Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement

1. Front Matter

   Pages i-xvi

   PDF

2. Role of Nanotechnology in Skin Delivery of Drugs

   • Mehtab J. Abla, Neha D. Singh, Ajay K. Banga

   Pages 1-13

3. Liposomes as Drug Delivery Systems in Dermal and Transdermal Drug Delivery

   • Slavica Siler-Marinkovic

   Pages 15-38

4. Deformable (Transfersome®) Vesicles for Improved Drug Delivery into and Through the Skin

   • Gregor Cevc, Amla Chopra

   Pages 39-59

5. Ethosomes: Enhanced Delivery of Drugs to and Across the Skin

   • Denize Ainbinder, Biana Godin, Elka Touitou

   Pages 61-75

6. Invasomes: Vesicles for Enhanced Skin Delivery of Drugs

   • Nina Dragicevic, Daya Dass Verma, Alfred Fahr

   Pages 77-92

7. Penetration Enhancer-Containing Vesicles for Cutaneous Drug Delivery

   • Maria Manconi, Chiara Sinico, Anna Maria Fadda

   Pages 93-110

8. Stratum Corneum Lipid Liposomes: Drug Delivery Systems and Skin Models

   • Gamal M. El Maghraby

   Pages 111-119

9. Surface-Charged Vesicles for Penetration Enhancement

   • María Luisa González-Rodríguez, María José Cózar-Bernal, Adamo Fini, Antonio María Rabasco

   Pages 121-136

10. Ultradeformable Vesicles as Skin Drug Delivery Systems: Mechanisms of Action

    • Gamal M. El Maghraby

    Pages 137-145

11. Niosomes and Proniosomes for Enhanced Skin Delivery

    • Rita Muzzalupo

    Pages 147-160

12. Nanostructured Lipid Carriers (NLC): The Second Generation of Solid Lipid Nanoparticles

    • Rainer H. Müller, Ulrike Alexiev, Pricillia Sinambela, Cornelia M. Keck

    Pages 161-185

13. Polymeric Nano (and Micro) Particles as Carriers for Enhanced Skin Penetration

    • Mona M. A. Abdel-Mottaleb, Alf Lamprecht

    Pages 187-199

14. Polymeric Nanocapsules for Topical Delivery

    • Adriana R. Pohlmann, Cassia B. Detoni, Karina Paese, Karine Coradini, Ruy C. R. Beck, Sílvia S. Guterres

    Pages 201-221

15. Polymeric Micelles in Dermal and Transdermal Delivery

    • Maria Lapteva, Michael Möller, Yogeshvar N. Kalia

    Pages 223-240

16. Core-Shell Nanotransporters for the Skin

    • Monika Schäfer-Korting, Eder Lilia Romero

    Pages 241-251

17. Microemulsions

    • Sari Pappinen, Arto Urtti

    Pages 253-262

18. Percutaneous Penetration Enhancement Potential of Microemulsion-Based Organogels

    • Ljiljana Djekic, Marija Primorac

    Pages 263-282

19. Nanocrystals for Passive Dermal Penetration Enhancement

    • Rainer H. Müller, Xuezhen Zhai, Gregori B. Romero, Cornelia M. Keck

    Pages 283-295

20. Vesicles for Transdermal Delivery of Peptides and Proteins

    • Heather A. E. Benson

    Pages 297-307

Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered and the latest findings are provided on skin structure and function, mathematics in skin permeation and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners and also students.​

• Lipid-based/ surfactant-based vesicles
• Nanocrystals
• Polymer-based nano/micro particles
• Skin delivery
• Skin permeation

“The purpose is to provide the most current information on drug delivery via percutaneous routes. Researchers and chemists in the drug industry who are designing medications, moisturizers, or sunscreens for percutaneous delivery are the target audience. … You will want to read this book if you are pursuing a cure or have found a cure and need to create an effective, noninvasive delivery system.” (Patricia Wong, Doody's Book Reviews, June, 2016)

• Department of Manufacturing, Apoteka "Beograd", Belgrade, Serbia

  Nina Dragicevic

• San Francisco, USA

  Howard I. Maibach

Howard I. Maibach is Professor of Dermatology at the University of California, San Francisco. He is a leading authority in the fields of dermatotoxicology and dermatopharmacology, in which he has conducted much original research and written very extensively, with a total of more than 2,500 publications as lead or co-author. Professor Maibach has served on the editorial boards of more than 30 scientific journals and is a member of many professional societies, including the American Academy of Dermatology and the International Commission on Occupational Health. He has also been the recipient of numerous honors, both within the United States and overseas. Nina Dragićević-Ćurić graduated from the University of Belgrade, Faculty of Pharmacy in 1999 and subsequently obtained an MSc and a PhD (summa cum laude, Dr. rer. nat.) in Pharmaceutical Technology from the University of Belgrade and the Friedrich-Schiller University, Jena, respectively. Dr. Dragićević-Ćurić is an accredited Specialist in Pharmaceutical Technology. Since 2007 she has been responsible for the preparation of compounded drugs in pharmacies of the state pharmaceutical company “Apoteka Beograd” in Belgrade. She has published in a variety of international journals.

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