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Parkinson’s Disease. From Clinical Aspects to Molecular Basis

  • Conference proceedings
  • © 1991

Overview

Editors:
  1. Toshiharu Nagatsu

    1. Department of Neurochemistry, Fujita Health University, Aichi, Japan

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  2. Hirotaro Narabayashi

    1. Neurological Clinic, Tokyo, Japan

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    You can also search for this editor in PubMed   Google Scholar

  3. Mitsuo Yoshida

    1. Department of Neurology, Jichi Medical School, Tochigi-ken, Japan

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Key Topics in Brain Research (KEYTOPICS)

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Table of contents (20 papers)

  1. Front Matter

    Pages I-VIII
    Download chapter PDF

  2. Tyrosine hydroxylase in relation to Parkinson’s disease: a historical overview and future prospect

    • T. Nagatsu
    Pages 1-11

  3. Discovery of dopamine deficiency and the possibility of dopa therapy in Parkinsonism

    • T. Nakajima
    Pages 13-17

  4. Genes of human catecholamine-synthesizing enzymes

    • T. Nagatsu, N. Kaneda, K. Kobayashi, H. Ichinose, T. Sasaoka, A. Ishii et al.
    Pages 19-38

  5. Receptor alterations in Parkinson’s disease

    • N. Ogawa, M. Asanuma
    Pages 39-51

  6. Second messengers in Parkinson’s disease

    • N. Nishino, N. Kitamura, T. Hashimoto, O. Komure, C. Tanaka
    Pages 53-59

  7. Mitochondrial energy crisis as a mechanism for nigral cell death

    • Y. Mizuno
    Pages 61-72

  8. Tetrahydroisoquinoline and its derivatives: the occurrence and the metabolism in the brain, and the effects on catecholamine metabolism

    • M. Naoi, T. Niwa, M. Yoshida, T. Nagatsu
    Pages 73-84

  9. Can tetrahydroisoquinoline (TIQ) or N-methyl-TIQ produce parkinsonism?

    • M. Yoshida, M. Ogawa, T. Nagatsu
    Pages 85-94

  10. Relationship between TIQs and Parkinson’s disease

    • S. Ohta, M. Kohno, Y. Makino, O. Tachikawa, Y. Tasaki, K. Kikuchi et al.
    Pages 95-101

  11. Sparteine oxidation in patients with early- and late-onset of Parkinson’s disease

    • K. Chiba, H. Imai, H. Yoshino, J. Kato, T. Ishizaki, H. Narabayashi
    Pages 103-109

  12. Association of Xba I allele (Xba I 44kb) of the human cytochrome P-450dbI (CYP2D6) gene in Japanese patients with idiopathic Parkinson’s disease

    • I. Kondo, I. Kanazawa
    Pages 111-117

  13. Immunological aspects of neural transplantation

    • S. Kohsaka
    Pages 119-127

  14. Epidemiology of Parkinson’s disease-interplaying genes and environmental factors

    • K. Kondo
    Pages 129-138

  15. Topics of special interest in research of Parkinson’s disease

    • H. Narabayashi
    Pages 139-142

  16. Importance of juvenile parkinsonism in elucidating the pathogenesis of Parkinson’s disease

    • M. Yokochi
    Pages 143-156

  17. Dopa-unresponsive pure akinesia or freezing

    • H. Imai
    Pages 157-166

  18. Hereditary progressive dystonia with marked diurnal fluctuation

    • M. Segawa, Y. Nomura
    Pages 167-177

  19. Positron emission tomographic study in Parkinson’s disease—rigid vs tremor type

    • C. Ohye
    Pages 179-186

  20. Role of stereotaxic surgery in treatment of Parkinson’s disease

    • H. Narabayashi
    Pages 187-199
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Keywords

About this book

This b00k reviews the recent advances in the research on Parkinson's disease. It contains review articles from basic to clinical researches including the historical introduction and the molecular biological approach to Parkinson's disease. Parkinson's disease is the most representative, age-related neurodegenerative disease. It is clinically characterized by movement disorders such as muscle rigidity, akinesia and tremor. The elucidation of its biochemical and molecular mechanisms has rapidly been progressing and is expected to contribute to the understanding of normal brain aging in general. This project is supported by a Grant-in-Aid for Scientific Research on Priority Areas, "Molecular Biology of the Motor System", Ministry of Education, Science and Culture, Japan, for 3 years from 1987 to 1989. We are grateful for the support. These reviews are a part of the works which have been supported by this Grant-in-Aid. The characteristics of this research project on Parkinson's disease are interdisciplinary approach from basic, molecular biology to clinical medicine, and the molecular biological approach is expected to be the most promising for the elucidation of the pathogenesis. The collaboration and discussion between basic and clinical researchers in this Priority Area Project has been efficient and productive. We hope that this book can mark another new milestone in the studies on Park,oson's disease and in neuroscience. We are very grateful to Nippon Schering for their generous support for the publication of this book. Last but not least, we thank Springer-Verlag Wien New York for the excellent production of this book and the excellent cooperation.

Editors and Affiliations

  • Department of Neurochemistry, Fujita Health University, Aichi, Japan

    Toshiharu Nagatsu

  • Neurological Clinic, Tokyo, Japan

    Hirotaro Narabayashi

  • Department of Neurology, Jichi Medical School, Tochigi-ken, Japan

    Mitsuo Yoshida

Bibliographic Information

  • Book Title: Parkinson’s Disease. From Clinical Aspects to Molecular Basis

  • Editors: Toshiharu Nagatsu, Hirotaro Narabayashi, Mitsuo Yoshida

  • Series Title: Key Topics in Brain Research

  • DOI: https://doi.org/10.1007/978-3-7091-9146-0

  • Publisher: Springer Vienna

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag/Wien 1991

  • Softcover ISBN: 978-3-211-82272-2Published: 06 November 1991

  • eBook ISBN: 978-3-7091-9146-0Published: 06 December 2012

  • Series ISSN: 0934-1420

  • Edition Number: 1

  • Number of Pages: VIII, 220

  • Number of Illustrations: 54 b/w illustrations

  • Topics: Neurology, Neurosciences, Pharmacology/Toxicology

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