Protein Modifications in Pathogenic Dysregulation of Signaling

1. Front Matter

   Pages i-ix

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2. Novel Analytical Procedures for Signal Transduction

   1. Front Matter

      Pages 1-1

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   2. Phosphoproteomics-Based Network Analysis of Cancer Cell Signaling Systems

      • Hiroko Kozuka-Hata, Masaaki Oyama

      Pages 3-15

   3. Phos-tag-Based Affinity Chromatography Techniques for Enrichment of the Phosphoproteome

      • Eiji Kinoshita, Emiko Kinoshita-Kikuta, Tohru Koike

      Pages 17-30

   4. Visualization of Intracellular Signaling with Fluorescence Resonance Energy Transfer-Based Biosensors

      • Kazuhiro Aoki

      Pages 31-41

   5. Technology of Wheat Cell-Free-Based Protein Array for Biochemical Analyses of Protein Kinases and Ubiquitin E3 Ligases

      • Hirotaka Takahashi, Keiichirou Nemoto, Ramadan Abdelaziz, Atsushi Uematsu, Tatsuya Sawasaki

      Pages 43-60

3. Mathematical Simulation of Signal Transduction

   1. Front Matter

      Pages 61-61

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   2. Potential Roles of Spatial Parameters in the Regulation of NF-κB Oscillations, as Revealed by Computer Simulations

      • Daisuke Ohshima, Jun-ichiro Inoue, Kazuhisa Ichikawa

      Pages 63-75

   3. Stochastic Simulation of Stress Granules

      • Daisuke Ohshima, Kyoko Arimoto-Matsuzaki, Taichiro Tomida, Mutsuhiro Takekawa, Kazuhisa Ichikawa

      Pages 77-93

   4. Temporal Coding of Insulin Signaling

      • Hiroyuki Kubota, Shinya Kuroda

      Pages 95-109

4. Structural Analysis of Signal Transduction

   1. Front Matter

      Pages 111-111

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   2. Structural Biology of Protein Post-transcriptional Modifications and Cellular Signaling

      • Kazuki Kato, Hiroshi Nishimasu, Ryohei Ishii, Osamu Nureki, Ryuichiro Ishitani

      Pages 113-125

   3. Structural Basis for Signal Initiation by TNF and TNFR

      • Teruya Nakamura, Yohei Mukai, Yasuo Tsutsumi, Yuriko Yamagata

      Pages 127-141

   4. Regulation of NF-κB Pathway by Linkage-Specific Ubiquitin-Binding Domains

      • Yusuke Sato

      Pages 143-155

5. Regulation of Signal Transduction by Post-translational Modifications and Its Pathogenic Dysregulation

   1. Front Matter

      Pages 157-157

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   2. NF-κB Signaling and Lymphoid Malignancies

      • Shoji Yamaoka

      Pages 159-175

   3. Ubiquitination-Mediated NF-κB Regulation in Inflammatory Response

      • Fuminori Tokunaga

      Pages 177-196

   4. NF-κB Signaling in Osteoclastogenesis

      • Yuu Taguchi, Jin Gohda, Jun-ichiro Inoue

      Pages 197-210

   5. Mitogen-Activated Protein Kinase Signaling and Cancer

      • Mutsuhiro Takekawa, Yuji Kubota

      Pages 211-231

   6. Critical Roles of the AKT Substrate Girdin in Disease Initiation and Progression

      • Atsushi Enomoto, Liang Weng, Masahide Takahashi

      Pages 233-250

This book is devoted to recent advances in analysis of the molecular basis and dynamics of post-translational modifications (PTMs) of proteins for a comprehensive understanding of their key roles in cell signaling networks and diverse biological processes, and their perturbation in a variety of life-threatening diseases such as cancer and inflammatory diseases. The book includes research regarding PTMs and methods of their investigation derived from interdisciplinary collaborations between leading scientists in the fields of molecular, medical, proteomic, structural, and mathematical biology. This book consists of four sections. The first part focuses on recent advances in procedures for analysis of PTMs and cell signaling. The second part is devoted to mathematical simulation of signal transduction pathways and of the formation of protein complexes in living cells. The third part deals with structural and functional analyses of proteins involved in the regulation of PTMs and cell signaling. The fourth part describes cutting-edge findings regarding critical signal transduction pathways and their dysregulation in human diseases. This book is aimed at both established scientists and students in various fields of biology including molecular, cellular, structural, proteomic, and mathematical biology. Readers can access cutting-edge research and methodologies in their own field as well as interdisciplinary research that impacts on their field. The book can function as a reference for pharmaceutical scientists, biomedical researchers, and clinicians for the development of molecular-targeted therapy of human diseases.

• Cell signaling
• Interdisciplinary collaboration
• Molecular pathophysiology
• Post-translational modifications
• Signal transduction

• Division of Cellular & Molecular Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

  Jun-ichiro Inoue

• The Institute of Medical Science Division of Cell Signaling & Molecular Medicine, The University of Tokyo, Tokyo, Japan

  Mutsuhiro Takekawa

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