The Immune Synapse as a Novel Target for Therapy

1. Front Matter

   Pages i-xii

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2. The immune synapse and T cell activation: regulation by chemokines

   • Emmanuel Donnadieu

   Pages 1-13

3. The induction of regulatory T cells by targeting the immune synapse

   • Luis Graca

   Pages 15-34

4. Infiltrating the immunological synapse: prospects for the use of altered peptide ligands for the treatment of immune pathology

   • Paul J. Fairchild

   Pages 35-47

5. Targeting CD4 for the induction of dominant tolerance

   • Herman Waldmann, Elizabeth Adams, Stephen Cobbold

   Pages 49-56

6. Anti-CD3: from T cell depletion to tolerance induction

   • Damien Bresson, Matthias von Herrath

   Pages 57-70

7. Immune modulation by CD40L blockade

   • Yuan Zhai, Jerzy W. Kupiec-Weglinski

   Pages 71-86

8. CTLA-4-immunoglobulin and indoleamine 2,3-dioxygenase in dominant tolerance

   • Francesca Fallarino, Carmine Vacca, Claudia Volpi, Maria T. Pallotta, Stefania Gizzi, Ursula Grohmann et al.

   Pages 87-106

9. Adhesion molecules as therapeutic targets

   • Mark R. Nicolls, Rasa Tamosiuniene

   Pages 107-128

10. E3 ubiquitin ligases and immune tolerance: Targeting the immune synapse from within?

    • Irene Puga, Fernando Macian

    Pages 129-146

11. FOXP3 biochemistry will lead to novel drug approaches for vaccines and diseases that lack suppressor T cells

    • Bin Li, Xiaomin Song, Arabinda Samanta, Kathryn Bembas, Amy Brown, Geng Zhang et al.

    Pages 147-154

12. Transforming growth factor-β: From its effect in T cell activation to a role in dominant tolerance

    • Ramireddy Bommireddy, Thomas Doetschman

    Pages 155-168

13. From mice to men: the challenges of developing tolerance-inducing biological drugs for the clinic

    • Wan-Fai Ng, John D. Isaacs

    Pages 169-185

14. Back Matter

    Pages 187-192

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It is now accepted that T cell activation by an antigen-presenting cell requires the organization of a supramolecular structure – the immune synapse. This structure, with different types of molecules spatially segregated, is involved in the delivery of quantitative and qualitative signals critical for T cell activation, and therefore in controlling the nature of the immune response. This volume discusses the progress in manipulating components of the immune synapse as a strategy to regulate the immune response in immune pathology, such as transplantation, autoimmunity and allergy. Donnadieu reviews the current knowledge on the molecular composition and organization of the immune synapse and how the formation of this structure can be modulated by chemokines. It is also known that the immune synapse formation is critical for the activation of naive T cells, as well as their functional polarization. The second chapter discusses the conversion of naive T cells into regulatory T cells (Treg) when components of the immune synapse are manipulated in such a way that the T cells receive suboptimal activation signals.

• Activation
• Antigen
• Monoclonal Antibodies
• T cell
• antibody
• autoimmunity
• biochemistry
• cell
• clinical trial
• drug
• immunity
• lead
• regulation
• research
• vaccine
• infectious diseases

• Unidade de Imunologia Celular Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal

  Luis Graca

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