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Hydrogen Sulfide and its Therapeutic Applications

  • Book
  • © 2013

Overview

Editors:
  1. Hideo Kimura

    1. National Institut of Neuroscience, Tokyo, Japan

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  • Gives a broad overview to the topic from chemical and biochemical basics to therapeutic application

  • First volume on the topic with interdisciplinary scope

  • Respective topics discussed by experts in basic science and clinical application

  • Includes supplementary material: sn.pub/extras

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-ix
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  2. Enzymology of Hydrogen Sulfide Turnover

    • Nicole Motl, Pramod Yadav, Ruma Banerjee
    Pages 1-35

  3. Hydrogen Sulfide as an Oxygen Sensor

    • Kenneth R. Olson
    Pages 37-62

  4. Multiple Roles of H2S in Inflammation: A New Class of Therapeutics?

    • Ling Li, Mohamed Shirhan Bin Mohamed, Philip K. Moore
    Pages 63-82

  5. Signaling Mechanisms Underlying the Hydrogen Sulfide Effects: Identification of Hydrogen Sulfide “Receptors”

    • Yi-Chun Zhu
    Pages 83-107

  6. Hydrogen Sulfide: Its Production, Release and Functions

    • Kyle L. Flannigan, John L. Wallace
    Pages 109-125

  7. Hydrogen Sulfide: Physiological and Pathophysiological Functions

    • Yi Tong Liu, Jin-Song Bian
    Pages 127-156

  8. Biological Effects of H2S Inhalation and Its Therapeutic Potential

    • Fumito Ichinose
    Pages 157-171

  9. H2S as a Bacterial Defense Against Antibiotics

    • Lyly Luhachack, Evgeny Nudler
    Pages 173-180

  10. Hydrogen Sulfide-Mediated Cellular Signaling and Cytoprotection

    • Hideo Kimura
    Pages 181-202

  11. Back Matter

    Pages 203-207
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Keywords

About this book

The metabolism of sulfur especially by sulfurtransferases had been intensively studied in mid 1900’s.  Three enzymes, cystathionine β–synthase (CBS), cystathionine γ–lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST) were found to have the capacity to produce H2S in vitro.  However, H2S was recognized simply as a by-product of the metabolic pathways or as a marker for evaluating the activity of enzymes rather than as a physiological active molecule.   In the late 1980’s relatively high concentrations of sulfide were measured in the brain that led to the successive studies of identifying the physiological functions of H2S.  Recently, the steady-state concentrations of H2S have been re-evaluated and found to be much less than that initially measured.  However, despite these differences, such re-evaluations served to further confirm the existence of H2S in mammalian tissues.  H2S is produced in almost every organ and plays various roles such as neuromodulation, vasodilation, insulin release, inflammation, angiogenesis and cytoprotection. The unregulated production of H2S and improper responses of target molecules are involved in the pathogenesis of various diseases.  This book focuses on these topics as well as on the recent progress in the biology and the therapeutic development of this molecule.

Editors and Affiliations

  • National Institut of Neuroscience, Tokyo, Japan

    Hideo Kimura

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