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The NPY Family of Peptides in Immune Disorders, Inflammation, Angiogenesis, and Cancer

  • Book
  • © 2005

Overview

Editors:
  1. Zofia Zukowska

    1. Department of Physiology and Biophysics, Georgetown University Medical Center, Washington, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Giora Z. Feuerstein

    1. Wyeth Research, Collegeville, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Comprehensive two-volume overview of the NPY family of peptides
  • Insights into a promising field of inflammation research
  • Gives outlook on new strategies for treatment of cancer and vascular ischemic diseases
  • Includes supplementary material: sn.pub/extras

Part of the book series: Progress in Inflammation Research (PIR)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xv
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  2. Biology of the NPY family of peptides, their receptors and processing enzymes

    1. Evolutionary perspective on the NPY-PYY-PP peptides and their receptors

      • Dan Larhammar, Erik Salaneck
      Pages 3-28

    2. Function, distribution and molecular pharmacology of NPY-family receptors

      • Magnus M. Berglund, Philip A. Hipskind, Donald R. Gehlert
      Pages 29-62

    3. NPY processing in neuronal and non-neuronal tissues by proconvertases

      • Eric Grouzmann, Noureddine Brakch
      Pages 63-74

    4. Dipeptidyl-peptidase IV and aminopeptidase P: molecular switches of NPY/PYY receptor affinities

      • Rolf Mentlein
      Pages 75-84

  3. The NPY family of peptides in immune disorders and inflammation

    1. NPY, NPY receptors and DPPIV in innate immunity and autoimmune disorders

      • Sammy Bedoui, Stephan von Hörsten
      Pages 87-106

    2. NPY and phagocytic cell functions

      • Mónica De la Fuente, Sonia Medina
      Pages 107-122

    3. NPY in allergic and respiratory disorders

      • Basile N. Landis, Isabelle Plouin-Gaudon, Jean-Silvain Lacroix
      Pages 123-133

    4. NPY analgesia: moving from acute to chronic pain

      • Bradley K. Taylor
      Pages 135-148

  4. The NPY family of peptides and angiogenesis

    1. NPY as a mediator of neurogenic angiogenesis and revascularization of ischemic tissues

      • Edward W. Lee, Jason U. Tilan, Lydia E. Kuo, Zofia Zukowska
      Pages 151-166

    2. NPY-induced angiogenesis in retinopathy and wound healing

      • Meit Björndahl, Renhai Cao, Luxun Xue, Yihai Cao
      Pages 167-174

    3. NPY in vascular inflammation, remodeling and atherosclerosis

      • Lijun Li, Ken Abe, Edward W. Lee, Zofia Zukowska
      Pages 175-186

  5. The NPY family of peptides as growth factors in neurodegenerative diseases and tumor biology

    1. NPY as a pleiotropic growth factor

      • Joanna Kitlinska, Lydia E. Kuo, Jennifer Pons
      Pages 189-200

    2. NPY and Hippocampal Neurogenesis

      • William P. Gray, Helen E. Scharfman
      Pages 201-222

    3. NPY family of peptides in neural crest-derived tumors

      • Joanna B. Kitlinska
      Pages 223-236

    4. NPY family of peptides in endocrine, breast and prostate tumors

      • Massimiliano Ruscica, Elena Dozio, Marcella Motta, Paolo Magni
      Pages 237-248

  7. Back Matter

    Pages 255-258
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Keywords

About this book

Recent research indicates that the immune system and inflammatory reactions are governed and regulated by powerful neuronal mediators derived from the central and peripheral nervous system. The NPY family of peptides is a diverse group of neuropeptides that acts via multiple receptors, Y1-Y5, which are widespread not only in neurons but also in a variety of non-neural and immune cells. These peptides have been known as important regulators of many essential systems, such as blood pressure and cardiac function, food consumption and energy homeostasis. However, in recent years, they have also become recognized for their role as potent modulators of cell growth and immune functions with broad implications in chronic inflammatory diseases, cancer and angiogenesis.
In this book, experts in the field analyze recent evidence supporting the role of NPY family of peptides in regulation of the immune/inflammatory system with special reference to its medical and therapeutic implications.

Editors and Affiliations

  • Department of Physiology and Biophysics, Georgetown University Medical Center, Washington, USA

    Zofia Zukowska

  • Wyeth Research, Collegeville, USA

    Giora Z. Feuerstein

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