Skip to main content
  • Book
  • © 2015

Vaccine Analysis: Strategies, Principles, and Control

  • Equips readers to handle the complex analysis of vaccines

  • Treats both research and application aspects

  • Describes analytical and quality control technologies

  • Includes supplementary material: sn.pub/extras

Buy it now

Buying options

eBook USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

This is a preview of subscription content, log in via an institution to check for access.

Table of contents (17 chapters)

  1. Front Matter

    Pages i-xii
  2. Live Attenuated Viral Vaccines

    • Mark S. Galinski, Kuldip Sra, John I. Haynes II, Jennifer Naspinski
    Pages 1-44
  3. Inactivated Viral Vaccines

    • Barbara Sanders, Martin Koldijk, Hanneke Schuitemaker
    Pages 45-80
  4. Recombinant Virus-like Particle Protein Vaccines

    • Robert D. Sitrin, Qinjian Zhao, Clinton S. Potter, Bridget Carragher, Michael W. Washabaugh
    Pages 81-112
  5. Analysis of Influenza Vaccines

    • Pierre-Alain Moisset, Jeffrey Pederson, Nathalie Landry
    Pages 113-137
  6. Live-Attenuated and Inactivated Whole-Cell Bacterial Vaccines

    • Anita H. J. van den Biggelaar, Jan T. Poolman
    Pages 139-186
  7. Analytical Control Strategy of Bacterial Subunit Vaccines

    • Shwu-Maan Lee, Vincent Turula, Bradford Powell, Mikkel Nissum, Mariagrazia Pizza, Claudia Magagnoli et al.
    Pages 187-270
  8. Bacterial Polysaccharide Vaccines: Analytical Perspectives

    • Earl Zablackis, Philippe Talaga, Suddham Singh
    Pages 271-299
  9. Glycoconjugate Vaccines

    • Neil Ravenscroft, Paolo Costantino, Philippe Talaga, Roberto Rodriguez, William Egan
    Pages 301-381
  10. Role of Analytics in Viral Safety

    • Rebecca L. Sheets, Paul A. Duncan
    Pages 397-443
  11. Deep Sequencing Applications for Vaccine Development and Safety

    • David Onions, Colette Côté, Brad Love, John Kolman
    Pages 445-477
  12. Quality-by-Design: As Related to Analytical Concepts, Control and Qualification

    • Beth Junker, Earl Zablackis, Thorsten Verch, Tim Schofield, Pierre Douette
    Pages 479-520
  13. Vaccine Potency Assays

    • Todd Ranheim, Ned Mozier, William Egan
    Pages 521-541
  14. Establishing a Shelf Life and Setting Lot-Release Specifications

    • William Egan, Timothy Schofield
    Pages 543-562
  15. Vaccine Reference Standards

    • Brian K. Nunnally
    Pages 563-572
  16. Lot Release of Vaccines by Regulatory Authorities and Harmonization of Testing Requirements

    • Rajesh K. Gupta, Chander K. Gupta, Laurent Mallet
    Pages 573-596
  17. Dendritic Cell Targeting Vaccines

    • Yoonkyung Do, Bradford Powell
    Pages 597-659
  18. Back Matter

    Pages 661-665

About this book

This book is an indispensable tool for anyone involved in the research, development, or manufacture of new or existing vaccines. It describes a wide array of analytical and quality control technologies for the diverse vaccine modalities.

Topics covered include the application of both classical and modern bio-analytical tools; procedures to assure safety and control of cross contamination; consistent biological transition of vaccines from the research laboratory to manufacturing scale; whole infectious attenuated organisms, such as live-attenuated and inactivated whole-cell bacterial vaccines and antiviral vaccines using attenuated or inactivated viruses; principles of viral inactivation and the application of these principles to vaccine development; recombinant DNA approaches to produce modern prophylactic vaccines; bacterial subunit, polysaccharide and glycoconjugate vaccines; combination vaccines that contain multiple antigens as well as regulatory requirements and the hurdles of licensure.

Editors and Affiliations

  • Apex, USA

    Brian K. Nunnally

  • Pfizer BioTherapeutics Pharmaceutical Sc, Pearl River, USA

    Vincent E. Turula

  • Sitrin Solutions, Lafayette Hill, USA

    Robert D. Sitrin

Bibliographic Information

  • Book Title: Vaccine Analysis: Strategies, Principles, and Control

  • Editors: Brian K. Nunnally, Vincent E. Turula, Robert D. Sitrin

  • DOI: https://doi.org/10.1007/978-3-662-45024-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2015

  • Hardcover ISBN: 978-3-662-45023-9Published: 09 December 2014

  • Softcover ISBN: 978-3-662-52266-0Published: 10 September 2016

  • eBook ISBN: 978-3-662-45024-6Published: 27 November 2014

  • Edition Number: 1

  • Number of Pages: XII, 665

  • Number of Illustrations: 48 b/w illustrations, 76 illustrations in colour

  • Topics: Vaccine, Immunology, Medical Biochemistry

Buy it now

Buying options

eBook USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access