Infections in Hematology

1. Front Matter

   Pages i-viii

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2. Epidemiology: Infections in Patients with Hematologic Malignancies

   1. Front Matter

      Pages 1-1

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   2. Infections in Patients with Acute Leukemia

      • Kenneth V. I. Rolston

      Pages 3-23

   3. Infections in Patients with Malignant Lymphomas

      • Kenneth V. I. Rolston

      Pages 25-37

   4. Consequences from Specific Treatment Modalities

      • Georg Maschmeyer

      Pages 39-47

   5. Infections After High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation

      • Marcio Nucci, Elias Anaissie

      Pages 49-61

   6. Microbiological Background

      • Murat Akova

      Pages 63-87

3. Diagnosis

   1. Front Matter

      Pages 89-89

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   2. The Diagnostic Approach to the Febrile Neutropenic Patient: Clinical Considerations

      • Eric J. Bow

      Pages 91-111

   3. Diagnostic Radiology in Hematological Patients with Febrile Neutropenia

      • Claus Peter Heussel

      Pages 113-135

   4. Risk Stratification in Febrile Neutropenic Patients

      • Marianne Paesmans

      Pages 137-152

4. Therapeutic Strategies

   1. Front Matter

      Pages 153-153

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   2. Fever of Unknown Origin: Treatment According to Risk Assessment

      • Georg Maschmeyer

      Pages 155-163

   3. Pulmonary Complications

      • Georg Maschmeyer

      Pages 165-185

   4. Vascular Catheter-Related Infections

      • Luma Dababneh, William Shomali, Issam I. Raad

      Pages 187-195

   5. Gastrointestinal Complications

      • Nicole M. A. Blijlevens

      Pages 197-210

   6. Central Nervous System Infections

      • Martin Schmidt-Hieber

      Pages 211-226

5. Antimicrobial Treatment (Including Important Pitfalls, Toxicities and Interactions)

   1. Front Matter

      Pages 227-227

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   2. Antibacterial Agents

      • Winfried V. Kern

      Pages 229-258

   3. Antifungal Agents

      • George R. Thompson III, Thomas F. Patterson

      Pages 259-272

Infections are among the most frequent complications in patients with hematological malignancies and in those undergoing high-dose chemotherapy and autologous hematopoietic stem cell transplantation. A profound knowledge on the epidemiology, diagnostic approaches, treatment modalities and prophylactic strategies is essential for the clinical management of these complications in patients who are often severely immunocompromised owing to their underlying diseases and in particular, the intensive myelosuppressive chemo and immunotherapy. This textbook provides a clinically oriented, compact and up-to-date overview on infections in hematology patients and their management. The typical pathogens to be considered in different subgroups of patients are identified and further aspects of the microbiological background are explored. Clinical, imaging, and laboratory-based diagnostic techniques are discussed and therapeutic strategies appropriate to different situations are then presented, with due attention to the pitfalls, toxicities and interactions that can arise during antimicrobial treatment. Strategies to prevent infection are also outlined, encompassing antimicrobial prophylaxis, isolation procedures, hospital hygiene, protective immunization and the use of hematopoietic growth factors.

• Diagnosis
• Infection
• Leukemia
• Neutropenia
• Stem Cell Transplantation

“This is a comprehensive review of the risk factors, microbiology, prophylaxis, and management of infections in patients with hematological malignancies. … The audience includes students, residents, and practitioners who care for patients with hematological malignancies, and the book targets this group well. … Physicians who care for patients with hematological malignancies need a book like this to give them a comprehensive overview of the support and management of infections in these patients.” (Joseph C. Alvarnas, Doody's Book Reviews, May, 2015)

• Department of Hematology, Oncology and Palliative Care, Klinikum Ernst von Bergmann, Potsdam, Germany

  Georg Maschmeyer

• Department of Infectious Diseases, Infection Control and Employee Health, M.D. Anderson Cancer Center University of Texas, Houston, USA

  Kenneth V.I. Rolston

Policies and ethics