Overview
- Nominated as an outstanding Ph.D thesis by Kyoto University
- Includes many references and ample experimental procedures
- Written in a manner that can be easily understood also by researchers in fields of chemistry other than synthetic chemistry
- Includes supplementary material: sn.pub/extras
Part of the book series: Springer Theses (Springer Theses)
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Table of contents (4 chapters)
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Front Matter
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Back Matter
Keywords
About this book
This work describes novel, effective hydrogen-bond (HB) donor catalysts based on a known bifunctional tertiary amine-thiourea, a privileged structure, which has been proven to be one of the most widely used organocatalysts. These HB donor catalysts derived from quinazoline and benzothiadiazine were initially synthesized as novel HB donors with their HB-donating abilities being measured by analytical methods. They were found to be effective for a variety of asymmetric transformations including Michael reactions of a, b-unsaturated imides and hydrazination reactions of 1,3-dicarbonyl compounds. Thiourea catalysts that have an additional functional group are also described. Specifically, thioureas that bear a hydroxyl group were synthesized and subsequently used as novel bifunctional organocatalysts for catalytic, asymmetric Petasis-type reactions involving organoboronic acids as nucleophiles. These addition reactions were difficult to achieve using existing organocatalysts. One of the developed catalytic methods can be applied to the synthesis of biologically interesting peptide-derived compounds possessing unnatural vinyl glycine moieties. These findings introduce new criteria required for the development of organocatalysts for asymmetric reactions, thus making a significant contribution to the field of organocatalysis.
Authors and Affiliations
About the author
Dr. Tsubasa Inokuma,
The Scripps Research Institute
Tsubasa Inokuma was born in Okayama in 1983. He studied chemistry at Kyoto University and obtained BSc (2005) and MSc (2007) degree at Kyoto University under the guidance of Prof. Yoshiji Takemoto. In 2008, during his PhD course, he became an assistant professor at Kyoto University. He obtained PhD degree at Kyoto University in 2011 under the supervision of Prof. Yoshiji Takemoto. Since 2012, he has been working as a postdoctoral fellow in Barbas laboratory at The Scripps Research Institute. His research interests are development of novel catalytic reaction and bioconjugation methods.
Bibliographic Information
Book Title: Development of Novel Hydrogen-Bond Donor Catalysts
Authors: Tsubasa Inokuma
Series Title: Springer Theses
DOI: https://doi.org/10.1007/978-4-431-54231-5
Publisher: Springer Tokyo
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: Springer Japan 2013
Hardcover ISBN: 978-4-431-54230-8Published: 18 January 2013
Softcover ISBN: 978-4-431-54745-7Published: 01 July 2015
eBook ISBN: 978-4-431-54231-5Published: 18 January 2013
Series ISSN: 2190-5053
Series E-ISSN: 2190-5061
Edition Number: 1
Number of Pages: XIV, 107
Topics: Organic Chemistry, Medicinal Chemistry, Catalysis