Poxviruses

1. Front Matter

   Pages i-xx

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2. Genus Orthopoxvirus: Vaccinia virus

   • Geoffrey L. Smith

   Pages 1-45

3. Genus Orthopoxvirus: Variola virus

   • Inger K. Damon

   Pages 47-64

4. Genus Orthopoxvirus: Monkeypox virus

   • Sandra Essbauer, Hermann Meyer

   Pages 65-73

5. Genus Orthopoxvirus: Cowpox virus

   • Sandra Essbauer, Hermann Meyer

   Pages 75-88

6. Genus Molluscipoxvirus

   • Joachim J. Bugert

   Pages 89-112

7. Genus Yatapoxvirus

   • Geoffrey L. Smith

   Pages 113-125

8. Genus Parapoxvirus

   • Stephen B. Fleming, Andrew A. Mercer

   Pages 127-165

9. Genus Capripoxvirus

   • Adama Diallo, Gerrit J. Viljoen

   Pages 167-181

10. Genus Leporipoxvirus

    • John W. Barrett, Grant McFadden

    Pages 183-201

11. Genus Suipoxvirus

    • Gustavo A. Delhon, Edan R. Tulman, Claudio L. Afonso, Daniel L. Rock

    Pages 203-215

12. Genus Avipoxvirus

    • David B. Boyle

    Pages 217-251

13. Subfamily Entomopoxvirinae

    • Marie N. Becker, Richard W. Moyer

    Pages 253-271

14. Immunomodulation by poxviruses

    • Steven H. Nazarian, Grant McFadden

    Pages 273-296

15. Immunomodulation by inactivated Orf virus (ORFV) - therapeutic potential

    • Olaf Weber, Percy Knolle, Hans-Dieter Volk

    Pages 297-310

16. Recombinant poxvirus vaccines in biomedical research

    • Barbara S. Schnierle, Yasemin Suezer, Gerd Sutter

    Pages 311-327

17. Orthopoxvirus vaccines and vaccination

    • Lauren M. Handley, J. Paige Mackey, R. Mark Buller, Clifford J. Bellone

    Pages 329-353

18. Poxvirus diagnostics

    • Martin Pfeffer, Hermann Meyer

    Pages 355-373

19. Therapy of poxvirus infections

    • Robert Snoeck, Graciela Andrei, Erik De Clercq

    Pages 375-395

20. Environmental resistance, disinfection, and sterilization of poxviruses

    • Friedrich v. Rheinbaben, Jürgen Gebel, Martin Exner, Axel Schmidt

    Pages 397-405

The study of poxviruses has a long and distinguished history that includes Jenner’s founding work on smallpox vaccination. In the more than 200 years since that time we have seen the remarkable eradication of smallpox. It is difficult to overstate the significance of that achievement. It not only removed a disease that must rate as one of humankind’s greatest scourges, but also demonstrated the effectiveness of the general principle of vacci- tion in our battles against disease. This book begins with a review of smallpox and its causative agent, Variola virus. The vaccine used in the successful smallpox eradication c- paign, vaccinia virus, is reviewed in the following chapter that describes its origin and its use as a vaccine, as well as the current understanding of the molecular biology and pathogenesis of this virus. Vaccinia virus is the most intensively studied poxvirus and the descriptions of the biology of this virus are relevant to all vertebrate poxviruses. The eradication ofsmallpox has drawn attention to the potential threat posed by other orthopoxviruses that infect humans, particularly Monkeypox virus. A description of this virus is given in the third chapter. Jenner’s ori- nal vaccine is believed to have been Cowpox virus and this virus is reviewed in the chapter by Essbauer and Meyer. Additional chapters are devoted to each of the recognized genera of the vertebrate poxviruses and a f- ther chapter describes the subfamily of poxviruses infecting invertebrates. Together these provide a comprehensive review of the poxvirus family.

• diagnostics
• infection
• infections
• medical microbiology
• microbiology
• molecular biology
• vaccination
• vaccine
• virology
• virus

• Department of Microbiology, University of Otago, Dunedin, New Zealand

  Andrew A. Mercer

• Faculty of Medicine, University Witten/Herdecke, Witten, Germany

  Axel Schmidt

• BAYER HEALTHCARE AG, Product-related Research, Wuppertal, Germany

  Olaf Weber

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