Overview
- Editors:
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Jun-ichiro Inoue
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Division of Cellular & Molecular Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
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Mutsuhiro Takekawa
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The Institute of Medical Science Division of Cell Signaling & Molecular Medicine, The University of Tokyo, Tokyo, Japan
Discusses cutting-edge methodologies and integrated interdisciplinary approaches to the study of post-translational modifications that regulate critical cellular signal pathways
Draws together recently identified regulatory mechanisms and biological roles of cell signaling, with recent advances in our understanding of the molecular basis of human diseases
Is written by leading experts in the fields of cell signaling and post-translational modifications
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Table of contents (20 chapters)
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Novel Analytical Procedures for Signal Transduction
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- Hiroko Kozuka-Hata, Masaaki Oyama
Pages 3-15
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- Eiji Kinoshita, Emiko Kinoshita-Kikuta, Tohru Koike
Pages 17-30
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- Hirotaka Takahashi, Keiichirou Nemoto, Ramadan Abdelaziz, Atsushi Uematsu, Tatsuya Sawasaki
Pages 43-60
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Mathematical Simulation of Signal Transduction
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- Daisuke Ohshima, Jun-ichiro Inoue, Kazuhisa Ichikawa
Pages 63-75
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- Daisuke Ohshima, Kyoko Arimoto-Matsuzaki, Taichiro Tomida, Mutsuhiro Takekawa, Kazuhisa Ichikawa
Pages 77-93
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- Hiroyuki Kubota, Shinya Kuroda
Pages 95-109
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Structural Analysis of Signal Transduction
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Front Matter
Pages 111-111
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- Kazuki Kato, Hiroshi Nishimasu, Ryohei Ishii, Osamu Nureki, Ryuichiro Ishitani
Pages 113-125
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- Teruya Nakamura, Yohei Mukai, Yasuo Tsutsumi, Yuriko Yamagata
Pages 127-141
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Regulation of Signal Transduction by Post-translational Modifications and Its Pathogenic Dysregulation
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Front Matter
Pages 157-157
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- Yuu Taguchi, Jin Gohda, Jun-ichiro Inoue
Pages 197-210
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- Mutsuhiro Takekawa, Yuji Kubota
Pages 211-231
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- Atsushi Enomoto, Liang Weng, Masahide Takahashi
Pages 233-250
About this book
This book is devoted to recent advances in analysis of the molecular basis and dynamics of post-translational modifications (PTMs) of proteins for a comprehensive understanding of their key roles in cell signaling networks and diverse biological processes, and their perturbation in a variety of life-threatening diseases such as cancer and inflammatory diseases. The book includes research regarding PTMs and methods of their investigation derived from interdisciplinary collaborations between leading scientists in the fields of molecular, medical, proteomic, structural, and mathematical biology. This book consists of four sections. The first part focuses on recent advances in procedures for analysis of PTMs and cell signaling. The second part is devoted to mathematical simulation of signal transduction pathways and of the formation of protein complexes in living cells. The third part deals with structural and functional analyses of proteins involved in the regulation of PTMs and cell signaling. The fourth part describes cutting-edge findings regarding critical signal transduction pathways and their dysregulation in human diseases. This book is aimed at both established scientists and students in various fields of biology including molecular, cellular, structural, proteomic, and mathematical biology. Readers can access cutting-edge research and methodologies in their own field as well as interdisciplinary research that impacts on their field. The book can function as a reference for pharmaceutical scientists, biomedical researchers, and clinicians for the development of molecular-targeted therapy of human diseases.
Editors and Affiliations
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Division of Cellular & Molecular Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
Jun-ichiro Inoue
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The Institute of Medical Science Division of Cell Signaling & Molecular Medicine, The University of Tokyo, Tokyo, Japan
Mutsuhiro Takekawa