Basic Methods Handbook for Clinical Orthopaedic Research

1. Front Matter

   Pages i-xiv

   PDF

2. Evidence Based Medicine in Orthopaedics

   1. Front Matter

      Pages 1-1

      PDF

   2. What Is Evidence-Based Medicine?

      • Eleonor Svantesson, Eric Hamrin Senorski, Jón Karlsson, Olufemi R. Ayeni, Kristian Samuelsson

      Pages 3-10

   3. What Is the Hierarchy of Clinical Evidence?

      • Vishal S. Desai, Christopher L. Camp, Aaron J. Krych

      Pages 11-22

   4. Bias and Confounding

      • Naomi Roselaar, Magaly Iñiguez Cuadra, Stephen Lyman

      Pages 23-32

   5. Ethical Consideration in Orthopedic Research

      • Jason L. Koh, Diego Villacis

      Pages 33-42

   6. Conflict of Interest

      • Michael Hantes, Apostolos Fyllos

      Pages 43-47

   7. Ethics in Clinical Research

      • Naomi Roselaar, Niv Marom, Robert G. Marx

      Pages 49-54

3. How to Get Started with Clinical Research?

   1. Front Matter

      Pages 55-55

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   2. How to Get Started: From Idea to Research Question

      • Lachlan M. Batty, Timothy Lording, Eugene T. Ek

      Pages 57-63

   3. How to Write a Study Protocol

      • Lukas B. Moser, Michael T. Hirschmann

      Pages 65-73

   4. The Ethical Approval Process

      • Karren Takamura, Frank Petrigliano

      Pages 75-81

   5. How to Assess Patient’s Outcome?

      • Yuichi Hoshino, Alfonso Barnechea

      Pages 83-88

   6. Basics of Outcome Assessment in Clinical Research

      • Monique C. Chambers, Sarah M. Tepe, Lorraine A. T. Boakye, MaCalus V. Hogan

      Pages 89-95

   7. Types of Scoring Instruments Available

      • José F. Vega, Kurt P. Spindler

      Pages 97-109

   8. Health Measurement Development and Interpretation

      • Andrew Firth, Dianne Bryant, Jacques Menetrey, Alan Getgood

      Pages 111-120

   9. How to Document a Clinical Study and Avoid Common Mistakes in Study Conduct?

      • Caroline Mouton, Laura De Girolamo, Daniel Theisen, Romain Seil

      Pages 121-132

   10. Framework for Selecting Clinical Outcomes for Clinical Trials

       • Adam J. Popchak, Andrew D. Lynch, James J. Irrgang

       Pages 133-142

   11. Advances in Measuring Patient-Reported Outcomes: Use of Item Response Theory and Computer Adaptive Tests

       • Andrew D. Lynch, Adam J. Popchak, James J. Irrgang

       Pages 143-150

4. Basics in Statistics: Statistics Made Simple!

   1. Front Matter

      Pages 151-151

      PDF

This book is designed to meet the needs of both novice and senior researchers in Orthopaedics by providing the essential, clinically relevant knowledge on research methodology that is sometimes overlooked during training. Readers will find a wealth of easy-to-understand information on all relevant aspects, from protocol design, the fundamentals of statistics, and the use of computer-based tools through to the performance of clinical studies with different levels of evidence, multicenter studies, systematic reviews, meta-analyses, and economic health care studies. A key feature is a series of typical case examples that will facilitate use of the volume as a handbook for most common research approaches and study types. Younger researchers will also appreciate the guidance on preparation of abstracts, poster and paper presentations, grant applications, and publications. The authors are internationally renowned orthopaedic surgeons with extensive research experience and the book is published in collaboration with ISAKOS.

