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Molecular Mechanisms in the Pathogenesis of Idiopathic Nephrotic Syndrome

  • Book
  • © 2016

Overview

Editors:
  1. Kazunari Kaneko

    1. Department of Pediatrics, Kansai Medical University, Hirakata, Osaka, Japan

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  • Brings together all of the latest research by top researchers on molecular mechanisms in the pathogenesis of INS

  • Represents one putative pathogenetic molecule in each chapter and reviews its role, mechanism, and prospects as a biomaker or for new drugs

  • Provides valuable reading for physicians, pediatricians, nephrologists, and individuals researching nephrotic syndrome

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-viii
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  2. Introduction

    1. Front Matter

      Pages 1-1
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    2. History of Research on Pathogenesis of Idiopathic Nephrotic Syndrome

      • Kazunari Kaneko
      Pages 3-10

  3. Minimal-Change Nephrotic Syndrome (MCNS)

    1. Front Matter

      Pages 11-11
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    2. Hemopexin in Minimal Change Nephrotic Syndrome

      • Yasuko Kobayashi, Moin A. Saleem
      Pages 13-23

    3. Angiopoietin-Like 4 (Angptl4) in MCNS

      • Lionel C. Clément
      Pages 25-43

    4. Co-stimulatory Molecule CD80 (B7.1) in MCNS

      • Michiko Shimada, Takuji Ishimoto, Richard J. Johnson
      Pages 45-62

    5. Energy and Mammalian Target of Rapamycin Complex 1 (mTORC1) in Minimal Change Nephrotic Syndrome

      • Kunimasa Yan
      Pages 63-79

    6. The Role of c-mip in the Pathogenesis of Minimal Change Nephrotic Syndrome

      • Vincent Audard, André Pawlak, Dil Sahali
      Pages 81-91

    7. Regulatory T Cells and Oxidative Stress in Minimal Change Nephropathy

      • Roberta Bertelli, Armando Di Donato, Alice Bonanni, Roberta Rossi, Pietro Ravani, Gian Marco Ghiggeri
      Pages 93-103

    8. Cytokines as Active Factors in Minimal Change Nephrotic Syndrome

      • Gabriel M. Cara-Fuentes, Richard J. Johnson, Eduardo H. Garin
      Pages 105-140

  4. Focal Segmental Glomerulosclerosis (FSGS)

    1. Front Matter

      Pages 141-141
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    2. Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR) in Focal Segmental Glomerulosclerosis

      • Jochen Reiser, Nada Alachkar
      Pages 143-154

    3. Cytokines as Active Factors in Focal Segmental Glomerulosclerosis

      • Gabriel M. Cara-Fuentes, Richard J. Johnson, Eduardo H. Garin
      Pages 155-178

  5. Idiopathic Membranous Nephropathy (IMN)

    1. Front Matter

      Pages 179-179
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    2. M-type Phospholipase A2 Receptor (PLA2R) and Thrombospondin Type-1 Domain-Containing 7A (THSD7A) in Membranous Nephropathy

      • Laurence H. Beck, Sanjeev Sethi, Fernando C. Fervenza
      Pages 181-205

    3. Cationic Bovine Serum Albumin as Cause of Membranous Nephropathy: From Mice to Men

      • Markus J. Kemper, Jun Oh
      Pages 207-217

  6. Treatment in Idiopathic Nephrotic Syndrome

    1. Front Matter

      Pages 219-219
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    2. Podocytes as a Direct Target of Drugs Used in Idiopathic Nephrotic Syndrome

      • Lulu Jiang, Peter W. Mathieson, Gavin I. Welsh
      Pages 221-240
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Keywords

About this book

This comprehensive book reviews our current state of knowledge about the pathogenesis of idiopathic nephrotic syndrome (INS), which comprises a heterogeneous group of diseases with distinct histological characteristics, such as minimal-change nephrotic syndrome (MCNS), focal segmental glomerulosclerosis (FSGS), and idiopathic membranous nephropathy (IMN). As the word “idiopathic” indicates, the pathogenesis of INS remains unclear. Historically, T-cell dysfunction has been thought to play an important part in the pathogenesis of MCNS, while circulating vascular permeabilities have been believed to induce proteinuria in FSGS. The book further describes recent advances in molecular biology, which have allowed us to speculate on the interactions between visceral glomerular epithelial cells (podocytes) and the relative significance of several molecules in the pathogenesis of INS, such as reactive oxygen species, nuclear factor-kappa B, CD80, angiopoietin-like 4, cardiotrophin-like cytokine-1, and M-type phospholipase A2 receptor. The normally rapid pace of scientific progress occasionally devolves into a state of chaos, and the pathogenetic research on INS is one such case. This volume will help researchers and scientists to collaborate, share resources, and expedite the design of protocols to evaluate the putative factors.

Editors and Affiliations

  • Department of Pediatrics, Kansai Medical University, Hirakata, Osaka, Japan

    Kazunari Kaneko

Bibliographic Information

  • Book Title: Molecular Mechanisms in the Pathogenesis of Idiopathic Nephrotic Syndrome

  • Editors: Kazunari Kaneko

  • DOI: https://doi.org/10.1007/978-4-431-55270-3

  • Publisher: Springer Tokyo

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Japan 2016

  • Hardcover ISBN: 978-4-431-55269-7Published: 25 November 2015

  • Softcover ISBN: 978-4-431-56279-5Published: 23 August 2016

  • eBook ISBN: 978-4-431-55270-3Published: 26 October 2015

  • Edition Number: 1

  • Number of Pages: VIII, 240

  • Number of Illustrations: 5 b/w illustrations, 16 illustrations in colour

  • Topics: Nephrology, Urology, Molecular Medicine

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