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Gene Vaccines

  • Book
  • © 2012

Overview

Editors:
  1. Josef Thalhamer

    1. , Department of Molecular Biology, University of Salzburg, Salzburg, Austria

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  2. Richard Weiss

    1. , Department of Molecular Biology, University of Salzburg, Salzburg, Austria

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    You can also search for this editor in PubMed   Google Scholar

  3. Sandra Scheiblhofer

    1. , Department of Molecular Biology, University of Salzburg, Salzburg, Austria

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    You can also search for this editor in PubMed   Google Scholar

  • Only updated volume on gene vaccines focus on the most promising

  • Approaches towards gene vaccination

  • Approaches close to or already in clinical use objective comparison of different methods and protocols

  • Includes supplementary material: sn.pub/extras

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xi
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  2. General Mechanisms of Gene Vaccines

    • Richard Weiss, Viggo Van Tendeloo, Sandra Scheiblhofer, Josef Thalhamer
    Pages 1-35

  3. Strategies to Improve DNA Vaccine Potency: HPV-Associated Cervical Cancer as a Model System

    • Chien-Fu Hung, Barbara Ma, Yijie Xu, T.-C. Wu
    Pages 37-65

  4. Immune-Activating Mechanisms of Replicase-Based DNA and RNA Vaccines and Their Role in Immune-Apoptosis

    • Wolfgang W. Leitner
    Pages 67-88

  5. Cytokine Genes as Molecular Adjuvants for DNA Vaccines

    • Bin Wang, Youmin Kang, Richard Ascione
    Pages 89-107

  6. Pharmaceutical Non-Viral Formulations for Gene Vaccines

    • Glen Perera, Andreas Bernkop-Schnürch
    Pages 109-125

  7. Rational Design of Formulated DNA Vaccines: The DermaVir Approach

    • Eszter Nátz, Julianna Lisziewicz
    Pages 127-143

  8. Improvement of DNA Vaccines by Electroporation

    • Arielle A. Ginsberg, Xuefei Shen, Natalie A. Hutnick, David B. Weiner
    Pages 145-162

  9. Electroporation Based TriGrid™ Delivery System (TDS) for DNA Vaccine Administration

    • Drew Hannaman
    Pages 163-181

  10. Prime Boost Regimens for Enhancing Immunity: Magnitude, Quality of Mucosal and Systemic Gene Vaccines

    • Danushka K. Wijesundara, Charani Ranasinghe
    Pages 183-204

  11. Intralymphatic Vaccination

    • Thomas M. Kündig, Adrian Bot, Gabriela Senti
    Pages 205-221

  12. Messenger RNA Vaccines

    • Jochen Probst, Mariola Fotin-Mleczek, Thomas Schlake, Andreas Thess, Thomas Kramps, Karl-Josef Kallen
    Pages 223-245

  13. DNA and RNA Vaccines for Prophylactic and Therapeutic Treatment of Type I Allergy

    • Richard Weiss, Sandra Scheiblhofer, Elisabeth Rösler, Josef Thalhamer
    Pages 247-263

  14. Approved Veterinary Vaccines: Paving the Way to Products for Human Health

    • Matthias Giese
    Pages 265-283

  15. Current Status of Regulations for DNA Vaccines

    • Bettina Klug, Jens Reinhardt, James Robertson
    Pages 285-295

  16. Minicircle-DNA

    • Peter Mayrhofer, Michaela Iro
    Pages 297-310

  17. Industrial Manufacturing of Plasmid-DNA Products for Gene Vaccination and Therapy

    • Jochen Urthaler, Hermann Schuchnigg, Patrick Garidel, Hans Huber
    Pages 311-330
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Keywords

About this book

The induction of antigen-specific immune responses after in vivo transfection with expression plasmids has triggered a revolution of vaccine research. After a first hype, evoked by the fascinating options of this method, clinical studies did not reach the ambitious aims and a phase of disillusion ensued. It became obvious that Gene vaccines displayed a weaker immunogenicity in humans than had been observed in the mouse models. Meanwhile these hurdles have been overcome and gene vaccines undergo a renaissance. The present book gives an update of the “world of naked gene vaccines”, namely DNA and RNA vaccines. Its content ranges from general mechanisms, inherent immunostimulatory properties and the vast potential to modulate immune responses, to recent successful clinical studies and approved veterinary gene vaccines. Beyond the state-of-the-art of genetic immunization, the reader will be stimulated with a chapter addressing “burning questions”.

Editors and Affiliations

  • , Department of Molecular Biology, University of Salzburg, Salzburg, Austria

    Josef Thalhamer, Richard Weiss, Sandra Scheiblhofer

Bibliographic Information

  • Book Title: Gene Vaccines

  • Editors: Josef Thalhamer, Richard Weiss, Sandra Scheiblhofer

  • DOI: https://doi.org/10.1007/978-3-7091-0439-2

  • Publisher: Springer Vienna

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag/Wien 2012

  • Hardcover ISBN: 978-3-7091-0438-5Published: 26 September 2011

  • Softcover ISBN: 978-3-7091-1929-7Published: 23 August 2016

  • eBook ISBN: 978-3-7091-0439-2Published: 31 August 2011

  • Edition Number: 1

  • Number of Pages: XI, 330

  • Topics: Vaccine, Immunology, Medical Biochemistry

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