Cancer Immunology

1. Front Matter

   Pages i-xlvii

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2. Introduction on Cancer Immunology and Immunotherapy

   • Nima Rezaei, Seyed Hossein Aalaei-Andabili, Howard L. Kaufman

   Pages 1-8

3. Inflammatory and Innate Immune Cells in Cancer Microenvironment and Progression

   • Patrick Brennecke, Paola Allavena, Ilaria Laface, Alberto Mantovani, Barbara Bottazzi

   Pages 9-28

4. Role of Innate Immunity in Cancers and Antitumor Response

   • Masahisa Jinushi, Muhammad Baghdadi

   Pages 29-46

5. B Cells in Cancer Immunology: For or Against Cancer Growth?

   • Qiao Li, Qin Pan, Huimin Tao, Xiao-Lian Zhang, Shiang Huang, Alfred E. Chang

   Pages 47-60

6. The Role of Exhaustion in Tumor-Induced T Cell Dysfunction in Cancer

   • Heriberto Prado-Garcia, Susana Romero-Garcia, Jose Sullivan Lopez-Gonzalez

   Pages 61-75

7. Regulatory T Cells and Th17 Cells in Cancer Microenvironment

   • Chang H. Kim

   Pages 77-91

8. Role of Cytokines in Tumor Immunity and Immune Tolerance to Cancer

   • Murugaiyan Gopal

   Pages 93-119

9. Role of Chemokines and Chemokine Receptors in Cancer

   • Mathieu Paul Rodero, Christophe Combadière, Alexandre Boissonnas

   Pages 121-142

10. The CD95/CD95L Signaling Pathway: A Role in Carcinogenesis

    • Amélie Fouqué, Patrick Legembre

    Pages 143-160

11. MHC Class I Molecules and Cancer Progression: Lessons Learned from Preclinical Mouse Models

    • Irene Romero, Ignacio Algarra, Angel M. Garcia-Lora

    Pages 161-175

12. Role of Plasmacytoid Dendritic Cells in Cancer

    • Michela Terlizzi, Aldo Pinto, Rosalinda Sorrentino

    Pages 177-194

13. Cancer Immunoediting: Immunosurveillance, Immune Equilibrium, and Immune Escape

    • Alka Bhatia, Yashwant Kumar

    Pages 195-208

14. Apoptosis and Cancer

    • Mei Lan Tan, Heng Kean Tan, Tengku Sifzizul Tengku Muhammad

    Pages 209-242

15. Autophagy and Necroptosis in Cancer

    • Mei Lan Tan, Heng Kean Tan, Ahmed Ismail Hassan Moad, Tengku Sifzizul Tengku Muhammad

    Pages 243-273

16. Prognostic Value of Innate and Adaptive Immunity in Cancers

    • Fabio Grizzi, Giuseppe Di Caro, Federica Marchesi, Luigi Laghi

    Pages 275-284

17. Epigenetics and microRNAs in Cancer

    • Petra M. Wise, Kishore B. Challagundla, Muller Fabbri

    Pages 285-294

18. Immunogenetics of Cancer

    • Armin Hirbod-Mobarakeh, Ali Akbar Amirzargar, Behrouz Nikbin, Mohammad Hossein Nicknam, Anton Kutikhin, Nima Rezaei

    Pages 295-341

19. Primary Immunodeficiencies and Cancers

    • Mona Hedayat, Waleed Al-Herz, Asghar Aghamohammadi, Kim E. Nichols, Nima Rezaei

    Pages 343-375

20. Immunosenescence, Oxidative Stress, and Cancers

    • Tamas Fulop, Graham Pawelec, Gilles Dupuis, Rami Kotb, Bertrand Friguet, Anis Larbi

    Pages 377-393

Cancer Immunology is intended as an up-to-date, clinically relevant review of cancer immunology and immunotherapy. This volume is focused on immunopathology of cancers. The interactions between cancerous cells and various components of the innate and adaptive immune system are fully described. The principal focus, however, is very much on clinical aspects, the aim being to educate clinicians in the clinical implications of the most recent research and new developments in the field. Over the past decade, understanding of the interactions between the immune system and cancerous cells has increased markedly, leading to the development of combinatorial immunotherapeutic strategies to combat cancer. This translational, clinically oriented book will be of special value to clinical immunologists, hematologists and oncologists.  

• Cancer Immunotherapy
• Cancer immunology
• Translational Medicine

“This book will provide up to date information about various aspects of tumor immunology. It will be useful to both clinical and experimental oncologists. Accordingly this book should be available through libraries in printed or on-line version for all in need for excellently collected survey of information about tumor immunology.” (Katarina Polakova, Neoplasma, Issue 3, 2015)

• Children's Medical Center Hospital, Tehran University of Medical Sciences Research Center for Immunodeficiencies, Tehran, Iran

  Nima Rezaei

Nima Rezaei gained his medical degree from Tehran University of Medical Sciences and Health Services in 2002 and subsequently obtained MSc in Molecular and Genetic Medicine and PhD in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also spent a short-term fellowship of Clinical Immunology and Bone Marrow Transplantation in the Newcastle General Hospital. Since 2010, Dr. Rezaei has worked at the Department of Immunology, School of Medicine, Tehran University of Medical Sciences; he is also the Chief Executive Director of the Children’s Medical Center Hospital, Tehran and a co-founder and Deputy President of the Research Center for Immunodeficiencies. In addition, Dr. Rezaei is an Honorary Research Fellow at the Department of Infection and Immunity, School of Medicine and Biomedical Sciences, University of Sheffield. Dr. Rezaei has already been the Director of more than 50 research projects and has designed and participated in several international collaborative projects. Dr. Rezaei is an editorial assistant or board member for more than 20 international journals. He has published more than 400 articles in international scientific journals and edited ten further books.

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