Inflammatory Cardiomyopathy (DCMi) - Pathogenesis and Therapy

1. Front Matter

   Pages i-xii

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2. Myocarditis and inflammatory cardiomyopathy — clinical management, epidemiology and prognosis

   1. Front Matter

      Pages 1-1

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   2. Pathogenesis, diagnosis and treatment of pericarditis

      • Bernhard Maisch, Konstantinos Karatolios, Sabine Pankuweit, Arsen Ristic

      Pages 3-24

   3. Epidemiology and Prognosis of Myocarditis and dilated Cardiomyopathy: Predictive Value of Clinical Parameters and Biopsy Findings

      • G. William Dec

      Pages 25-34

3. Animal models of myocarditis — autoimmunity and viral infection; therapeutic interventions

   1. Front Matter

      Pages 35-35

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   2. Autoimmune Murine Myocarditis and Immunomodulatory Interventions

      • Christoph Berger, Urs Eriksson

      Pages 37-49

   3. Coxsackievirus-induced murine myocarditis and immunomodulatory interventions

      • Michel Noutsias, Peter Liu

      Pages 51-69

   4. Myocardial Proteases and Matrix Remodeling in Acute Myocarditis and Inflammatory Cardiomyopathy

      • Susanne Rutschow, Michel Noutsias, Matthias Pauschinger

      Pages 71-88

4. Alterations of the immune system in human viral and inflammatory cardiomyopathy

   1. Front Matter

      Pages 89-89

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   2. Molecular genetics of cardiomyopathies and myocarditis

      • Jeffrey A. Towbin, Matteo Vatta

      Pages 91-156

   3. Pathogenic relevance of autoantibodies in dilated cardiomyopathy

      • Roland Jahns, Valérie Boivin, Georg Ertl, Martin J. Lohse

      Pages 157-170

   4. The role of cytokines in inflammation-induced cardiomyopathy: Pathogenesis and therapeutic implications

      • Jesus G. Vallejo, Douglas L. Mann

      Pages 171-181

5. Diagnosis of inflammatory and viral cardiomyopathy

   1. Front Matter

      Pages 183-183

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   2. Histology and immunohistology of myocarditis

      • Annalisa Angelini, Fiorella Calabrese, Gaetano Thiene

      Pages 185-199

   3. Immunohistological diagnosis of inflammatory cardiomyopathy and diagnosis of cardiotropic viral infections

      • Michel Noutsias, Heinz-Peter Schultheiss, Uwe Kühl

      Pages 201-225

   4. Cardiac magnetic resonance imaging: A non-invasive approach for the detection of myocardial inflammation — Potentials and limitations

      • Matthias Gutberlet

      Pages 227-235

6. Treatment strategies in inflammatory cardiomyopathy patients

   1. Front Matter

      Pages 237-237

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   2. Clinical management of acute myocarditis and cardiomyopathy

      • Kenneth L. Baughman

      Pages 239-255

   3. Immunosuppressive treatment of inflammatory cardiomyopathy patients

      • Andrea Frustaci, Cristina Chimenti

      Pages 257-264

   4. Antiviral interferon-β treatment in patients with chronic viral cardiomyopathy

      • Heinz-Peter Schultheiss, Michel Noutsias, Uwe Kühl

      Pages 265-278

Cardiomyopathy is one of the most frequent causes of heart failure. It is often associated with inadequate heart pumping or other heart function abnormalities. There are many different causes of the disease, e.g. other diseases, alcoholism, high blood pressure, viral infections; therefore many different kinds of cardiomyopathies exist, belonging to five main types of CM: Dilated CM, Hypertrophic CM, Restrictive CM, Right Ventricular CM, Nonclassifiable CM. This volume focuses on inflammatory CM, belonging to the Dilated Cardiomyopathies (DCMi). It covers epidemiology/prognosis, pathology, immunology, diagnosis and treatment strategies.

• antibody
• autoimmunity
• cytokine
• genetics
• heart
• immune system
• immunology
• infection
• infections
• inflammation
• interferon
• molecular genetics
• pathogenesis
• pathology
• viral infection
• infectious diseases

• Department of Cardiology and Pneumology, Charité—Universitätsmedizin Berlin Campus Benjamin Franklin, Berlin, Germany

  Heinz-Peter Schultheiss, Michel Noutsias

Cardiomyopathy is one of the most frequent causes of heart failure, and a leading entity of cardiac transplantation in the era of modern heart failure regimens. This volume focuses on major advances in inflammatory cardiomyopathy (DCMi) during the past 10 years. The book is divided up into the following sections: 1. Myocarditis and inflammatory cardiomyopathy – clinical management, epidemiology and prognosis; 2. Animal Models of myocarditis – autoimmunity and viral infection; therapeutic interventions; 3. Alterations of the immune system in human viral and inflammatory cardiomyopathy; 4. Diagnosis of inflammatory and viral cardiomyopathy; 5. Treatment strategies in inflammatory cardiomyopathy patients. An international group of authors discusses topics as the histological Dallas criteria for clinical diagnostics, emerging relevance of immunohistological detection of DCMi and detectability of viruses in EMBs, and epidemiology and standard clinical treatment of acute myocarditis and dilated cardiomyopathy patients. This volume serves as a valuable source for cardiologists and cardiovascular pathologists to update their knowledge on DCMi, a still enigmatic and fascinating cardiovascular disorder, which has made major steps from bench to bedside in the past decade.

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