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Mechanisms of Secondary Brain Damage in Cerebral Ischemia and Trauma

  • Conference proceedings
  • © 1996

Overview

Editors:
  1. Alexander Baethmann

    1. Institut für Chirurgische Forschung, Klinikum Grosshadern, Ludwig-Maximilians-Universität, München, Federal Republic of Germany

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  2. Oliver S. Kempski

    1. Institut für Neurochirurgische Pathophysiologie, Johannes-Gutenberg-Universität, Mainz, Federal Republic of Germany

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  3. Nikolaus Plesnila

    1. Institut für Chirurgische Forschung, Klinikum Grosshadern, Ludwig-Maximilians-Universität, München, Federal Republic of Germany

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  4. Frank Staub

    1. Klinik für Neurochirurgie, Universität zu Köln, Köln, Federal Republic of Germany

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Part of the book series: Acta Neurochirurgica Supplement (NEUROCHIRURGICA, volume 66)

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Table of contents (21 papers)

  1. Front Matter

    Pages I-VIII
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  2. Molecular and Cell Biological Mechanisms — Inflammatory Processes

    1. Molecular Correlates of Delayed Neuronal Death Following Transient Forebrain Ischemia in the Rat

      • Christoph Wiessner, P. Vogel, T. Neumann-Haefelin, K.-A. Hossmann
      Pages 1-7

    2. Molecular Mechanisms of Acidosis-Mediated Damage

      • Bo. K. Siesjö, K. I. Katsura, T. Kristián, P.-A. Li, P. Siesjö
      Pages 8-14

    3. Is Calcium Accumulation Post-Injury an Indicator of Cell Damage?

      • R. Linde, H. Laursen, A. J. Hansen
      Pages 15-20

    4. Apoptosis in Focal Cerebral Ischemia

      • Michael Chopp, Y. Li
      Pages 21-26

    5. Significance of the Inflammatory Response in Brain Ischemia

      • John M. Hallenbeck
      Pages 27-31

    6. Leukocytes, Macrophages and Secondary Brain Damage Following Cerebral Ischemia

      • Minoru Tomita, Y. Fukuuchi
      Pages 32-39

    7. Inflammation of the Brain after Ischemia

      • Kyuya Kogure, Y. Yamasaki, Y. Matsuo, H. Kato, H. Onodera
      Pages 40-43

  3. Novel Findings on Mechanisms and Treatment of Cerebral Ischemia

    1. Three-Dimensional Metabolic and Hemodynamic Imaging of the Normal and Ischemic Rat Brain

      • Myron D. Ginsberg, T. Back, W. Zhao
      Pages 44-49

    2. Origins of Glutamate Release in Ischaemia

      • T. P. Obrenovitch
      Pages 50-55

    3. Swelling, Intracellular Acidosis, and Damage of Glial Cells

      • Frank Staub, A. Winkler, J. Haberstok, N. Plesnila, J. Peters, R. C. C. Chang et al.
      Pages 56-62

    4. Environmental Influence on Outcome After Experimental Brain Infarction

      • Barbro Johansson
      Pages 63-67

    5. Fetal Neocortical Grafts Placed in Brain Infarcts Do Not Improve Paw-Reaching Deficits in Adult Spontaneously Hypertensive Rats

      • Martin Grabowski, B. B. Johansson, P. Brundin
      Pages 68-72

    6. Extended Studies on the Effect of Glutamate Antagonists on Ischemic CA-1 Damage

      • N. H. Diemer, T. Balchen, T. Bruhn, T. Christensen, I. Vanicky, M. Nielsen et al.
      Pages 73-75

    7. Thrombolysis in Acute Ischemic Stroke

      • Cesare Fieschi, C. Cavalletti, D. Toni, M. Fiorelli, M. L. Sacchetti, M. De Michele et al.
      Pages 76-80

  4. Recent Observations on Mechanisms, Regeneration, and Treatment in Head Injury

    1. Traumatically Induced Axonal Damage: Evidence for Enduring Changes in Axolemmal Permeability with Associated Cytoskeletal Change

      • John T. Povlishock, E. H. Pettus
      Pages 81-86

    2. Expression of Microglial Markers in the Human CNS After Closed Head Injury

      • S. Engel, H. D. Wehner, R. Meyermann
      Pages 87-95

    3. Altered β-APP Metabolism After Head Injury and its Relationship to the Aetiology of Alzheimer’s Disease

      • D. I. Graham, S. M. Gentleman, J. A. R. Nicoll, M. C. Royston, J. E. McKenzie, G. W. Roberts et al.
      Pages 96-102

    4. Principles of Neuronal Regeneration

      • Georg W. Kreutzberg
      Pages 103-106

    5. Neuroprotective Efficacy of Microvascularly-Localized Versus Brain-Penetrating Antioxidants

      • Edward D. Hall, P. K. Andrus, S. L. Smith, J. A. Oostveen, H. M. Scherch, B. S. Lutzke et al.
      Pages 107-113
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Keywords

About this book

The publication of the Vth International Symposium 1995 on "Mechanisms of Secondary Brain Damage" in Mauls/ltaly is a collection of focused reviews reaching from novel molecular- and cell biological findings to aspects of clinical management in head injury and cerebral ischemia. A specific purpose of these series of meetings introduced in 1984 is for an exchange on problems of mutual interest by international high ranking experts from the basic sciences and related clinical disciplines, such as intensive care medicine, neurology, or neurosurgery. The present volume covers three major areas: (a) Molecular and cell biological mechanisms including inflammation (b) Novel findings on mechanisms and treatment in cerebral ischemia (c) Secondary processes in head injury, regeneration and treatment Molecular-and cell biology is currently attracting attention towards activation of genomic processes associated with the demise of cells referred to as "programmed cell death" and "apoptosis" which, actually, might be distinguished from each other. Thus, the phenomenon of delayed neuronal death in selectively vulnerable brain areas following brief interruption of blood flow is scrutinized as to the contribution of the activation of suicide genes. The physiological role of such a response, among others, is removal of surplus neurons during ontogenesis of the brain. Yet, evidence is accumulating that similar mechanisms playa role in cerebral ischemia, probably also trauma, where nerve-and other cells demonstrate features of apoptosis. Observations on protection of neurons by administration of protein synthesis inhibitors in cerebral ischemia provide more direct support.

Editors and Affiliations

  • Institut für Chirurgische Forschung, Klinikum Grosshadern, Ludwig-Maximilians-Universität, München, Federal Republic of Germany

    Alexander Baethmann, Nikolaus Plesnila

  • Institut für Neurochirurgische Pathophysiologie, Johannes-Gutenberg-Universität, Mainz, Federal Republic of Germany

    Oliver S. Kempski

  • Klinik für Neurochirurgie, Universität zu Köln, Köln, Federal Republic of Germany

    Frank Staub

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