Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement

1. Front Matter

   Pages i-xvi

   PDF

2. Hyaluronic Acid for Percutaneous Drug Delivery

   • Sarah Hedtrich, Wolfgang Frieß

   Pages 1-10

3. Chemical Penetration Enhancers: Classification and Mode of Action

   • Nina Dragicevic, Jelena Predic Atkinson, Howard I. Maibach

   Pages 11-27

4. Penetration Enhancers and Their Mechanism Studied on a Molecular Level

   • Annett Schroeter, Adina Eichner, Josefin Mueller, Reinhard H. H. Neubert

   Pages 29-37

5. Structure-Activity Relationship of Chemical Penetration Enhancers

   • Narayan Kanikkannan, R. Jayachandra Babu

   Pages 39-54

6. Quantitative Structure–Enhancement Relationship and the Microenvironment of the Enhancer Site of Action

   • S. Kevin Li, William I. Higuchi

   Pages 55-67

7. Azone® and Its Analogues as Penetration Enhancers

   • Josef Jampílek

   Pages 69-105

8. Aromatic Iminosulfuranes, A Novel Class of Transdermal Penetration Enhancers

   • Tannaz Ramezanli, Pei-Chin Tsai, Mania Dorrani, Bozena B. Michniak-Kohn

   Pages 107-114

9. Alaptide as Transdermal Permeation Modifier

   • Josef Jampílek, Jiří Dohnal

   Pages 115-132

10. Fatty Alcohols, Fatty Acids, and Fatty Acid Esters as Penetration Enhancers

    • R. Jayachandra Babu, Li Chen, Narayan Kanikkannan

    Pages 133-150

11. Ethanol and Other Alcohols: Old Enhancers, Alternative Perspectives

    • Charles M. Heard

    Pages 151-172

12. Terpenes and Essential Oils as Skin Penetration Enhancers

    • Jayamanti Pandit, Mohammed Aqil, Yasmin Sultana

    Pages 173-193

13. Transcutol® (Diethylene Glycol Monoethyl Ether): A Potential Penetration Enhancer

    • Yousef Javadzadeh, Khosro Adibkia, Hamed Hamishekar

    Pages 195-205

14. Surfactants as Penetration Enhancers for Dermal and Transdermal Drug Delivery

    • Taravat Ghafourian, Ali Nokhodchi, Waseem Kaialy

    Pages 207-230

15. Natural Emulsifiers of the Alkyl Polyglucoside Type and Their Influence on the Permeation of Drugs

    • Ivana Pantelic, Jela Milic, Gordana Vuleta, Nina Dragicevic, Snezana Savic

    Pages 231-250

16. Nonionic Surfactants: Polyethylene Glycol (PEG) Ethers and Fatty Acid Esters as Penetration Enhancers

    • Antonella Casiraghi, Francesca Selmin, Paola Minghetti, Francesco Cilurzo, Luisa Montanari

    Pages 251-271

17. Sucrose Esters as Transdermal Permeation Enhancers

    • María Guadalupe Nava-Arzaluz, Elizabeth Piñón-Segundo, Adriana Ganem-Rondero

    Pages 273-290

18. Pyrrolidones as Penetration Enhancers

    • R. Jayachandra Babu, Li Chen

    Pages 291-299

19. Urea and Derivatives as Penetration Enhancers

    • Adrian C. Williams

    Pages 301-308

20. Transkarbams: Transdermal Penetration-Enhancing Carbamates

    • Alexandr Hrabálek, Kateřina Vávrová

    Pages 309-323

Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered and the latest findings are provided on skin structure and function, mathematics in skin permeation and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners and also students.

• Cutaneous vaccination
• Nanoparticles
• Skin hydration
• Transdermal delivery
• Vesicles

• Department of Manufacturing, Apoteka "Beograd", Belgrade, Serbia

  Nina Dragicevic

• Dermatology Clinic, University of California San Francisco Dermatology Clinic, San Francisco, USA

  Howard I. Maibach

Howard I. Maibach is Professor of Dermatology at the University of California, San Francisco. He is a leading authority in the fields of dermatotoxicology and dermatopharmacology, in which he has conducted much original research and written very extensively, with a total of more than 2,500 publications as lead or co-author. Professor Maibach has served on the editorial boards of more than 30 scientific journals and is a member of many professional societies, including the American Academy of Dermatology and the International Commission on Occupational Health. He has also been the recipient of numerous honors, both within the United States and overseas. Nina Dragićević-Ćurić graduated from the University of Belgrade, Faculty of Pharmacy in 1999 and subsequently obtained an MSc and a PhD (summa cum laude, Dr. rer. nat.) in Pharmaceutical Technology from the University of Belgrade and the Friedrich-Schiller University, Jena, respectively. Dr. Dragićević-Ćurić is an accredited Specialist in Pharmaceutical Technology. Since 2007 she has been responsible for the preparation of compounded drugs in pharmacies of the state pharmaceutical company “Apoteka Beograd” in Belgrade. She has published in a variety of international journals.

Policies and ethics