Overview
- Editors:
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Klaudia Brix
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SCHOOL OF ENGINEERING AND SCIENCE, JACOBS UNIVERSITY BREMEN, Bremen, Germany
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Walter Stöcker
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Institute of Zoology, Johannes Gutenberg University Mainz, Mainz, Germany
- Written by designated experts in the field defined models are described
- Ensures a better understanding of biological significance of proteinases
- Clearly shows the diversity and networking of enzymes
- Includes supplementary material: sn.pub/extras
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Table of contents (15 chapters)
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- Antonio Baici, Marko Novinec, Brigita Lenarčič
Pages 37-84
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- Klaudia Brix, Christopher J. Scott, Margarete M. S. Heck
Pages 85-125
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- Ann H. Erickson, Ciro Isidoro, Lukas Mach, John S. Mort
Pages 127-173
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- Stefan Tholen, Maria Magdalena Koczorowska, Zon Weng Lai, Joern Dengjel, Oliver Schilling
Pages 175-216
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- Martina Gansz, Ursula Kern, Christoph Peters, Thomas Reinheckel
Pages 217-233
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- Walter Stöcker, F. Xavier Gomis-Rüth
Pages 235-263
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- Andreas Flütsch, Markus G. Grütter
Pages 265-302
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- Joachim Grötzinger, Stefan Rose-John
Pages 303-318
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- Holger Cynis, Stefan F. Lichtenthaler, Leona Wagner, Hans-Ulrich Demuth
Pages 319-371
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- S. Gaylen Bradley, Toni M. Antalis, Judith S. Bond
Pages 373-393
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- John Anagli, Kevin K. W. Wang, Yasuko Ono, Hiroyuki Sorimachi
Pages 395-431
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- Hideaki Nagase, Gillian Murphy
Pages 433-469
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- Agnès Noel, Nor Eddine Sounni
Pages 471-489
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- Bonnie F. Sloane, Karin List, Barbara Fingleton, Lynn Matrisian
Pages 491-550
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Back Matter
Pages 551-564
About this book
Proteolysis is an irreversible posttranslational modification affecting each and every protein from its biosynthesis to its degradation. Limited proteolysis regulates targeting and activity throughout the lifetime of proteins. Balancing proteolysis is therefore crucial for physiological homeostasis. Control mechanisms include proteolytic maturation of zymogens resulting in active proteases and the shut down of proteolysis by counteracting endogenous protease inhibitors. Beyond the protein level, proteolytic enzymes are involved in key decisions during development that determine life and death – from single cells to adult individuals. In particular, we are becoming aware of the subtle role that proteases play in signaling events within proteolysis networks, in which the enzymes act synergistically and form alliances in a web-like fashion. Proteases come in different flavors. At least five families of mechanistically distinct enzymes and even more inhibitor families are known to date, many family members are still to be studied in detail. We have learned a lot about the diversity of the about 600 proteases in the human genome and begin to understand their physiological roles in the degradome. However, there are still many open questions regarding their actions in pathophysiology. It is in this area where the development of small molecule inhibitors as therapeutic agents is extremely promising. Approaching proteolysis as the most important, irreversible post-translational protein modification essentially requires an integrated effort of complementary research disciplines. In fact, proteolytic enzymes seem as diverse as the scientists working with these intriguing proteins. This book reflects the efforts of many in this exciting field of research where team and network formations are essential to move ahead.
Editors and Affiliations
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SCHOOL OF ENGINEERING AND SCIENCE, JACOBS UNIVERSITY BREMEN, Bremen, Germany
Klaudia Brix
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Institute of Zoology, Johannes Gutenberg University Mainz, Mainz, Germany
Walter Stöcker
