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  • © 2001

Protein Expression in Down Syndrome Brain

Editors:

  1. Gert Lubec

    1. Universität-Kinderklinik, Wien, Austria

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Table of contents (30 chapters)

  1. Front Matter

    Pages I-X
    PDF
  2. PDF
  3. PDF
  4. PDF

  5. Deterioration of the transcriptional, splicing and elongation machinery in brain of fetal Down Syndrome

    • M. Freidl, T. Gulesserian, G. Lubec, M. Fountoulakis, B. Lubec
    Pages 47-57
    PDF
  6. PDF
  7. PDF

  8. Glial-neurotrophic mechanisms in Down syndrome

    • P. G. Nelson, S. K. McCune, A. M. Ades, K. B. Nelson
    Pages 85-94
    PDF
  9. PDF

  10. Decreased protein levels of complex I 30-kDa subunit in fetal Down syndrome brains

    • S. H. Kim, M. Fountoulakis, M. Dierssen, G. Lubec
    Pages 109-116
    PDF
  11. PDF

  12. Functional genomics of Down syndrome: a multidisciplinary approach

    • M. Dierssen, E. Martí, C. Pucharcós, V. Fotaki, X. Altafaj, K. Casas et al.
    Pages 131-148
    PDF

  13. Unaltered expression of Fas (CD95/APO-1), Caspase-3, Bcl-2 and Annexins in brains of fetal Down syndrome: evidence against increased apoptosis

    • E. Engidawork, N. Balic, J.-F. Juranville, M. Fountoulakis, M. Dierssen, G. Lubec
    Pages 149-162
    PDF

  14. Alteration of caspases and other apoptosis regulatory proteins in Down syndrome

    • T. Gulesserian, E. Engidawork, B. C. Yoo, N. Cairns, G. Lubec
    Pages 163-179
    PDF
  15. PDF
  16. PDF

  17. Carbohydrate handling enzymes in fetal Down Syndrome brain

    • E. Kitzmueller, S. Greber, G. Lubec, M. Fountoulakis
    Pages 203-210
    PDF
  18. PDF
  19. PDF

  20. Effects of a single transdermal nicotine dose on cognitive performance in adults with Down syndrome

    • G. Bernert, M. Sustrova, E. Sovcikova, R. Seidl, G. Lubec
    Pages 237-245
    PDF
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About this book

When we worked on Down Syndrome brain in the past we have been focus­ ing on adult brain. This was a major step forwards as most work on Down Syndrome was carried out on fibroblasts or other tissues and, moreover, we introduced proteomics to identify and quantify brain protein expression. We considered evaluation of brain protein expression in Down Syndrome brain by and by more important than gene hunting at the nucleic acid level realiz­ ing the long unpredictable way from RNA to protein. The availability of fetal samples along with the proteomic appproach stimulated and reinforced studies on Down Syndrome brain. And indeed, it was found out that some observations on aberrant protein expression in adult Down Syndrome brain could not be verified in the fetal samples indi­ cating that neurodegeneration in adult Down Syndrome brain may have been responsible rather than trisomy 21. Using brains from the early second trimester of gestation led to the generation of a series of clues for the under­ standing of aberrant wiring of the brain in Down Syndrome and enabled the determination of altered key functions in early life; e. g. undetectably low drebrin was observed in Down Syndrome cortex, an integral constituent and marker for dendritic spines, main effectors of cross-talk between neurons. In addition, evaluation of the nature of the neuronal deficits in terms of neuro­ transmission markers could be established as well as neuronal density in fetal Down Syndrome cortex.
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Keywords

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Editors and Affiliations

  • Universität-Kinderklinik, Wien, Austria

    Gert Lubec

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Bibliographic Information

  • Book Title: Protein Expression in Down Syndrome Brain

  • Editors: Gert Lubec

  • DOI: https://doi.org/10.1007/978-3-7091-6262-0

  • Publisher: Springer Vienna

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Wien 2001

  • Hardcover ISBN: 978-3-211-83732-0Published: 15 October 2001

  • eBook ISBN: 978-3-7091-6262-0Published: 01 December 2013

  • Edition Number: 1

  • Number of Pages: X, 374

  • Additional Information: Special edition of Journal of Neural Transmission, Supplement 61, 2001

  • Topics: Neurosciences, Molecular Medicine, Human Genetics, Pediatrics, Pathology, Psychiatry

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Download book PDF

Buy it now

Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

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