• Manuscript writing
• Clinical research practice
• Study
• Scientific meeting
• Scientific article
• Research methodology
• conservative orthopedics

• UPMC Rooney Sports Complex, University of Pittsburgh, Pittsburgh, USA

  Volker Musahl

• Department of Orthopaedics, Sahlgrenska Academy, Gothenburg University, Sahlgrenska University Hospital, Gothenburg, Sweden

  Jón Karlsson

• Department of Orthopaedic Surgery and Traumatology, Kantonsspital Baselland (Bruderholz, Laufen und Liestal), Bruderholz, Switzerland

  Michael T. Hirschmann

• McMaster University, Hamilton, Canada

  Olufemi R. Ayeni

• Hospital for Special Surgery, New York, USA

  Robert G. Marx

• Department of Orthopaedic Surgery, NorthShore University HealthSystem, Evanston, USA

  Jason L. Koh

• Institute for Medical Science in Sports, Osaka Health Science University, Osaka, Japan

  Norimasa Nakamura

Volker Musahl, MD, is Associate Professor of Orthopaedic Surgery at the University of Pittsburgh School of Medicine, Associate Professor of Bioengineering at the University of Pittsburgh's Swanson School of Engineering, Program Director of the Sports Medicine fellowship program, and Medical Director of the UPMC Center for Sports Medicine. Dr. Musahl has received various honors and awards and in 2015 was appointed Assistant Editor-in-Chief of Knee Surgery, Sports Traumatology, Arthroscopy (KSSTA). His research interests include knee and shoulder biomechanics. 

Jon Karlsson, MD, PhD, is Professor of Orthopaedics and Sports Traumatology at Sahlgrenska Academy, Gothenburg University, Sweden, where he is a Senior Consultant and Academic Head of the Orthopaedic Department. He is the editor or author of more than 300 papers and 30 textbooks in Orthopaedics and Sports Traumatology. He has held important positions in both ESSKA and ISAKOS and is currently Editor-in-Chief of Knee Surgery, Sports Traumatology, Arthroscopy (KSSTA). 

Michael T. Hirschmann, MD, is Leading Consultant in Head and Knee Surgery, Department of Orthopaedic Surgery and Traumatology, Kantonsspital Baselland, Switzerland. He was awarded his Habilitation “venia docendi” from the University of Basel in 2012. Dr. Hirschmann is a member of the Executive Committee of the Gesellschaft für Arthroskopie und Gelenkchirurgie and Secretary General of European Knee Associates. He is a member of the editorial boards of various journals, including KSSTA and World Journal of Orthopedics. 

Olufemi R. Ayeni, MD, MSc, FRCSC, is Associate Professor in the Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. He is also Director of MacSports, Division of Orthopaedic Surgery, McMaster University. Dr. Ayeni is an ISAKOS Scientific Committee Member. He acts as a reviewer for a number of leading journals in Orthopaedics and Sports Medicine and is lead or co-author of over 150 peer-reviewed journal articles. 

Robert G. Marx, MS, MSc, is Attending Orthopaedic Surgeon at the Hospital for Special Surgery, Weill Cornell Medical College, New York, where he is Professor of Orthopaedic Surgery and Professor of Public Health. He is also Director of the Foster Center for Clinical Outcome Research, Hospital for Special Surgery. He is a former member of the Board of Directors of ISAKOS and has served as Chair of the ISAKOS Scientific Advisory Committee. Dr. Marx is the author of four books and 210 peer-reviewed articles. 

Jason Lee Koh, MD, MBA, is Chairman of the Department of Orthopaedic Surgery and Clinical Director of the Orthopaedic Institute at NorthShore University HealthSystem, Chicago. He is also Clinical Professor of Surgery at University of Chicago Pritzker School of Medicine. In 2012 he received the prestigious Charles Neer Award from the American Shoulder and Elbow Society. Dr. Koh has sat on numerous committees and is a member of the Board of Councilors of the American Academy of Orthopaedic Surgery. 

Norimasa Nakamura, MD, PhD, is an orthopaedic surgeon and Professor at the Institute for Medical Science in Sports, Osaka Health Science University, Osaka City, Japan. Dr. Nakamura is a Fellow of the Royal College of Surgeons (FRCS) (England). He is President of the International Cartilage Repair Society (ICRS) and a former chair of the Scientific Committee of ISAKOS. He is a member of the editorial boards of various leading journals in the field of Orthopaedics and author of more than 120 peer-reviewed papers.

Policies and ethics