Melanoma Development

1. Front Matter

   Pages i-xi

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2. Introduction

   • Anja Bosserhoff, Luigi Strizzi

   Pages 1-5

3. Epidermal Melanocytes: Regulation of Their Survival, Proliferation, and Function in Human Skin

   • Zalfa A. Abdel-Malek, Viki B. Swope

   Pages 7-33

4. Melanoma Epidemiology

   • Marianne Berwick

   Pages 35-55

5. Melanoma Genetics and Genomics

   • Göran Jönsson, Hensin Tsao

   Pages 57-77

6. Transcriptional Regulation in Melanoma

   • Satoru Yokoyama, David E. Fisher

   Pages 79-103

7. miRNAs in Malignant Melanoma

   • Daniel W. Mueller, Anja Bosserhoff

   Pages 105-136

8. Altered Signal Transduction Pathways in Melanoma

   • Eric Lau, Ze’ev A. Ronai

   Pages 137-163

9. Proteases in Melanoma

   • Paola Zigrino, Cornelia Mauch

   Pages 165-179

10. Cell–Cell and Cell–Matrix Contacts in Melanoma and the Tumor Microenvironment

    • Silke Kuphal, Nikolas K. Haass

    Pages 181-215

11. Regulation of Apoptosis in Melanoma Cells: Targets for Therapeutic Strategies

    • Jürgen Eberle, Lothar F. Fecker

    Pages 217-233

12. Senescence

    • Helen Rizos, Lyndee L. Scurr

    Pages 235-254

13. Melanoma Stem Cells

    • Tobias Schatton, Markus H. Frank

    Pages 255-279

14. Lessons from Embryogenesis

    • Luigi Strizzi, Katharine M. Hardy, Elisabeth A. Seftor, Naira V. Margaryan, Dawn A. Kirschmann, Gina T. Kirsammer et al.

    Pages 281-296

15. Tumor Microenvironment for Melanoma Cells

    • Gao Zhang, Meenhard Herlyn

    Pages 297-307

16. Melanoma Model Systems

    • Birgit Schittek, Thomas Tüting

    Pages 309-335

17. New Therapeutic Approaches in Signaling

    • Keith T. Flaherty

    Pages 337-357

18. Immunotherapy of Melanoma: A New Era

    • Alexander M. M. Eggermont, Caroline Robert, Dirk Schadendorf

    Pages 359-372

19. Back Matter

    Pages 373-373

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The book provides comprehensive insights into molecular changes in malignant melanoma. The general mechanisms of melanoma growth and development are described, as well as new research findings. Our current knowledge on the molecules involved in cell transformation and tumor progression will soon lead to sophisticated, targeted therapies. Recent studies with targeted b-RAF inhibitors have given us grounds to hope that these therapies will be successful. Melanoma Development- Molecular Biology, Genetics and Clinical Application aims to contribute to this knowledge. Summarizing the newest data and presenting upcoming research areas in the field, the book will be of great interest to basic researchers and physicians working in the important fields of melanoma, cancer research, therapy and dermatology.

• Melanoma
• Senescence
• Stem Cells
• Tumor Microenvironment
• skin carcinoma

• , Molecular Pathology, Institute of Pathololgy, Regensburg, Germany

  Anja Bosserhoff

Anja Bosserhoff studied biology at the University of Bielefeld, Germany. She completed her PhD at the Department of Dermatology, University of Regensburg, Germany, in 1995. Between 1995 and 1998 she received her postdoctoral education at the Institute for Pathology, University of Regensburg. In 1998 and 1999 she served as assistant researcher at the Institute for Pathology in Regensburg and at the Rhine-Wesfalia-Technical –University (RWTH) in Aachen, Germany, respectively. In 2000 she became Professor in general and molecular pathology of the cell at the University of Aachen (Habilitation). Since 2002 Anja Bosserhoff has been Full Professor at the Institute for Pathology and Head of the Division of Molecular Pathology in Regensburg. She has published more than 150 papers in international renowned high impact journals, contributed to several book projects and written several review articles. She received various national and international research awards, among which the “Deutscher Hautkrebspreis” in 2007.

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