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Advances in Research on Neurodegeneration

Volume 7

  • Conference proceedings
  • © 2000

Overview

Editors:
  1. Y. Mizuno

    1. Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan

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  2. D. B. Calne

    1. Neurodegenerative Disorders Centre, Faculty of Medicine, University Hospital, Vancouver, Canada

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  3. R. Horowski

    1. Clinical Research, Schering AG, Berlin, Federal Republic of Germany

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  4. W. Poewe

    1. Department of Neurology, University of Innsbruck, Austria

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  5. P. Riederer

    1. Department of Psychiatry, University of Würzburg, Federal Republic of Germany

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  6. M. B. H. Youdim

    1. Rappaport Family Institute for Research in the Medical Sciences, Haifa, Israel

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Table of contents (17 papers)

  1. Front Matter

    Pages I-VII
    Download chapter PDF

  2. Huntington disease: new insights on the role of huntingtin cleavage

    • C. L. Wellington, B. R. Leavitt, M. R. Hayden
    Pages 1-17

  3. PARKIN as a pathogenic gene for autosomal recessive juvenile parkinsonism

    • N. Shimizu, S. Asakawa, S. Minoshima, T. Kitada, N. Hattori, H. Matsumine et al.
    Pages 19-30

  4. Autosomal-dominantly inherited forms of Parkinson’s disease

    • T. Gasser
    Pages 31-40

  5. Role of anti-apoptotic Bcl-2 protein in spinal muscular atrophy

    • Y. Tsujimoto
    Pages 41-52

  6. Subcellular localization of α-synuclein in primary neuronal cultures: effect of missense mutations

    • P. J. McLean, S. Ribich, B. T. Hyman
    Pages 53-63

  7. Roles of Aβ and carboxyl terminal peptide fragments of amyloid precursor protein in Alzheimer disease

    • Y.-H. Suh, H.-S. Kim, J. P. Lee, C. H. Park, S.-J. Jeong, S.-S. Kim et al.
    Pages 65-82

  8. Iron chelating, antioxidant and cytoprotective properties of dopamine receptor agonist; apomorphine

    • M. B. H. Youdim, M. Gassen, A. Gross, S. Mandel, E. Grünblatt
    Pages 83-96

  9. The motor circuit of the human basal ganglia reconsidered

    • P. Foley, P. Riederer
    Pages 97-110

  10. Involvement of endogenous N-methyl(R)salsolinol in Parkinson’s disease: induction of apoptosis and protection by (-)deprenyl

    • M. Naoi, W. Maruyama, T. Takahashi, Y. Akao, Y. Nakagawa
    Pages 111-121

  11. The myelin oligodendrocyte glycoprotein (MOG): a model for antibody-mediated demyelination in experimental autoimmune encephalomyelitis and multiple sclerosis

    • A. Stefferl, U. Brehm, C. Linington
    Pages 123-133

  12. Role of caspase-1 subfamily in cytotoxic cytokine-induced oligodendrocyte cell death

    • S. Hisahara, R. Takano, S. Shoji, H. Okano, M. Miura
    Pages 135-142

  13. Cytokines in Parkinson’s disease

    • T. Nagatsu, M. Mogi, H. Ichinose, A. Togari
    Pages 143-151

  14. Apoptosis as a general cell death pathway in neurodegenerative diseases

    • D. Offen, H. Elkon, E. Melamed
    Pages 153-166

  15. Dentatorubral-pallidoluysian atrophy (DRPLA)

    • S. Tsuji
    Pages 167-180

  16. Gene therapy of Parkinson’s disease using Adeno-Associated Virus (AAV) vectors

    • K. Ozawa, D.-S. Fan, Y. Shen, S. Muramatsu, K. Fujimoto, K. Ikeguchi et al.
    Pages 181-191

  17. Mechanisms of tissue injury in multiple sclerosis: opportunities for neuroprotective therapy

    • S. Pouly, J. P. Antel, U. Ladiwala, J. Nalbantoglu, B. Becher
    Pages 193-203

  18. Optic-spinal form of multiple sclerosis and immune-mediated myelopathy in Japan

    • K. Fujihara, I. Nakashima, Y. Itoyama
    Pages 205-214
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Keywords

About this book

We organized the Seventh International Winter Conference on Neurodegeneration and Neuroinflammation in a small town of Karuizawa in Nagano Prefecture in Japan on January 20 to 22, 1999. Karuizawa is a nice summer as well as winter resort close to the place for winter Olympic game in the year of 1998. Over 40 scientists gathered together and made hot discussion. Neurodegeneration and neuroinflammation are two major and important neurologic disorders, in which satisfactory neuroprotective and neurorestorative treatment is not available yet. For this purpose, understanding of molecular mechanisms of neuronal cell death in these two disorders is imperative. Recently, pathologic processes common to these two groups of disorders have been identified such as the involvement of inflammatory changes, microglia, cytokines, and apoptosis. We intended to involve scientists working in these two major fields together to participate in hot and fruitful discussion for the understanding of neuronal death and for developing newer methods of treatment. The science is progressing so rapidly today and we are working in a very narrow specialized area. Sometimes, we are ignorant about important discoveries in other fields. This conference was a nice opportunity for scien­ tists working different areas to meet together and to exchange their experi­ ence. This volume is the proceedings of this Winter Conference.

Editors and Affiliations

  • Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan

    Y. Mizuno

  • Neurodegenerative Disorders Centre, Faculty of Medicine, University Hospital, Vancouver, Canada

    D. B. Calne

  • Clinical Research, Schering AG, Berlin, Federal Republic of Germany

    R. Horowski

  • Department of Neurology, University of Innsbruck, Austria

    W. Poewe

  • Department of Psychiatry, University of Würzburg, Federal Republic of Germany

    P. Riederer

  • Rappaport Family Institute for Research in the Medical Sciences, Haifa, Israel

    M. B. H. Youdim

Bibliographic Information

  • Book Title: Advances in Research on Neurodegeneration

  • Book Subtitle: Volume 7

  • Editors: Y. Mizuno, D. B. Calne, R. Horowski, W. Poewe, P. Riederer, M. B. H. Youdim

  • DOI: https://doi.org/10.1007/978-3-7091-6284-2

  • Publisher: Springer Vienna

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Wien 2000

  • Hardcover ISBN: 978-3-211-83485-5Published: 06 November 2000

  • eBook ISBN: 978-3-7091-6284-2Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: VII, 216

  • Additional Information: Special edition of Journal of Neural Transmission, Suppl. 58

  • Topics: Neurology, Pathology, Pharmacology/Toxicology, Neurosciences, Immunology, Biochemistry, general

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