The Human T-Cell Receptor Repertoire and Transplantation

1. Front Matter

   Pages i-xi

   PDF

2. General Introduction

   • Peter J. van den Elsen

   Pages 1-28

3. The Circulating Human Peripheral T-Cell Repertoire

   • Linda Struyk, Gail E. Hawes, Frank Raaphorst, Marja van Eggermond, Barbara Godthelp, Peter J. van den Elsen

   Pages 29-61

4. T Cell Receptor Usage in Alloreactivity

   • Gail E. Hawes, Peter J. van den Elsen

   Pages 63-84

5. T-Cell Receptor Usage Among Graft Infiltrating T Lymphocytes

   • James T. Kurnick, Makiko Kumagai-Braesch, Carol P. Leary, Richard Waitkus, Lenora A. Boyle, Peter J. van den Elsen et al.

   Pages 85-100

6. T-Cell Receptor V-Gene Usage in T-Cell Lines Propogated from Graft-Infiltrating T Lymphocytes in Needle Biopsies of Rejecting Renal Allografts

   • Benito A. Yard, Thomas Reterink, Peter J. van den Elsen, M. E. Paape, Jan Antony Bruijn, Leendert A. van Es et al.

   Pages 101-115

7. Structure of T Cell Receptor Vα and Vβ Chains Expressed by T-Lymphocytes in Cardiac Allograft Derived Cell Lines

   • Gert Datema, Len Vaessen, Rene Daane, Carla Baan, Willem Weimar, Frans Claas et al.

   Pages 117-147

8. Involvement of Minor Histocompatability Antigens in the Rejection of an HLA Identical Renal Transplant from a Living Related Donor

   • Benito A. Yard, Thomas Reterink, Jan Antony Bruijn, Peter J. van den Eisen, Frans J. Claas, Mohamed R. Daha et al.

   Pages 149-162

9. Concluding Remarks

   • Peter J. van den Eisen

   Pages 163-167

10. Back Matter

    Pages 169-173

    PDF

these analyses it became clear that the MHC class I molecule com­ prised a distinct groove on the external side of the molecule. The sides of the groove are formed by the a-helical structures of the a and a 1 2 domains and a floor which is formed by 8 anti-parallel 13 strands. The various polymorphic residues, as determined from DNA sequence analysis, are localized within these a-helices and 13-plated sheets within the groove. More importantly, these analyses also revealed the presence of elec­ tron-dense material in the groove. This material was subsequently iden­ 568 10 tified as a linear peptide of 8-10 amino acids long. • •- High resolu­ tion crystallographic analyses of the class I MHC structure have revealed the existence of so-called pockets within the grooves of the MHC class I molecules. These pockets designated A-F, exhibited allele-specificity and are directly involved in the binding of the peptide, primarily through interaction with the dominant anchor residues as found in MHC class I associated pep tides. 6,7,9,11 The class II MHC antigens consist on the cell surface of a 34 kD a chain non-covalently associated with a 28 kD 13 chain. With the excep­ tion of the DR a-chain, all other MHC class II a and 13 chains are poly­ morphic.

• T cell
• T-lymphocytes
• antigen
• cell lines
• complementarity determining region 3
• cytotoxicity
• genes
• graft-infiltrating
• heart transplantation
• histocompatibility
• immunology
• lymphocytes
• major histocompatibility complex
• transplantation
• transplantation immunology

• Department of Immunohematology and Blood Bank, University Hospital Leiden, Leiden, The Netherlands

  Peter J. Elsen

Policies and ethics