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  • © 2014

Neuroprotection and Neuroregeneration for Retinal Diseases

  • Offers the latest information on neuroprotection and regeneration for various eye diseases

  • Treats both theoretical and practical aspects of the disease mechanisms and treatments

  • Exhaustively reviews the key recent research into each eye disease by leading authors

  • Includes supplementary material: sn.pub/extras

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Hardcover Book USD 169.99
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Table of contents (23 chapters)

  1. Front Matter

    Pages i-x
  2. Neuroprotection for Glaucoma

    1. Front Matter

      Pages 1-1
    2. Calcium and Calpain Activation

      • Morin Ryu, Toru Nakazawa
      Pages 13-24
    3. Classical Signaling Pathways

      • Hideki Hayashi
      Pages 25-41
    4. ER Stress

      • Masamitsu Shimazawa, Hideaki Hara
      Pages 67-83
    5. Neurotrophic Factors

      • Chikako Harada, Takayuki Harada
      Pages 99-112
    6. RIP Kinase-Mediated Programmed Necrosis

      • Yusuke Murakami, Maki Kayama, Joan W. Miller, Demetrios Vavvas
      Pages 113-122
    7. Axonal Degeneration

      • Yasushi Kitaoka
      Pages 123-131
    8. Axonal Transport

      • Yuji Takihara, Masaru Inatani
      Pages 133-141
    9. Interaction Between RGC Bodies and Glia

      • Kenji Kashiwagi
      Pages 143-160
    10. Aquaporin in Optic Neuropathies

      • Akiyasu Kanamori
      Pages 161-173
    11. Microglia

      • Yuki Fujita, Toshihide Yamashita
      Pages 175-187
  3. Neuroprotection for Age-Related Macular Degeneration (AMD), Retinal Pigmentary Degeneration

    1. Front Matter

      Pages 189-189
    2. Neuroprotection for Photoreceptors

      • Toshiaki Abe, Nobuhiro Nagai
      Pages 191-204
    3. Roles of the Retinal Pigment Epithelium in Neuroprotection

      • Atsuhiro Kanda, Susumu Ishida
      Pages 227-238

About this book

This book provides the latest findings on neuroprotection and neuroregeneration as potential therapeutic strategies for various eye diseases, namely, glaucoma, age-related macular degeneration (AMD), retinal detachment, and retinitis pigmentosa. Glaucoma is one of the main causes of blindness throughout the world, and other diseases such as AMD and retinitis pigmentosa also lead to loss of vision. All these conditions are characterized by degeneration of specific retinal cell types, making it essential to establish treatments to protect retinal neurons and the optic nerve.

With that aim in mind, this book explains the mechanisms underlying aforementioned diseases and their experimental models. The novel strategy proposals for the treatment of retinal diseases based on the concept of neuroprotection are also discussed in the main body of the text, while the section on regenerative research discusses optic nerve regeneration, endothelial progenitor cells, and iPS cells.

This book is recommended as a professional reference work for all doctors and trainees in the field of ophthalmology who are interested in neuroprotective and neuroregenerative treatments.

Reviews

“The book summarizes and reviews recent research findings regarding neuroprotection and neuroregeneration for the treatment of macular degeneration, glaucoma, and retinal diseases. … The intended audience is medical students, researchers, and ophthalmologists interested in ongoing ophthalmologic research. … most likely will appeal to ophthalmologists specializing in retinal diseases or glaucoma and to ophthalmologic researchers. … This is a useful review of the current literature and a convenient summary of ongoing research into macular degeneration, glaucoma, and retinal disease.” (Caroline Minkus, Doody's Book Reviews, August, 2015)

“This is a great book on the molecular and cellular pathways in retinal diseases and their regeneration through gene, RNA, DNA, and hormonal interventions in human and animal models. … I recommend this book to ophthalmologists, eye researcher, and physicians with an interest in Retina will benefit greatly.” (Joseph J. Grenier, Amazon.com, October, 2014)

Editors and Affiliations

  • Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan

    Toru Nakazawa

  • Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Japan

    Yasushi Kitaoka

  • Visual Research Project, Tokyo Metropolitan Inst of Med Sci, Tokyo, Japan

    Takayuki Harada

About the editors

Dr. Toru Nakazawa, MD, PhD.
Department of Ophthalmology Tohoku University Graduate School of Medicine
1-1 Seiryo-cho Aoba-ku Sendai-shi Miyagi-ken 980-8574, Japan

Dr. Yasushi Kitaoka, MD, PhD.
Department of Ophthalmology, St. Marianna University School of Medicine
2-16-1 Sugao, Kawasaki-shi, Kanagawa 216-8511, Japan

Dr. Takayuki Harada, MD, PhD.
Visual Research Project Tokyo Metropolitan Institute of Medical Science
2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan

Bibliographic Information

  • Book Title: Neuroprotection and Neuroregeneration for Retinal Diseases

  • Editors: Toru Nakazawa, Yasushi Kitaoka, Takayuki Harada

  • DOI: https://doi.org/10.1007/978-4-431-54965-9

  • Publisher: Springer Tokyo

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Japan 2014

  • Hardcover ISBN: 978-4-431-54964-2Published: 11 August 2014

  • Softcover ISBN: 978-4-431-56192-7Published: 27 September 2016

  • eBook ISBN: 978-4-431-54965-9Published: 23 July 2014

  • Edition Number: 1

  • Number of Pages: X, 356

  • Number of Illustrations: 24 b/w illustrations, 61 illustrations in colour

  • Topics: Ophthalmology, Neurology, Regenerative Medicine/Tissue Engineering

Buy it now

Buying options

eBook USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access