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Erythropoietins and Erythropoiesis

Molecular, Cellular, Preclinical, and Clinical Biology

  • Book
  • © 2006

Overview

Editors:
  1. Graham Molineux

    1. Amgen Inc, Thousand Oaks, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Mary Ann Foote

    1. Amgen Inc, Thousand Oaks, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Steven G. Elliott

    1. Amgen Inc, Thousand Oaks, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Covers background and basic science as well as clinical uses of recombinant erythropoietins
  • Also of interest to clinicians in sports medicine glossary of terms and abbreviations
  • Unchanged second printing of the hardcover edition published in 2003
  • Includes supplementary material: sn.pub/extras

Part of the book series: Milestones in Drug Therapy (MDT)

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Table of contents (15 chapters)

  1. Front Matter

    Pages I-XI
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  2. Background and basic science

    1. Front Matter

      Pages 1-1
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    2. Erythropoiesis: an overview

      • Lyonel G. Israels, Esther D. Israels
      Pages 3-14

    3. Studies of erythropoiesis and the discovery and cloning of recombinant human erythropoietin

      • MaryAnn Foote
      Pages 15-23

    4. Structural basis for the signal transduction of erythropoietin

      • Timothy Osslund, Rashid Syed
      Pages 25-34

    5. Molecular biology of the erythropoietin receptor in hematopoietic and non-hematopoietic tissues

      • Christof Dame
      Pages 35-64

    6. Erythropoietin receptor signaling processes

      • Saghi Ghaffari, Lily Jun-shen Huang, Jing Zhang, Harvey F. Lodish
      Pages 65-85

    7. Clinical pharmacokinetic properties of rHuEPO: a review

      • Anne C. Heatherington
      Pages 87-112

    8. Biology of erythropoietin

      • Graham Molineux
      Pages 113-132

    9. Commercial production of recombinant erythropoietins

      • Alice S. Chuck, Rohini R. Deshpande, Adrian R. Distler, Shane A. Sander, James E. Seely
      Pages 133-150

  3. Clinical use of recombinant erythropoietins

    1. Front Matter

      Pages 151-151
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    2. Use of recombinant erythropoietins in the setting of renal disease

      • Iain C. Macdougall
      Pages 153-161

    3. Erythropoietic therapy in the practice of oncology

      • John Glaspy
      Pages 163-184

    4. Use of recombinant erythropoietins for the treatment of anemia of chronic disease

      • Robert T. Means Jr.
      Pages 185-196

    5. Use of erythropoietins in the surgical setting

      • Fred D. Cushner
      Pages 197-204

    6. Abuse of recombinant erythropoietins by athletes

      • Don H. Catlin, Caroline K. Hatton, Françoise Lasne
      Pages 205-227

    7. Antibodies to endogenous and recombinant erythropoietin

      • Patrick Mayeux, Nicole Casadevall
      Pages 229-239

    8. New molecules and formulations of recombinant human erythropoietin

      • Steven G. Elliott
      Pages 241-258

  4. Back Matter

    Pages 259-269
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Keywords

About this book

Research on, and interest in, red blood cell formation spans several centuries and was thought to have peaked in the 1980s with the cloning of the eryth- poietin (EPO) gene. In the years subsequent to the cloning of EPO and its expression as a recombinant protein, much was written about EPO. Although much has been learned and published, new, exciting data are becoming ava- able on almost a daily basis. Erythropoietins and Erythropoiesis: Molecular, Cellular, Preclinical, and Clinical Biology compiles both pertinent historical and very recent research on this molecule and its clinical utility. The book is divided into two sections: Background and Basic Science and Clinical Uses of Recombinant Erythropoietins. To begin, Israels and Israels describe the biology of red cells, the hierarchy of erythropoietic progenitor cells, their development to mature cells, and the effects of endogenous EPO on their development. Foote summarizes the historical interest in, and search for, an erythropoietic factor. Once EPO was identified,cloned,and expressed,the path was set for the study of other aspects of EPO biology both within e- thropoiesis and other cellular systems.

Editors and Affiliations

  • Amgen Inc, Thousand Oaks, USA

    Graham Molineux, Mary Ann Foote, Steven G. Elliott

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