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MAO - The Mother of all Amine Oxidases

  • Conference proceedings
  • © 1998

Overview

Editors:
  1. J. P. M. Finberg

    1. Department of Pharmacology, The Bruce Rappaport Faculty of Medicine, Technion — Israel Institute of Technology, Haifa, Israel

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  2. M. B. H. Youdim

    1. Department of Pharmacology, The Bruce Rappaport Faculty of Medicine, Technion — Israel Institute of Technology, Haifa, Israel

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  3. P. Riederer

    1. Clinical Neurochemistry, Department of Psychiatry, University of Würzburg, Federal Republic of Germany

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  4. K. F. Tipton

    1. Biochemistry Department, Trinity College, Dublin, Ireland

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  • Recent advances in amine oxidases, especially MAO
  • Possibility of a genetic basis for psychiatric disorders based on MAO

Part of the book series: Journal of Neural Transmission. Supplementa (NEURAL SUPPL, volume 52)

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Table of contents (38 papers)

  1. Front Matter

    Pages I-XIX
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  2. Determination of regions important for Monoamine Oxidase (MAO) A and B substrate and inhibitor selectivities

    • J. C. Shih, K. Chen, R. M. Geha
    Pages 1-8

  3. Monoamine oxidase A deficiency: Biogenic amine metabolites in random urine samples

    • N. G. G. M. Abeling, A. H. van Gennip, A. G. van Cruchten, H. Overmars, H. G. Brunner
    Pages 9-15

  4. Relationship between monoamine oxidase (MAO) A specific activity and proportion of human skin fibroblasts which express the enzyme in culture

    • R. M. Denney
    Pages 17-27

  5. Are MAO-A deficiency states in the general population and in putative high-risk populations highly uncommon?

    • D. L. Murphy, K. Sims, G. Eisenhofer, B. D. Greenberg, T. George, F. Berlin et al.
    Pages 29-38

  6. Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline)

    • D. L. Murphy, F. Karoum, D. Pickar, R. M. Cohen, S. Lipper, A. M. Mellow et al.
    Pages 39-48

  7. Experience with tranylcypromine in early Parkinson’s disease

    • S. Fahn, S. Chouinard
    Pages 49-61

  8. Deprenyl monotherapy improves visuo-motor control in early parkinsonism

    • S. Hocherman, G. Levin, N. Giladi, M. B. H. Youdim
    Pages 63-69

  9. Endogenous monoamine oxidase A inhibitory activity (tribulin), measured in saliva, is related to cardiovascular reactivity in normal individuals

    • A. Clow, A. Doyle, F. Hucklebridge, D. Carroll, C. Ring, J. Shrimpton et al.
    Pages 71-77

  10. MAO inhibitory side effects of neuroleptics and platelet serotonin content in schizophrenic patients

    • Z. Mészáros, D. Borcsiczky, M. Máté, J. Tarcali, K. Tekes, K. Magyar
    Pages 79-85

  11. Modulation of glutamate neurotoxicity in the transformed cell culture by monoamine oxidase inhibitors, clorgyline and deprenyl

    • O. Yu. Abakumova, O. V. Podobed, T. A. Tsvetkova, I. V. Yakusheva, T. A. Moskvitina, L. I. Kondakova et al.
    Pages 87-91

  12. A cell culture model of cerebral ischemia as a convenient system to screen for neuroprotective drugs

    • J. Ekblom, H. Garpenstrand, O. Tottmar, J. A. Prince, L. Oreland
    Pages 93-98

  13. Neuroprotection by selegiline and other MAO inhibitors

    • G. Stern
    Pages 99-107

  14. The neuroprotective and neuronal rescue effects of (—)-deprenyl

    • K. Magyar, B. Szende, J. Lengyel, J. Tarczali, I. Szatmáry
    Pages 109-123

  15. Oxidation of N-methyl(R)salsolinol: involvement to neurotoxicity and neuroprotection by endogenous catechol isoquinolines

    • M. Naoi, W. Maruyama, T. Kasamatsu, P. Dostert
    Pages 125-138

  16. Substrate regulation of monoamine oxidases

    • R. R. Ramsay
    Pages 139-147

  17. Monoamine oxidases and related amine oxidases as phase I enzymes in the metabolism of xenobiotics

    • M. Strolin Benedetti, K. F. Tipton
    Pages 149-171

  18. Monoamine oxidases: from brain maps to physiology and transgenics to pathophysiology

    • J. G. Richards, J. Saura, J. M. Luque, A. M. Cesura, J. Gottowik, P. Malherbe et al.
    Pages 173-187

  19. Structure-function relationships of mitochondrial monoamine oxidase A and B: chimaeric enzymes and site-directed mutagenesis studies

    • A. M. Cesura, J. Gottowik, G. Lang, P. Malherbe, M. Da Prada
    Pages 189-200

  20. Deamination of methylamine and angiopathy; toxicity of formaldehyde, oxidative stress and relevance to protein glycoxidation in diabetes

    • P. H. Yu
    Pages 201-216
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Keywords

About this book

Monoamine oxidase (MAO) is linked to psychiatric and neurological disorders, because inhibitors of the enzyme are used clinically for treatment of affective disorders and Parkinson’s disease. One of the interesting new aspects of MAO is the occurrence in the human population of deletions of genes coding for one or the other enzyme subtype (A or B). This leads to the possibility of a genetic basis for psychiatric disorders based on MAO. Subjects with deletions of type A or B, and combined deletions, have been described. In the first group of 6 papers in this book, the occurrence and characterization of these phenotypes, as well as the structure of MAO genes, is explored. Advances in the biochemistry of MAO subtypes and their physiological function and localization in brain and periphery is included. Other sections of the book deal with the neuroprotective action of MAO inhibitors and their pharmacology, especially the pharmacology of new MAO-B inhibitors.

Reviews

"... the book is of particular value and a rich source of information for basic neuroscientists in the field. But it also can be of substantial interest to the rest of the neuroscientific community to get a glimpse of the current status of research in the field of MAO.” Acta Neurologica Belgica

Editors and Affiliations

  • Department of Pharmacology, The Bruce Rappaport Faculty of Medicine, Technion — Israel Institute of Technology, Haifa, Israel

    J. P. M. Finberg, M. B. H. Youdim

  • Clinical Neurochemistry, Department of Psychiatry, University of Würzburg, Federal Republic of Germany

    P. Riederer

  • Biochemistry Department, Trinity College, Dublin, Ireland

    K. F. Tipton

Bibliographic Information

  • Book Title: MAO - The Mother of all Amine Oxidases

  • Editors: J. P. M. Finberg, M. B. H. Youdim, P. Riederer, K. F. Tipton

  • Series Title: Journal of Neural Transmission. Supplementa

  • DOI: https://doi.org/10.1007/978-3-7091-6499-0

  • Publisher: Springer Vienna

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Wien 1998

  • Hardcover ISBN: 978-3-211-83038-3Published: 24 March 1998

  • Softcover ISBN: 978-3-211-83037-6Published: 23 March 1998

  • eBook ISBN: 978-3-7091-6499-0Published: 01 December 2013

  • Series ISSN: 0303-6995

  • Edition Number: 1

  • Number of Pages: XIX, 355

  • Additional Information: Special edition of Journal of Neural Transmission, Suppl. 52

  • Topics: Neurology, Psychiatry, Neurosciences, Pharmacology/Toxicology, Biochemistry, general

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