The Immune Functions of Epidermal Langerhans Cells

1. Front Matter

   Pages i-xv

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2. Introduction: Cutaneous Dendritic Cells: Distinctive Antigen-Presenting Cells for Experimental Models and Disease States

   • Ralph M. Steinman, Kayo Inaba, Gerold Schuler

   Pages 1-19

3. Human Langerhans Cells Derived from CD34+ Blood Precursors: Mode of Generation, Phenotypic and Functional Analysis, and Experimental and Clinical Applicability

   • Dirk Strunk, Georg Stingl

   Pages 21-36

4. Cytokine Receptors on Epidermal Langerhans Cells

   • Eckhart Kämpgen, Nikolaus Romani, Franz Koch, Andreas Eggert, Gerold Schuler

   Pages 37-56

5. The Role of Interleukin-1β and Interleukin-10 in Langerhans Cell-Mediated Immune Responses

   • Alexander H. Enk, Stephen I. Katz

   Pages 57-72

6. Immunoelectron Microscopic Analysis of Major Histocompatibility Class II Expression on Human Epidermal Langerhans Cells

   • A. Mieke Mommaas, Frits Koning

   Pages 73-85

7. Antigen Presentation by Langerhans/Dendritic Cells

   • Ursula Neiß, Karin Demleitner, Alexandra Marx, Maria Mehlig, Christoph Scheicher, Konrad Reske

   Pages 87-101

8. Langerhans Cell Migration: Initiation and Regulation

   • Ian Kimber, Marie Cumberbatch

   Pages 103-117

9. Ultraviolet Radiation-Mediated Defects in Langerhans Cell Function

   • Paul R. Bergstresser, Akira Takashima

   Pages 119-140

10. Presentation of Tumor Antigens by Langerhans Cells and Other Dendritic Cells

    • Stephan Grabbe, Richard D. Granstein

    Pages 141-157

11. Langerhans Cells in Cutaneous Leishmaniasis

    • Heidrun Moll, Stefanie Flohé, Christine Blank

    Pages 159-175

12. Langerhans Cells and HIV Infection

    • Colette Dezutter-Dambuyant, Anne-Sophie Charbonnier, Marie-Madeleine Fiers, Pascale Delorme, Nathalie Dusserre, Catherine Tsagarakis et al.

    Pages 177-190

13. Back Matter

    Pages 191-197

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This book is about the phenotypic and functional features of epidermal Langerhans cells in experimental models and in clinical medicine. Langerhans cells, members of the dendritic cell system in the skin, are critically involved in the regulation of cell-mediated immune responses and gain increasing attention in a wide spectrum of clinical areas such as allergy, autoimmunity, transplantation and resistance to tumors and infections. The book covers the latest, most timely developments in this rapidly advancing field. Leading researchers describe functional analyses at the cell and molecular level, elucidating processes related to antigen presentation and the role of cytokines, and discuss perspectives for a future use of Langerhans cells and other dendritic cells in the immunotherapy of various diseases.

• antigen
• antigen presentation
• autoimmunity
• cytokine
• diseases
• immune response
• immunity
• immunotherapy
• infection
• infections
• resistance
• transplantation

• Research Center for Infectious Diseases, University of Würzburg, Würzburg, Germany

  Heidrun Moll

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