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Drug Receptor Interactions in Antimicrobial Chemotherapy

Symposium, Vienna, September 4–6, 1974

  • Conference proceedings
  • © 1975

Overview

Editors:
  1. Jürgen Drews

    1. Sandoz Forschungsinstitut Gesellschaft m. b. H., Vienna, Austria

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  2. E. Hahn

    1. Walter Reed Army Medical Center, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Topics in Infectious Diseases (TIDIS, volume 1)

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Table of contents (20 papers)

  1. Front Matter

    Pages I-VIII
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  3. DNA as a Drug-Receptor

    1. Front Matter

      Pages 57-57
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    2. The Ecological Significance of R Factor Activity

      • E. S. Anderson
      Pages 59-76

    3. Structural Constraints in the Binding of Drugs to DNA

      • Michael Waring
      Pages 77-90

    4. Molecular Aspects of the Biosynthesis of R Factor DNA

      • Royston Clowes, Toshihiko Arai, Gerry Anderson
      Pages 91-98

    5. Elimination of Plasmidic Determinants by DNA-Complexing Compounds

      • Fred E. Hahn, Jennie Ciak
      Pages 99-113

  4. Ribosomes as Drug-Receptors

    1. Front Matter

      Pages 115-115
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    2. Antibiotic Receptor-Sites in Escherichia coli Ribosomes

      • Georg Stöffler, Gilbert W. Tischendorf
      Pages 117-143

    3. Altered Methylation of Ribosomal RNA in Erythromycin-Resistant Staphylococcus Aureus

      • Bernard Weisblum
      Pages 145-155

    4. Binding of Tetracyclines and Other Antibiotics to Ribosomes

      • H. Kersten
      Pages 157-165

    5. Ribosomal Effects of Thiostrepton and Related Antibiotics

      • Eric Cundliffe, Janet E. Beven, Peter D. Dixon
      Pages 167-177

    6. Studies on Active Sites of Ribosomes with Haloacetylated Antibiotic Analogs

      • O. Pongs, R. Bald, V. A. Erdmann, E. Reinwald
      Pages 179-190

  5. The Mode of Action of Chloramphenicol

    1. Front Matter

      Pages 191-191
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    2. Antibiotic Action on the Ribosomal Peptidyl Transferase Centre

      • D. Vazquez, M. Barbacid, R. Fernandez-Muñoz
      Pages 193-216

    3. Experiments on the Binding Sites and the Action of Some Antibiotics which Inhibit Ribosomal Functions

      • R. Werner, A. Kollak, D. Nierhaus, G. Schreiner, K. H. Nierhaus
      Pages 217-234
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Keywords

About this book

The concept of chemotherapy as originated by Paul Ehrlich is based on the premise that antiparasitic drugs must have two properties: they must first bind to specific structures of the parasite which Ehrlich called chemoreceptors. Subsequent to their attachment to the chemoreceptor and by virtue of this binding they must possess the capacity to kill the parasite. Since the host which is to be cured of an invading parasite also contains a large number of chemoreceptors, that have the potential to bind toxic compounds, the task of the chemo­ therapist is to identify chemoreceptors of the parasite which are . not represented in the host and to design drugs which bind selectively to them~ In this context, Ehrlich called· for "the complete and exhaustive knowledge of all the different chemoreceptors of a certain parasite" as a "sine qua non for success in chemotherapy". Paradoxically and in spite of the fact that chemotherapy has become a very advanced and successful therapeutic discipline,few of its tri­ umphs have been achieved by following Ehrlich's original precepts. On the contrary, in the overwhelming majority of cases, effective drugs have been discovered without any knowledge of their chemoreceptors, and these drugs themselves have conversely been used as tools to study the nature of the chemoreceptors involved. In other words: chemother­ apy, notably antibacterial chemotherapy, has been successful without ever living up to the fundamental standards put forward by Paul Ehr­ lich.

Editors and Affiliations

  • Sandoz Forschungsinstitut Gesellschaft m. b. H., Vienna, Austria

    Jürgen Drews

  • Walter Reed Army Medical Center, USA

    E. Hahn

Bibliographic Information

  • Book Title: Drug Receptor Interactions in Antimicrobial Chemotherapy

  • Book Subtitle: Symposium, Vienna, September 4–6, 1974

  • Editors: Jürgen Drews, E. Hahn

  • Series Title: Topics in Infectious Diseases

  • DOI: https://doi.org/10.1007/978-3-7091-8405-9

  • Publisher: Springer Vienna

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag/Wien 1975

  • Softcover ISBN: 978-3-7091-8407-3Published: 07 January 2012

  • eBook ISBN: 978-3-7091-8405-9Published: 06 December 2012

  • Series ISSN: 0171-2160

  • Edition Number: 1

  • Number of Pages: VIII, 314

  • Topics: Medicine/Public Health, general

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