Disorders of Sleep and Circadian Rhythms in Parkinson's Disease

1. Front Matter

   Pages i-xii

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2. Part I

   1. Front Matter

      Pages 1-1

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   2. Regulation of Sleep and Wake Homeostasis

      • Cathy A. Goldstein, Ronald D. Chervin

      Pages 3-18

   3. Neurochemistry of the Sleep-Wake Cycle in Parkinson’s Disease

      • Amanda A. H. Freeman

      Pages 19-33

   4. Impaired Sleep and Alertness in Parkinson’s Disease: “What Did We Learn from Animal Models?”

      • Pierre-Hervé Luppi, Olivier Clément, Sara Valencia Garcia, Frédéric Brischoux, Patrice Fort

      Pages 35-49

   5. Objective Measures of the Sleep–Wake Cycle in Parkinson’s Disease

      • Valérie Cochen De Cock

      Pages 51-60

   6. Subjective Assessment of Sleep and Sleepiness in Parkinson’s Disease

      • Joan Santamaria

      Pages 61-76

3. Part II

   1. Front Matter

      Pages 77-77

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   2. Insomnia in Parkinson’s Disease

      • Margaret Park, Cynthia L. Comella

      Pages 79-91

   3. Sleep Disordered Breathing in Parkinson’s Disease

      • Michael K. Scullin, Lynn Marie Trotti, Donald L. Bliwise

      Pages 93-106

   4. Excessive Daytime Somnolence Associated with Parkinson’s Disease

      • James Battista, Renee Monderer, Michael Thorpy

      Pages 107-116

   5. Dysregulation of Circadian System in Parkinson’s Disease

      • Aleksandar Videnovic

      Pages 117-129

   6. REM Sleep Behavior Disorder

      • Michael J. Howell, Carlos H. Schenck

      Pages 131-144

   7. Quality Control for Diagnosis of REM Sleep Behavior Disorder: Criteria, Questionnaires, Video, and Polysomnography

      • Birgit Frauscher, Birgit Högl

      Pages 145-157

   8. Restless Legs Syndrome and Periodic Limb Movements in Parkinson’s Disease

      • William G. Ondo

      Pages 159-171

   9. Fatigue and Sleepiness in Parkinson’s Disease Patients

      • Elisabeth Svensson

      Pages 173-181

   10. Cognition and the Sleep–Wake Cycle in Parkinson’s Disease

       • Jean-Francois Gagnon, Ronald B. Postuma, Gabrielle Lyonnais-Lafond

       Pages 183-194

   11. Impact of Surgical Therapies on Sleep and Alertness in Parkinson’s Disease

       • Amy W. Amara, Harrison C. Walker

       Pages 195-207

   12. Sleep Disorders in Atypical Parkinsonisms

       • Alex Iranzo

       Pages 209-221

4. Back Matter

   Pages 223-229

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This book is the first to take into account the rapidly growing body of knowledge on the relation between sleep and PD. Gathering contributions from internationally recognized experts, it provides a unique source of in-depth information on sleep and circadian dysregulation in Parkinson’s disease. The book is divided into two parts: the first comprises chapters on normal sleep-wake homeostasis, followed by changes that occur in PD and discussions of available tools for the assessment of sleep-wake cycles in PD. In the second part, sleep and circadian disorders associated with PD are described in individual chapters, including sections on epidemiology, etiology, pathogenesis, differential diagnosis, and treatment. Controversies in the field, such as the relations between cognition and sleep, fatigue and sleepiness, and the potential impact of surgical therapies on sleep-wake cycles are discussed separately. The book closes with a chapter on future directions and unmet needs in the field of sleep, circadian biology and PD. This comprehensive text offers a readily accessible resource for clinicians and researchers alike, addressing the needs of neurologists, sleep and movement disorders specialists, and all trainees and allied health professionals involved in the care of patients affected by Parkinson’s disease.

• Circadian
• PD
• Parkinson's Disease
• REM Behavior Disorders
• Sleep
• Somnolence

“This book, written and edited by internationally recognized clinician-scientists in the field, is a welcome addition to the sleep medicine, movement disorder, and neuropsychiatric literature. The authors wish to discuss how ‘specific sleep disorders have emerged as important early manifestations of synuclein related neurodegeneration specific for PD’. … This is an excellent, unique, and useful book targeted at clinicians involved in the care of patients with PD and related disorders.” (Michael Joel Schrift, Doody’s Book Reviews, October, 2015)

• Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA

  Aleksandar Videnovic

• Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria

  Birgit Högl

Dr. Aleksandar Videnovic is Assistant Professor of Neurology at Northwestern University Feinberg School of Medicine in Chicago, USA. His clinical and research expertise is in Parkinson's Disease and movement disorders and in Sleep Medicine. Dr. Videnovic's research has been focused on sleep dysfunctions in movement disorders with an emphasis on Parkinson's disease. His research is supported by the United States National Institute of Health, the American Academy of Neurology Foundation, the Michael J. Fox Foundation for Parkinson Research, and the National Parkinson Foundation. Dr. Birgit Högl is Professor of Neurology at Innsbruck Medical University in Innsbruck, Austria. She is a world-renowned expert in the field of Sleep Medicine. Professor Högl has authored many landmark studies related to the interface of sleep and movement disorders, in particular Parkinson's disease, REM Sleep Behavior Disorder and Restless Legs Syndrome.

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