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Sodium Channels, Pain, and Analgesia

  • Book
  • © 2005

Overview

Editors:
  1. Michael J. Parnham

    1. PLIVA Research Institute Ltd., Zagreb, Croatia

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  2. Kevin Coward

    1. Department of Pharmacology, University of Oxford, Oxford, UK

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    You can also search for this editor in PubMed   Google Scholar

  3. Mark D. Baker

    1. Molecular Nociception Group Department of Biology Medawar Building, University College London, London, UK

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    You can also search for this editor in PubMed   Google Scholar

  • Written by well-known scientists in their respective fields
  • The Nav1.8 sodium channel is discussed
  • Provides current opinion and future direction
  • Includes supplementary material: sn.pub/extras

Part of the book series: Progress in Inflammation Research (PIR)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-x
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  2. Voltage-gated sodium channels and pain associated with nerve injury and neuropathies

    • Joel A. Black, Bryan C. Hains, Sulayman D. Dib-Hajj, Stephen G. Waxman
    Pages 1-21

  3. Current approaches for the discovery of novel NaV channel inhibitors for the treatment of brain disorders

    • Jeffrey J. Clare
    Pages 23-62

  4. Voltage-gated sodium channels and visceral pain

    • Jennifer M.A Laird, Fernando Cervero, Jennifer M.A Laird
    Pages 63-70

  5. The functional interaction of accessory proteins and voltage-gated sodium channels

    • Kenji Okuse, Mark D. Baker
    Pages 71-83

  6. Sodium channels and nociceptive nerve endings

    • James A. Brock
    Pages 85-105

  7. Signalling cascades that modulate the activity of sodium channels in sensory neurons

    • Grant D. Nicol
    Pages 107-121

  8. NaV1.8 as a drug target for pain

    • Lodewijk V. Dekker, David Cronk
    Pages 123-143

  9. Role of voltage-gated sodium channels in oral and craniofacial pain

    • Michael S. Gold
    Pages 145-164

  10. Sodium channel gating and drug blockade

    • Andreas Scholz
    Pages 165-180

  11. Future directions in sodium channel research

    • John N. Wood
    Pages 181-193

  12. Back Matter

    Pages 195-199
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Keywords

About this book

Sodium channels confer excitability on neurons in nociceptive pathways and exhibit neuronal tissue specific and injury regulated expression. This volume provides recent insights into the control of expression, functioning and membrane trafficking of nervous system sodium channels and reviews why sodium channel sub-types are potentially important drug targets in the treatment of pain. The roles of sodium channels in dental and visceral pain are also addressed. The emerging role of sodium channel Nav1.3 in neuropathic states is another important theme.

Authors from the pharmaceutical industry discuss pharmacological approaches to the drug targeting of sodium channels, and in particular Nav1.8, exclusively expressed in nociceptive neurons. The final chapter highlights the functional diversity of sodium channels in part provided by post-transcriptional processing and the insights into sodium channel function that are being provided by tissue specific and inducible gene knock-out technology.

Editors and Affiliations

  • PLIVA Research Institute Ltd., Zagreb, Croatia

    Michael J. Parnham

  • Department of Pharmacology, University of Oxford, Oxford, UK

    Kevin Coward

  • Molecular Nociception Group Department of Biology Medawar Building, University College London, London, UK

    Mark D. Baker

Bibliographic Information

  • Book Title: Sodium Channels, Pain, and Analgesia

  • Editors: Michael J. Parnham, Kevin Coward, Mark D. Baker

  • Series Title: Progress in Inflammation Research

  • DOI: https://doi.org/10.1007/3-7643-7411-X

  • Publisher: Birkhäuser Basel

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Birkhäuser Basel 2005

  • Hardcover ISBN: 978-3-7643-7062-6Published: 19 July 2005

  • eBook ISBN: 978-3-7643-7411-2Published: 17 January 2006

  • Series ISSN: 1422-7746

  • Series E-ISSN: 2296-4525

  • Edition Number: 1

  • Number of Pages: X, 202

  • Topics: Pain Medicine, Neurosciences, Pharmacology/Toxicology, Cell Biology

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