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Serotonin and Sleep: Molecular, Functional and Clinical Aspects

  • Book
  • © 2008

Overview

Editors:
  1. Jaime M. Monti

    1. Pharmacology and Therapeutics, School of Medicine, Clinics Hospital, Montevideo, Uruguay

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  2. S. R. Pandi-Perumal

    1. Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, USA

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  3. Barry L. Jacobs

    1. Green Hall, Program in Neuroscience, Princeton University, Princeton, USA

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  4. David J. Nutt

    1. Psychopharmacology Unit, Bristol, UK

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  • Overview of current approaches and medications
  • Up-to-date reference resource
  • Interesting and readable
  • Includes supplementary material: sn.pub/extras

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Table of contents (24 chapters)

  1. Front Matter

    Pages I-XXVIII
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  2. Evolution of concepts

    1. Front Matter

      Pages 1-1
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    2. Changing concepts on the role of serotonin in the regulation of sleep and waking

      • Reidun Ursin
      Pages 3-21

  3. The dorsal raphe nucleus and median raphe nucleus: organization and projections

    1. Front Matter

      Pages 23-23
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    2. Topographic organization and chemoarchitecture of the dorsal raphe nucleus and the median raphe nucleus

      • Christopher A. Lowry, Andrew K. Evans, Paul J. Gasser, Matthew W. Hale, Daniel R. Staub, Anantha Shekhar
      Pages 25-67

    3. Efferent and afferent connections of the dorsal and median raphe nuclei in the rat

      • Robert P. Vertes, Stephanie B. Linley
      Pages 69-102

    4. Reciprocal connections between the suprachiasmatic nucleus and the midbrain raphe nuclei: A putative role in the circadian control of behavioral states

      • Samüel Deurveilher, Kazue Semba
      Pages 103-131

  4. Serotonin receptors

    1. Front Matter

      Pages 133-133
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    2. Localization of 5-HT receptors in the mammalian cortex

      • Noemí Santana, Julián de Almeida, Guadalupe Mengod, Francesc Artigas
      Pages 135-153

    3. Molecular biology of 5-HT receptors

      • Jason Hannon, Daniel Hoyer
      Pages 155-182

  5. Electrophysiology of serotonergic neurons and the regulation of serotonin release

    1. Front Matter

      Pages 183-183
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    2. Brain serotonergic neuronal activity in behaving cats

      • Barry L. Jacobs, Casimir A. Fornal
      Pages 185-204

    3. Electrophysiological studies on serotonergic neurons and sleep

      • Kazuya Sakai
      Pages 205-236

    4. Role and origin of the GABAergic innervation of dorsal raphe serotonergic neurons

      • Pierre-Hervé Luppi, Damien Gervasoni, Christelle Peyron, Lucienne Leger, Denise Salvert, Patrice Fort
      Pages 237-250

    5. Regulation of serotonin release by inhibitory and excitatory amino acids

      • Sidney B. Auerbach
      Pages 251-285

    6. Neurophysiological aspects of the regulation of serotonin neurons by the orexinergic system

      • Christopher M. Sinton
      Pages 287-304

  6. Serotonin receptors and the regulation of behavioural state

    1. Front Matter

      Pages 305-305
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    2. Serotonin and dreaming

      • Edward F. Pace-Schott
      Pages 307-324

    3. Involvement of the 5-HT1A and the 5-HT1B receptor in the regulation of sleep and waking

      • Chiara M. Portas, Janne Grønli
      Pages 325-369

    4. Mechanisms involved in the inhibition of REM sleep by serotonin

      • Jaime M. Monti, Héctor Jantos
      Pages 371-385
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Keywords

About this book

Foreword Barry Jacobs once memorably commented that the problem in understanding the role of serotonin in the brain was that it was implicated in virtually eve- thing but responsible for nothing [1]. Serotonin (5-HT) is defnitely implicated in the regulation of sleep but what does it do? Once seen as a sleep-promoting molecule, Jacob’s own work, lucidly described in this volume, radically changed our view. In fact, serotonin neurons are most active during waking; their - tivity diminishes with sleep onset and disappears during rapid eye movement (REM) sleep. Serotonin, therefore, is intimately linked to the sleep-wake cycle, but what is its role, what mechanisms are involved and what are the impli- tions for sleep medicine and psychiatry? Making progress with these diffcult questions requires a “translational” approach, which is a research paradigm where both laboratory and clinical neuroscience inform and guide each other with the ultimate aim of improving understanding and treatment of medical conditions. This volume is a superb example of translational research, where leading basic and clinical scientists - tegrate molecular, neuropharmacological and systems approaches to illuminate the reciprocal interactions of serotonin neurons and the mechanisms involved in sleep and circadian regulation. Serotonin is an ancient chemical mediator preserved through at least 500 m- lion years of evolution. In invertebrate animals such as mollusks and leeches, 5-HT cells are distributed throughout the nervous system among the various ganglia.

Editors and Affiliations

  • Pharmacology and Therapeutics, School of Medicine, Clinics Hospital, Montevideo, Uruguay

    Jaime M. Monti

  • Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, USA

    S. R. Pandi-Perumal

  • Green Hall, Program in Neuroscience, Princeton University, Princeton, USA

    Barry L. Jacobs

  • Psychopharmacology Unit, Bristol, UK

    David J. Nutt

Bibliographic Information

  • Book Title: Serotonin and Sleep: Molecular, Functional and Clinical Aspects

  • Editors: Jaime M. Monti, S. R. Pandi-Perumal, Barry L. Jacobs, David J. Nutt

  • DOI: https://doi.org/10.1007/978-3-7643-8561-3

  • Publisher: Birkhäuser Basel

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Birkhäuser Basel 2008

  • Hardcover ISBN: 978-3-7643-8560-6Published: 17 December 2007

  • eBook ISBN: 978-3-7643-8561-3Published: 04 March 2008

  • Edition Number: 1

  • Number of Pages: XXVIII, 621

  • Number of Illustrations: 77 b/w illustrations, 3 illustrations in colour

  • Topics: Pharmacology/Toxicology, Molecular Medicine, Human Physiology, Neurosciences

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