Cerebral Vasospasm

1. Front Matter

   Pages I-XI

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2. Is Cerebral Vasospasm still a Clinical Problem?

   1. Is Cerebral Vasospasm still a Clinical Problem?

      • R. W. Seiler, R. Binggeli

      Pages 1-4

3. Basic Science and Experimental Vasospasm

   1. Front Matter

      Pages 5-5

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   2. Molecular Biology of Vasospasm

      1. Pathophysiology and Molecular Genetics of Vasospasm

         • R. L. Macdonald

         Pages 7-11

      2. Identification of Genes Differentially Expressed in Canine Vasospastic Cerebral Arteries after Subarachnoid Hemorrhage

         • H. Kasuya, H. Onda, A. Kawashima, A. Sasahara, T. Hori

         Pages 13-16

      3. Complimentary Deoxyribonucleic Acid Array Analysis of Cerebral Arteries after Experimental Subarachnoid Hemorrhage

         • Z.-D. Zhang, L. S. Marton, S. Ono, T Komuro, B. Weir, R. L. Macdonald

         Pages 17-19

      4. Which Protein Kinase C Isoforms are Involved in the Development of Vasospasm after Subarachnoid Haemorrhage?

         • S. Nishizawa, K. Obara, K. Nakayama, M. Koide, T. Yokoyama, N. Yokota et al.

         Pages 21-24

      5. Role of Mitogen-Activated Protein Kinase in the Contractions of Rabbit Basilar Artery Induced by Hemolysate, Oxyhemoglobin, and Bloody CSF

         • A. Y. Zubkov, K. Shadon Rollins, B. McGehee, A. D. Parent, J. H. Zhang

         Pages 25-27

      6. Apoptosis in Basilar Endothelial Cells in a Canine Double Hemorrhage Model

         • A. Y. Zubkov, R. E. Tibbs, B. Clower, K. Ogihara, K. Aoki, J. H. Zhang

         Pages 29-31

      7. Delayed Clot Removal and Experimental Vasospasm

         • Z.-D. Zhang, B. Yamini, T. Komuro, S. Ono, L. Johns, L. S. Marton et al.

         Pages 33-35

      8. Influence of Brain Natriuretic Peptide on Phenotypic Change of Cerebral Vasculature

         • J. Hansen-Schwartz, G. Sviri, L. Edvinsson

         Pages 37-40

      9. Brain Natriuretic Peptide and Cerebral Vasospasm in Subarachnoid Hemorrhage

         • G. E. Sviri, B. Shik, B. Raz, J. F. Soustiel

         Pages 41-43

      10. Phosphatidylcholine Peroxidized by Hemoglobin Increases Intracellular Calcium in Dog Basilar Artery Smooth Muscle Cells

          • B. S. Jahromi, T. Komuro, R. L. Macdonald, L. S. Marton, B. K. Weir

          Pages 45-47

      11. Importance of Rho-Kinase-Mediated Phosphorylation of Myosin Light Chain in Vasospasm

          • M. Sato, E. Tani, H. Fujikawa, I. Yamaura, N. Arita, K. Kaibuchi

          Pages 49-54

      12. Role of MAPK in Chronic Cerebral Vasospasm

          • K. Aoki, A. Y. Zubkov, R. E. Tibbs, T. Meguro, J. H. Zhang

          Pages 55-57

   3. Endothelin and Nitric Oxide

      1. Endothelin: The “Prime Suspect” in Cerebral Vasospasm

         • M. Zuccarello

         Pages 61-65

      2. Nitric Oxide and Vasospasm

         • R. M. Pluta, B. G. Thompson, J. K. Afshar, R. J. Boock, B. Iuliano, E. H. Oldfield

         Pages 67-72

      3. Effect of Endothelin-Converting Enzyme Inhibitors on big Endothelin-1 Induced Contraction of Rabbit Basilar Artery

         • M. Zimmermann, C. Jung, A. Raabe, O. Spanehl, V. Seifert

         Pages 73-75

      4. The Role of Endothelin-1 as Predictor of the Symptomatic Vasospasm in Acute Stage of Subarachnoid Haemorrhage

         • J M. Kim, K. H. Bak, C. H. Kim, I. K. Park, S. J. Oh, H. K. Choi

         Pages 77-79

   4. Gene Therapy

      1. Gene Therapy for Vasospasm

         • J. M. Findlay

         Pages 83-87

Cerebral vasospasm remains a major clinical problem in patients with subarachnoid hemorrhage. Neuroprotection with calcium antagonists, hemodynamic therapy and interventional angioplasty have an established role in the management of this disease, but an effective single drug for prevention or treatment of the vasospasm is still lacking. This book contains selected contributions to the 7th International Conference on Cerebral Vasospasm held in Interlaken, Switzerland, in June 2000. Part I of the book concentrates on basic science and experimental vasospasm. The molecular biology of vasospasm, the role of endothelin and nitric oxide as well as the potential of gene therapy are presented. Part II concentrates on the diagnosis and therapy of clinical vasospasm. New diagnostic tools are presented, including diffusion and perfusion-weighted MRI, MR spectroscopy and microdialysis with metabolic monitoring. Leaders in the field discuss the current indications and results of endovascular treatment of cerebral vasospasm. The latter chapters are devoted to the treatment of clinical vasospasm with new drugs and to the prevention and treatment of ischemic deficits with neuroprotective drugs and hemodynamic therapy. The book provides the state-of-the-art in the major subjects of the molecular biology of vasoconstriction and experimental vasospasm as well as the diagnosis and treatment of clinical vasospasm.

• cerebral vasospasm
• clinical vasospasm
• diagnosis
• magnetic resonance imaging (MRI)
• neuroprotection
• vasospasm

• Inselspital, Neurochirurgische Univ.-Klinik, Bern, Switzerland

  R. W. Seiler

• Klinikum Großhadern, Neurochirurgische Univ.-Klinik, München, Germany

  H.-J. Steiger

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