Anticarbohydrate Antibodies

1. Front Matter

   Pages i-xiii

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2. Multidisciplinary Approaches to Study O-Antigen: Antibody Recognition in Support of the Development of Synthetic Carbohydrate-Based Enteric Vaccines

   • François-Xavier Theillet, Pierre Chassagne, Muriel Delepierre, Armelle Phalipon, Laurence A. Mulard

   Pages 1-36

3. Synthetic Oligosaccharide Bacterial Antigens to Produce Monoclonal Antibodies for Diagnosis and Treatment of Disease Using Bacillus anthracis as a Case Study

   • Matthias A. Oberli, Tim Horlacher, Daniel B. Werz, Peter H. Seeberger

   Pages 37-54

4. The Role of Sialic Acid in the Formation of Protective Conformational Bacterial Polysaccharide Epitopes

   • Harold J. Jennings

   Pages 55-73

5. Antibody Recognition of Chlamydia LPS: Structural Insights of Inherited Immune Responses

   • Ryan J. Blackler, Sven Müller-Loennies, Lore Brade, Paul Kosma, Helmut Brade, Stephen V. Evans

   Pages 75-120

6. Designing a Candida albicans Conjugate Vaccine by Reverse Engineering Protective Monoclonal Antibodies

   • David R. Bundle, Casey Costello, Corwin Nycholat, Tomasz Lipinski, Robert Rennie

   Pages 121-145

7. The Neutralizing Anti-HIV Antibody 2G12

   • Renate Kunert

   Pages 147-160

8. Immune Recognition of Parasite Glycans

   • Rick M. Maizels, James P. Hewitson

   Pages 161-180

9. Human IgE Antibodies Against Cross-Reactive Carbohydrate Determinants

   • Wolfgang Hemmer

   Pages 181-202

10. Structural Glycobiology of Antibody Recognition in Xenotransplantation and Cancer Immunotherapy

    • Mark Agostino, William Farrugia, Mauro S. Sandrin, Andrew M. Scott, Elizabeth Yuriev, Paul A. Ramsland

    Pages 203-228

11. Carbohydrate Mimetic Peptide Vaccines

    • Somdutta Saha, Anastas Pashov, Behjatolah Monzavi-Karbassi, Ann Marie Kieber-Emmons, Akashi Otaki, Ramachandran Murali et al.

    Pages 229-254

12. Antitumor Vaccines Based on Synthetic Mucin Glycopeptides

    • Ulrika Westerlind, Horst Kunz

    Pages 255-281

13. Glycan Microarray Analysis of Tumor-Associated Antibodies

    • Ola Blixt, Irene Boos, Ulla Mandel

    Pages 283-306

14. A Novel Mannose 6-phosphate Specific Antibody Fragment for Diagnosis of Mucolipidosis type II and III

    • Sandra Pohl, Thomas Braulke, Sven Müller-Loennies

    Pages 307-325

15. Anti-glycolipid Antibodies in Guillain-Barré Syndrome and Related Neuropathies: Therapeutic Strategies for Disease Treatment

    • Robert K. Yu, Seigo Usuki, Toshio Ariga

    Pages 327-359

16. Computational Techniques Applied to Defining Carbohydrate Antigenicity

    • Robert J. Woods, Austin B. Yongye

    Pages 361-383

17. The Interaction of Saccharides with Antibodies. A 3D View by Using NMR

    • Filipa Marcelo, F. Javier Cañada, Jesús Jiménez-Barbero

    Pages 385-402

18. Determination of Antibody Affinity by Surface Plasmon Resonance

    • Roger MacKenzie, Sven Müller-Loennies

    Pages 403-429

19. Back Matter

    Pages 431-438

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Many pathogens and aberrant malignant cells express unique carbohydrates on their surface representing attractive targets for vaccine design. Considerable progress has recently been made in the identification of novel carbohydrate based vaccines and a large number has reached clinical phase studies. The success of several licensed carbohydrate based vaccines against bacterial pathogens such as Haemophilus influenzae type b, Neisseria meningitidis or Streptococcus pneumoniae demonstrates their great potential. However, the study of anti-carbohydrate antibodies is technically challenging and partly because of low affinities and promiscuous specificity they have not been medically exploited to full potential. The study of antibody specificities and identification of protective carbohydrate epitopes lies at the heart of successful vaccine design. In addition to therapy, antibodies in general serve as diagnostic tools in medical and scientific laboratories. In this setting high affinity and exquisite specificity are important factors for their successful use. “Anticarbohydrate Antibodies – from molecular basis to clinical application” compiles current knowledge on the immunological recognition of carbohydrates by the adaptive immune system from a molecular perspective providing fundamental insight needed for advancing clinically relevant diagnostics and therapeutic applications. Based on significant progress in the fields of glycoimmunology and structural biology in recent years, the book comprehensively reviews the state-of-the-art in defining the key elements of carbohydrate recognition by antibodies, the molecular mimicry of carbohydrate epitopes as well as the molecular features leading to specific and relaxed binding modes. Backed-up by a combination of modern technologies to elucidate structural details of carbohydrate-antibody interactions, biomedically important carbohydrate antigens from viral, bacterial, parasite, insect and tumor cells have beenanalyzed in in-depth reviews written by well-known experts in the field. Fundamental knowledge of these molecular mechanisms eventually provides a rational basis to improve efficacy of carbohydrate-based vaccines and to further refine diagnostic tools in detection of pathogens and malignant cells.

• antibodies
• anticarbohydrate antibodies
• immune response
• protein-carbohydrate interaction
• vaccines

• , Department für Chemie, Universität für Bodenkultur Wien, Wien, Austria

  Paul Kosma

• , Zentrum für Medizin und Biowissenschafte, Forschungszentrum Borstel, Borstel, Germany

  Sven Müller-Loennies

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