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  • © 2006

Sphingolipid Biology

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Table of contents (39 chapters)

  1. Front Matter

    Pages i-xxvi
  2. Overview

    1. Front Matter

      Pages 1-1
    2. Sphingolipids Synthesis, Transport and Cellular Signaling

      • Yoshio Hirabayashi, Yasuyuki Igarashi, Alfred H. Merrill Jr.
      Pages 3-22
  3. Biosynthesis, Transport of Sphingolipids

    1. Front Matter

      Pages 23-23
    2. Serine Palmitoyltransferase

      • Jia Wei, Tokumbo Yerokun, Martina Liepelt, Amin Momin, Elaine Wang, Kentaro Hanada et al.
      Pages 25-47
    3. Ceramide Synthase

      • Irene Pankova-Kholmyansky, Anthony H. Futerman
      Pages 49-56
    4. Dihydroceramide: Sphinganine Δ4-Desaturase and C4-Hydroxylase

      • Akemi Suzuki, Fumio Omae, Ayako Enomoto
      Pages 57-68
    5. Synthesis, Metabolism, and Trans-Bilayer Movement of Long-Chain Base

      • Akio Kihara, Yasuyuki Igarashi
      Pages 95-106
    6. Sphingolipid Trafficking

      • Kouichi Funato, Howard Riezman
      Pages 123-139
    7. Current Perspectives on Saccharomyces cerevisiae Sphingolipids

      • Robert C. Dickson, Robert L. Lester
      Pages 141-150
  4. Generation and Degradation of Sphingolipid Signaling Molecules

    1. Front Matter

      Pages 151-151
    2. Generation of Signaling Molecules by De Novo Sphingolipid Synthesis

      • Kazuyuki Kitatani, L. Ashley Cowart, Yusuf A. Hannun
      Pages 153-165
    3. Overview of Acid and Neutral Sphingomyelinases in Cell Signaling

      • Youssef Zeidan, Norma Marchesini, Yusuf A. Hannun
      Pages 167-181
    4. Activation of Sphingosine Kinase 1

      • Michael Maceyka, Sergio E. Alvarez, Sheldon Milstien, Sarah Spiegel
      Pages 197-206
    5. Ceramide 1-Phosphate

      • Susumu Mitsutake, Tack-Joong Kim, Yasuyuki Igarashi
      Pages 207-218
    6. Sphingosine-1-Phosphate Lyase

      • Julie D. Saba
      Pages 219-230

About this book

Sphingolipids are fundamental to the structures of cell membranes, lipoproteins, and the stratum cornea of the skin. Many complex sphingolipids as well as simpler sphingoid bases and derivatives are highly bioactive as extra- and intracellular regulators of growth, differentiation, migration, survival, senescence, and numerous cellular responses to stress. This book provides many examples of exciting new developments in sphingolipid biology/sphingolipidology that are changing our understanding of how multicellular organisms grow, develop, function, age, and die. Key areas addressed include sphingolipid biosynthesis, transport and membrane organization/lipid rafts; genetic approaches to understanding the roles of membrane sphingolipid biosynthesis; sphingolipid metabolism, specific G protein-coupled receptors (GPCRs), and signal transduction; and sphingolipid-associated disease and drug development.

Editors and Affiliations

  • Brain Science Institute, The Institute of Physical and Chemical Research (Riken), Saitama, Japan

    Yoshio Hirabayashi

  • Department of Biomembrane and Biofunctional Chemistry, Faculty of Advanced Life Science and Graduate School of Life Science, Hokkaido University, Sapporo, Japan

    Yasuyuki Igarashi

  • School of Biology and the Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, USA

    Alfred H. Merrill

Bibliographic Information

  • Book Title: Sphingolipid Biology

  • Editors: Yoshio Hirabayashi, Yasuyuki Igarashi, Alfred H. Merrill

  • DOI: https://doi.org/10.1007/4-431-34200-1

  • Publisher: Springer Tokyo

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Tokyo 2006

  • Hardcover ISBN: 978-4-431-34198-7Published: 19 July 2006

  • Softcover ISBN: 978-4-431-54666-5Published: 02 December 2014

  • eBook ISBN: 978-4-431-34200-7Published: 31 December 2007

  • Edition Number: 1

  • Number of Pages: XXV, 531

  • Topics: Cell Biology, Biochemistry, general

Buy it now

Buying options

eBook USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access