   3. Synthetic Strategies to Identify and Regulate Noncoding RNAs

      • Ganesh N. Pandian, Junetha Syed, Hiroshi Sugiyama

      Pages 23-43

3. Atomic and Molecular Structures of lncRNAs

   1. Front Matter

      Pages 45-45

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   2. Structure and Interaction with Protein of Noncoding RNA: A Case for an RNA Aptamer Against Prion Protein

      • Masato Katahira

      Pages 47-56

   3. Characterization of G-Quadruplex DNA- and RNA-Binding Protein

      • Takanori Oyoshi

      Pages 57-65

4. Molecular Functions of lncRNAs

   1. Front Matter

      Pages 67-67

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   2. Initiation of Transcription Generates Divergence of Long Noncoding RNAs

      • Riki Kurokawa

      Pages 69-91

   3. Beneath the Veil of Biological Complexity There Lies Long Noncoding RNA: Diverse Utilization of lncRNA in Yeast Genomes

      • Tomohiro Kumon, Kunihiro Ohta

      Pages 93-110

   4. Long Noncoding RNAs as Structural and Functional Components of Nuclear Bodies

      • Taro Mannen, Takeshi Chujo, Tetsuro Hirose

      Pages 111-129

5. Biological Actions of lncRNAs

   1. Front Matter

      Pages 131-131

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   2. Long Noncoding RNA in Epigenetic Gene Regulation

      • Yuko Hasegawa, Shinichi Nakagawa

      Pages 133-149

   3. Mechanisms of Long Noncoding Xist RNA-Mediated Chromosome-Wide Gene Silencing in X-Chromosome Inactivation

      • Norishige Yamada, Yuya Ogawa

      Pages 151-171

6. Potential Outcomes for Clinical Medicine

   1. Front Matter

      Pages 173-173

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   2. Regulation of pRB and p53 Pathways by the Long Noncoding RNAs ANRIL, lincRNA-p21, lincRNA-RoR, and PANDA

      • Yojiro Kotake, Masatoshi Kitagawa

      Pages 175-189

   3. The Role of Androgen-Regulated Long Noncoding RNAs in Prostate Cancer

      • Ken-ichi Takayama, Satoshi Inoue

      Pages 191-210

   4. Macrophage Activation as a Model System for Understanding Enhancer Transcription and eRNA Function

      • Karmel A. Allison, Christopher K. Glass

      Pages 211-229

   5. Long Noncoding RNA Functions as a Regulator for Steroid Hormone Receptor-Related Breast and Prostate Cancers

      • Chunyu Jin, Michael G. Rosenfeld

      Pages 231-249

7. Back Matter

   Pages 251-257

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This book presents a common principle of actions of long noncoding RNAs (lncRNAs) from points of view at the atomic, molecular and cellular levels. At the atomic level, chemical studies of ribonucleic acids explain the chemical behavior of lncRNAs. Structural biological analysis of lncRNAs and its binding proteins also reveal the precise mechanisms of their actions. Molecular biological approaches lead to insights into molecular mechanisms of these lncRNA actions. At the cellular or individual level of analysis, we grasp the biology and medicine of lncRNAs. These three layers of approaches are thoroughly new and produce novel insights into functions of lncRNAs in living cells. The book consists of five parts: 1) Bioinformatics and other methodologies for lncRNAs, 2) Atomic and molecular structures of lncRNAs, 3) Molecular functions of lncRNAs, 4) Biological actions of lncRNAs, and 5) Potential outcomes for clinical medicine. These sections connect well and work synergistically. The book is for researchers whose specialty is RNA biology and chemistry and also for advanced students at the graduate and undergraduate levels. Readers can grasp the leading edge of lncRNA studies in a comprehensive manner and are inspired to pursue their own particular interests.

• Bioinformatics
• Chemical biology
• Epigenetics
• Macrophage
• RNA medicine
• Steroid hormone
• Transcription
• X-chromosome inactivation
• lncRNA

“The book ‘Long Noncoding RNAs Structures and Functions’ introduces long noncoding RNAs (lncRNAs) and outlines molecular mechanisms of their activity and potential biological function, mostly associated with transcriptional or epigenetic regulation. … This book reflects needs of understanding of lncRNAs function and provides a valuable summary of available information.” (Dana Jurkovicova, Neoplasma, Vol. 63 (2), 2016)

• Division of Gene Structure and Function, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan

  Riki Kurokawa

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