Skip to main content
SpringerLink
Log in
Book cover

Principles of Safety Pharmacology

  • Book
  • © 2015

Overview

Editors:
  1. Michael K. Pugsley

    1. Drug Safety Sciences, Johnson & Johnson PR&D, Raritan, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Michael J Curtis

    1. Cardiovascular Division, Faculty of Life Sciences & Medicine, St Thomas' Hospital, King's College London, Rayne Institute, London, United Kingdom

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • First resource book in either Pharmacology or Medicine that describes the regulatory and pharmacology outlined in this book
  • All safety pharmacology areas outlined are accompanied by comprehensive background information, detailed figures, inclusive tables and an up-to-date list of the most important references for the area discussed
  • Introducing topics in an easily understandable format for researchers in many varying disciplines

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 229)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (17 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. An Overview of Safety Pharmacology and Its Role in Drug Discovery

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. A Historical View and Vision into the Future of the Field of Safety Pharmacology

      • Alan S. Bass, Toshiyasu Hombo, Chieko Kasai, Lewis B. Kinter, Jean-Pierre Valentin
      Pages 3-45

    3. In Vitro Early Safety Pharmacology Screening: Perspectives Related to Cardiovascular Safety

      • Gary Gintant
      Pages 47-64

    4. Safety Pharmacology in Drug Discovery and Development

      • Bruce H. Morimoto, Erin Castelloe, Anthony W. Fox
      Pages 65-80

  3. The Safety Pharmacology Core Battery

    1. Front Matter

      Pages 81-81
      Download chapter PDF

    2. CNS Adverse Effects: From Functional Observation Battery/Irwin Tests to Electrophysiology

      • Carlos Fonck, Alison Easter, Mark R. Pietras, Russell A. Bialecki
      Pages 83-113

    3. Preclinical Abuse Potential Assessment

      • Mary Jeanne Kallman
      Pages 115-130

    4. Overview of Respiratory Studies to Support ICH S7A

      • Michael Stonerook
      Pages 131-148

    5. Biophysics and Molecular Biology of Cardiac Ion Channels for the Safety Pharmacologist

      • Michael K. Pugsley, Michael J. Curtis, Eric S. Hayes
      Pages 149-203

    6. Sensitivity and Specificity of the In Vitro Guinea Pig Papillary Muscle Action Potential Duration for the Assessment of Drug-Induced Torsades De Pointes Liability in Humans

      • Joffrey Ducroq
      Pages 205-219

    7. Haemodynamic Assessment in Safety Pharmacology

      • Simon Authier, Michael K. Pugsley, Michael J. Curtis
      Pages 221-241

    8. High Definition Oscillometry: Non-invasive Blood Pressure Measurement and Pulse Wave Analysis

      • Beate Egner
      Pages 243-264

  4. Supplemental Safety Pharmacology

    1. Front Matter

      Pages 265-265
      Download chapter PDF

    2. The Safety Pharmacology of Auditory Function

      • Matthew M. Abernathy
      Pages 267-290

    3. Gastrointestinal Safety Pharmacology in Drug Discovery and Development

      • Ahmad Al-Saffar, André Nogueira da Costa, Annie Delaunois, Derek J. Leishman, Louise Marks, Marie-Luce Rosseels et al.
      Pages 291-321

    4. Renal Safety Pharmacology in Drug Discovery and Development

      • Amanda Benjamin, Andre Nogueira da Costa, Annie Delaunois, Marie-Luce Rosseels, Jean-Pierre Valentin
      Pages 323-352

    5. Inclusion of Safety Pharmacology Endpoints in Repeat-Dose Toxicity Studies

      • Will S. Redfern
      Pages 353-381

  5. Safety Pharmacology of Biological and Anticancer Pharmaceuticals

    1. Front Matter

      Pages 383-383
      Download chapter PDF

    2. Safety Pharmacology Evaluation of Biopharmaceuticals

      • Hamid R. Amouzadeh, Michael J. Engwall, Hugo M. Vargas
      Pages 385-404
Back to top

Keywords

About this book

This book illustrates, in a comprehensive manner, the most current areas of importance to Safety Pharmacology, a burgeoning unique pharmacological discipline with important ties to academia, industry and regulatory authorities. It provides readers with a definitive collection of topics containing essential information on the latest industry guidelines and overviews current and breakthrough topics in both functional and molecular pharmacology. An additional novelty of the book is that it constitutes academic, pharmaceutical and biotechnology perspectives for Safety Pharmacology issues. Each chapter is written by an expert in the area and includes not only a fundamental background regarding the topic but also detailed descriptions of currently accepted, validated models and methods as well as innovative methodologies used in drug discovery.

Editors and Affiliations

  • Drug Safety Sciences, Johnson & Johnson PR&D, Raritan, USA

    Michael K. Pugsley

  • Cardiovascular Division, Faculty of Life Sciences & Medicine, St Thomas' Hospital, King's College London, Rayne Institute, London, United Kingdom

    Michael J Curtis

Bibliographic Information

  • Book Title: Principles of Safety Pharmacology

  • Editors: Michael K. Pugsley, Michael J Curtis

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-662-46943-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2015

  • Hardcover ISBN: 978-3-662-46942-2Published: 30 June 2015

  • Softcover ISBN: 978-3-662-52096-3Published: 29 October 2016

  • eBook ISBN: 978-3-662-46943-9Published: 19 June 2015

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: VIII, 481

  • Number of Illustrations: 24 b/w illustrations, 39 illustrations in colour

  • Topics: Pharmaceutical Sciences/Technology

Publish with us

Policies and ethics

Back to top

Search

Navigation