Overview
Provides a comprehensive critique of models of percutaneous absorption, their source data and both their limitations and correct use
Enriches readers’ understanding of the implications of various models
Shows how to tailor models to particular circumstances and accurately interpret the results
Will be of interest to researchers in academic and industry working in the fields of pharmaceuticals, occupational exposure, risk assessment and cosmetics
Includes supplementary material: sn.pub/extras
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Table of contents (10 chapters)
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Front Matter
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Back Matter
Keywords
About this book
This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models.
The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics.
Authors and Affiliations
Bibliographic Information
Book Title: Predictive Methods in Percutaneous Absorption
Authors: Gary P. Moss, Darren R. Gullick, Simon C. Wilkinson
DOI: https://doi.org/10.1007/978-3-662-47371-9
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2015
Hardcover ISBN: 978-3-662-47370-2Published: 10 July 2015
Softcover ISBN: 978-3-662-50831-2Published: 17 October 2016
eBook ISBN: 978-3-662-47371-9Published: 01 July 2015
Edition Number: 1
Number of Pages: XV, 199
Number of Illustrations: 8 b/w illustrations, 8 illustrations in colour
Topics: Pharmacology/Toxicology, Human Physiology, Dermatology, Physiological, Cellular and Medical Topics