Pathology and Biology of Human Germ Cell Tumors

1. Front Matter

   Pages i-xiv

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2. Germ Cell Tumors: Classifications, Definitions, and Terminology

   • Ivan Damjanov

   Pages 1-9

3. The Epidemiology of Malignant Germ Cell Tumors: The EUROCARE Study

   • Annalisa Trama, Franco Berrino

   Pages 11-21

4. Germ Cell Tumors from a Developmental Perspective: Cells of Origin, Pathogenesis, and Molecular Biology (Emerging Patterns)

   • J. Wolter Oosterhuis, Leendert H. J. Looijenga

   Pages 23-129

5. Diagnostic Immunopathology of Germ Cell Tumors

   • Ovidiu Preda, Francisco F. Nogales

   Pages 131-179

6. Management of Germ Cell Tumors

   • Manish Kohli, Ben Y. Zhang, Brian A. Costello

   Pages 181-194

7. Germ Cell Tumors of the Female Genital Tract

   • Francisco F. Nogales, Maolly Schuldt

   Pages 195-266

8. Testicular Germ Cell Tumors

   • Rafael E. Jimenez, Sounak Gupta, Loren P. Herrera-Hernandez, Thomas J. Sebo

   Pages 267-325

9. Mediastinal Germ Cell Tumors

   • Anja C. Roden

   Pages 327-364

10. Central Nervous System Germ Cell Tumors

    • M. Adelita Vizcaino, Fausto J. Rodriguez

    Pages 365-379

11. Pediatric Germ Cell Tumors

    • Eduardo Zambrano, Danielle Vargas De Stefano, Miguel Reyes-Múgica

    Pages 381-395

12. Germ Cell Tumors of Miscellaneous Extragonadal Sites

    • Alejandro Rubio-Fernández, Juan Antonio Retamero, Francisco F. Nogales

    Pages 397-417

13. Somatic-Type Malignancy in Germ Cell Tumors

    • Nooshin K. Dashti, Rafael E. Jimenez

    Pages 419-439

14. Back Matter

    Pages 441-449

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This book provides, for the first time, a detailed, up-to-date, holistic approach to the pathology and biology of germ cell tumors. The main focus is the complex histopathology of these tumors, but special considerations are also given to their morphologic variations in relation to age, gender and organ. Critical updates are provided on terminology and classification; the discussion of biology and pathogenesis includes references to many molecular genetic and immunohistochemical findings from recent stem cell research. Individual chapters are devoted to germ cell tumors at different anatomic locations, including not only the ovaries and testes but also the mediastinum and central nervous system, and pediatric tumors. All of the contributing authors are opinion leaders from universities of excellence in Europe and the United States. This monograph will be of wide interest to practitioners and researchers in many fields of medicine, including pathology, gynecology, urology, and pediatrics, as well as stem cell scientists.

• Germ cell tumor
• Differentiation
• Pluripotentiality
• Stem Cells
• Teratoma
• Mediastinum
• Seminoma
• Non seminoma
• Germ cell tumors
• Embryonal carcinoma
• Yolk sac tumor
• Choriocarcinoma
• Gonadal tumors
• Extra-gonadals germ cell tumors

• Departamento de Anatomía Patológica, Universidad de Granada Facultad de Medicina, Granada, Spain

  Francisco F. Nogales

• Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, USA

  Rafael E. Jimenez

Francisco F. Nogales has been professor of pathology at the University of Granada, Spain, since 1979 and President of the International of Gynecologic Pathologists (1992-94). His ample research in the field of Gynecologic Pathology has particularly focused on germ cell tumors. He has published over 150 papers and edited or contributed to more than 20 monographs, including WHO blue books. He holds several visiting and honorary professorships and doctorates from Universities in Europe and the Americas and is active as a board member of international Pathology journals.

Rafael E. Jimenez is genitourinary pathologist and an Associate Professor at Mayo Clinic, in Rochester, Minnesota, USA.   He has previously worked as surgical pathologist at Ohio State University. His research interest is primarily in kidney, bladder, prostate and testicular pathology. He has published over 55 papers and completed work on 10 books. He serves as  Associate editor.  BMC Cancer, Surgical Oncology and Imaging sub-section.

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