Recombinant Human Erythropoietin (rhEPO) in Clinical Oncology

1. Front Matter

   Pages i-ix

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2. Biology of erythropoietin

   • Catherine Lacombe, P. Mayeux

   Pages 1-21

3. Classification and characterization of anemia in cancer

   • M. R. Nowrousian

   Pages 23-38

4. Pathophysiology of cancer-related anemia

   • M. R. Nowrousian

   Pages 39-62

5. Prevalence, pathophysiology, predictive factors, and prognostic significance of anemia in cancer chemotherapy

   • M. R. Nowrousian

   Pages 63-100

6. Incidence and impact of anemia in radiation oncology

   • Jürgen Dunst, M. Molls

   Pages 101-115

7. Relationship between anemia and tumor hypoxia

   • Jürgen Dunst, M. Molls

   Pages 117-125

8. Tumor hypoxia and therapeutic resistance

   • Peter Vaupel, Michael Höckel

   Pages 127-146

9. Impact of anemia on organ functions

   • M. R. Nowrousian

   Pages 147-172

10. Relationship between anemia, fatigue, and quality of life in cancer patients

    • Yvonne Brandberg

    Pages 173-184

11. Red blood cell transfusion, risks and limitations

    • Francesco Mercuriali, G. Inghilleri

    Pages 185-201

12. Pharmacology, pharmacokinetics and safety of recombinant human erythropoietin (rhEPO)

    • Wolfgang Jelkmann

    Pages 203-221

13. Recombinant human erythropoietin (rhEPO) in anemia associated with multiple myeloma and non-Hodgkin’s lymphoma

    • Anders Österborg

    Pages 223-234

14. Use of recombinant human erythropoietin in the treatment of myelodysplastic syndromes

    • Mario Cazzola

    Pages 235-239

15. rhEPO in anemia associated with solid tumors and chemotherapy

    • M. R. Nowrousian

    Pages 241-262

16. Predictive factors for response of anemia to recombinant human erythropoietin

    • Yves Beguin

    Pages 263-286

17. rhEPO in hematopoietic stem cell mobilization, transplantation and in-vitro expansion

    • Sven Klaesson

    Pages 287-299

18. Clinical trials using rhEPO in radiation oncology

    • Michael Henke

    Pages 301-311

19. rhEPO in pediatric oncology

    • Carlo Cappelli, G. Ragni, A. Clerico

    Pages 313-323

20. rHuEPO in surgical oncology

    • Francesco Mercuriali, G. Inghilleri

    Pages 325-346

Anemia is a frequent complication of cancer and its treatment. A number of clinical studies shows that the impact of anemia is much greater than previously thought. Beyond clinical symptoms, anemia significantly impairs physical and metabolic functions as well as patients' activity, well-being and quality of life. Life expectancy is also affected. In this book, written by a group of outstanding international experts, the current knowledge on anemia in cancer and its treatment with rhEPO is presented and future developments are discussed. Based on a broad spectrum of topics, the book describes the scientific and clinical aspects of anemia in various fields of oncology and gives diagnostic and therapeutic recommendations on when and how to use rhEPO. The book will serve as an authentic and essential source of information for radiotherapists, oncologists, hematologists, internists, pediatricians, surgeons, specialists in transfusion or laboratory medicine and pharmacologists.

• Fatigue
• Tumor
• anemia
• chemotherapy
• classification
• hemoglobin
• pathophysiology
• physiology
• radiation oncology
• therapeutic resistance
• transplantation
• Radiaton Oncology

• Innere Klinik und Poliklinik (Tumorforschung), Westdeutsches Tumorzentrum, Essen, Universitätsklinikum, Essen, Deutschland

  M. R. Nowrousian

Policies and ethics