The CNS Control of Glucose Metabolism

1. Front Matter

   Pages I-VIII

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2. Introduction

   • Ernst Heinrich Grote

   Pages 1-2

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3. The Regulation of Glucose Metabolism

   • Ernst Heinrich Grote

   Pages 3-35

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4. Methods Employed

   • Ernst Heinrich Grote

   Pages 36-44

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5. Results

   • Ernst Heinrich Grote

   Pages 45-132

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6. Consideration of the Results and Discussion

   • Ernst Heinrich Grote

   Pages 133-141

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7. Summary

   • Ernst Heinrich Grote

   Pages 142-145

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8. Back Matter

   Pages 146-160

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In the clinic at Giessen during the last few years there has been an extensive programme of research into the various aspects of lesions of the diencephalon and brain stem and the associated autonomic and metabolic disturbances. As a continuation of this research programme Ernst Grote has investigated the central neuronal and hormonal factors acting on the peripheral regulation of glucose metabolism and their diverse inter-relationships. This research was made possible not only by the availability of well-documented clinical and experi­ mental material with primary and secondary lesions of the hypo­ thalamus and brain stem, but also by the advances in clinical endo­ crinology and the development of radio-immuno-assays. By continuous systematic investigation of the basic values and their reaction to stress-tests, as well as to trauma and operation, he has elucidated the basic facts of the central and peripheral mechanisms which are concerned in the regulation of glucose, and also their disturbances. Of particular significance are his descriptions and interpretations of the characteristic hypothalamic syndromes, as combinations of hyperglycaemia, hyperinsulinaemia and hyperglucagonaemia; dif­ ferent syndromes are produced by lesions at various levels of the brain stem and in central brain death. From this starting point it was possible to develop a rational treatment of this hormonal dys­ regulation by means of somatostatin.

• Hirnerkrankung
• Hormonale Regulation
• Kohlenhydratstoffwechsel
• Metabolism
• Zentralnervöse Regulation
• brain
• nervous system
• trauma

• University Clinics Giessen, Federal Republic of Germany

  Ernst Heinrich Grote

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